The inhibitory effect of noradrenaline on thyrotrophin-stimulated 3,5,3′-tri-iodothyronine and thyroxine release is mediated through a Ca2+-dependent process in the thyroid gland of the mouse

Oda, Yasuo; Mashita, Kazuhiko; Mori-Tanaka, M.; Kitajima, Koichi; Miyagawa, Jun‐ichiro; Tajima, Koji; Hanafusa, T; Kôno, Norio; Matsuzawa, Yoko

doi:10.1677/joe.0.1380073

Cited by 2 publications

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References 21 publications

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“…Interactions of NE and OT in thyrocytes probably proceeding after cAMP formation [10] remain to be studied. These mechanisms are similar to the inhibitory effects of NE on thyrotropin-stimu!ated thyrocytes [9,11].…”

Section: Resultsmentioning

confidence: 56%

Norepinephrine-induced inhibition of thyroid-stimulating effects of oxytocin in rats

Makina

Krasnovskaya

1999

Bull Exp Biol Med

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In vivo and in vitro experiments on rats and isolated fragments of the thyroid gland showed 3H-oxytocin incorporation into thyrocytes followed by activation of the synthesis and release of thyroid hormones. Norepinephrine in vivo activates the thyroid gland, but combined action of norepinephrine and oxytocin suppressed in vivo and in vitro thyroid-stimulating effects of oxytocin. Key Words: thyroid gland; oxytocin; epinephrineVarious stress factors increase blood content of some hormones, responsible for the reaction to specific and nonspecific stress components. The increase in blood concentrations of catecholamine neurohormones of the adrenal medulla, epinephrine and norepinephrine (NE), is the major component of the hormonal reaction to stress. Hypothalamic nonapeptide hormones vasopressin and oxytocin (OT) are also released into the blood under the effect of various factors [4][5][6][7]. In light of this, combined effects of various neurohormones on target organs during stress are of considerable interest. In our previous experiments, we studied the reactions of rat thyroid gland (TG) in vivo [1] and thyrocytes in vitro [8] to combined action of vasopressin and epinephrine. However, there are no published data on the effects of combined treatment with OT and NE on mammalian TG. MATERIALS AND METHODSExperiments were performed on adult male Wistar rats weighing 140-160 g.In in vivo experiments, neurohormones and their combination were injected intraperitoneally 30 rain Laboratory of Neuroendocrinology, I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg before decapitation. The animals were divided into 4 groups (n=5) and injected with 1 ml physiological saline (control), 15 ng/100 g body weight OT, 30 ng/ 100 g body weight NE, and OT and NE in the same doses, respectively.After decapitation, TG was refnoved, fixed in Bouin's fluid, and subjected to routine histological treatment. The height of thyrocytes was measured on slices stained with azan by Heidenhain's method (x900).In vitro experiments were performed on 20 rats. Cross-sections (400 /.t) from the central zone of TG lobes were incubated in medium 199M saturated with carbogen (95% 02 and 5% CO2) at 37~ The medium was changed every 30 min. After 90-rain preincubation, the slices were transferred into the medium containing test neurohormones (60 min). We analyzed 5 groups of TG fragments incubated in media containing various neurohormones (100 pg/ml 3H-OT, 100 pg/ ml OT, 10 pM NE hydrotartrate, or both neurohormones in the same concentrations) or without neurohormones (control).All samples (except for those incubated with 3H-OT) were initially incubated in the medium containing 3H-leucine for 30 min. Some slices were then transferred into the medium without 3H-leucine, and others were further incubated with 3H-leucine. This method allows to assess the dynamics of thyroglobulin formation in thyrocytes and to determine the intensity of its transfer into the colloid or release from follicles [3,12,1...

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Section: Resultsmentioning

confidence: 56%

Norepinephrine-induced inhibition of thyroid-stimulating effects of oxytocin in rats

Makina

Krasnovskaya

1999

Bull Exp Biol Med

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Influence of Thyroid Hormones and Cortisol on Immune Response in Case of Children’s Bronchopulmonary Diseases

Smiyan

Loboda

Havrylenko

et al. 2021

EUMJ

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The problem of acute respiratory tract infections (including acute bronchitis) remains urgent in the whole world independent of human age, especially when disease rates are considered. The World Health Organization reports annually on 1.5 billion cases of acute respiratory diseases. In Ukraine, the disease rate is 3.6 times higher among children than among adults (totally, it is equal to 67,000 cases per 100,000 individuals). The highest rate is observed among under-6-year-old children. In contrast to the average bronchopulmonary disease rate in Europe, the same Ukrainian index remains slightly higher for the last decades. Among children, the acute bronchitis rate is 6.2–25.0% within all bronchopulmonary diseases, reaching 50.0–90.0% if there are recurrences. Our literature review aims to compare different researchers’ perspectives, selecting articles and analyzing data as to how thyroid hormones and cortisol influence immune response in children’s bronchopulmonary diseases. In the literature review, the modern perspective of children’s hormonal state in bronchopulmonary diseases is studied. The hypothalamus-hypophysis-thyroid and hypothalamus-hypophysis-paranephros interaction roles in bronchopulmonary adaptive responses are explained. The thyroid hormone and cortisol importance for organism resistance are regarded. The manifestation, pathogenetic progress mechanisms, diagnosing methods, and treatment of different subclinical hormonal shifts (particularly euthyroid sick syndrome) are researched. The interconnection of hormonal and immunological indicators is covered (whose change is a predictively significant marker – that can foresee the disease progress, its duration and consequences for patients). Therefore, the relevance consists in researching the influence of thyroid hormones and cortisol on immune response by different pathological states of children’s bronchopulmonary diseases.

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The inhibitory effect of noradrenaline on thyrotrophin-stimulated 3,5,3′-tri-iodothyronine and thyroxine release is mediated through a Ca2+-dependent process in the thyroid gland of the mouse

Cited by 2 publications

References 21 publications

Norepinephrine-induced inhibition of thyroid-stimulating effects of oxytocin in rats

Norepinephrine-induced inhibition of thyroid-stimulating effects of oxytocin in rats

Influence of Thyroid Hormones and Cortisol on Immune Response in Case of Children’s Bronchopulmonary Diseases

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