The Inhibitory Effect of Lithium on Thyroid Hormone Release in Both Euthyroid and Thyrotoxic Patients

Spaulding, Stephen W.; Burrow, Gerard N.; Bermudez, Francisco; Himmelhoch, Jonathan M.

doi:10.1210/jcem-35-6-905

Cited by 136 publications

(46 citation statements)

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“…Previous observations indicated that lithium inhibits the release of radioiodine from the thyroid, thereby prolonging the biological half-life of 131 1 (Sedvall et al 1968;Berens et al 1970;Spaulding et al 1972;Turner et al 1976). Our increase in the thyroid biological half-life of 131 1 is in agreement with these findings.…”

Section: Discussionsupporting

confidence: 92%

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Effect of Short-term and Long-term Lithium Treatment on Uptake and Retention of 10dine-131 in Rat Thyroid

Dhawan¹,

Sharma²,

Sharma³

et al. 1988

Aust. Jnl. Of Bio. Sci.

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Section: Discussionsupporting

confidence: 92%

“…Earlier studies (Burrow et al 1971;Spaulding et al 1972) showed that the administration of lithium increased the retention of 131 1 in the thyroid gland. These observations were further confirmed by Turner et al (1976).…”

Section: Discussionmentioning

confidence: 98%

Effect of Short-term and Long-term Lithium Treatment on Uptake and Retention of 10dine-131 in Rat Thyroid

Dhawan¹,

Sharma²,

Sharma³

et al. 1988

Aust. Jnl. Of Bio. Sci.

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“…Lithium inhibits the formation and release of thyroid hormone [1][2][3][4], and has produced hypothyroidism. However, lithium-induced thyrotoxicosis may also occur [5][6][7].…”

mentioning

confidence: 99%

“…Lithium carbonate alters thyroid function and has been reported to induce hypothyroidism [1][2][3][4]. Somewhat surprisingly, thyrotoxicosis has also been attributed to lithium administration [5][6][7].…”

mentioning

confidence: 99%

Acute Adrenal Insufficiency after Unilateral Adrenalectomy in Cushing's Syndrome: Precipitation by Lithium-Induced Thyrotoxicosis during Cortisol Replacement.

et al. 1994

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“…Lithium has been reported to inhibit the release of thyroxine from the thyroid glands [17]. Moreover, lithium has been reported to affect the immune system [18,19].…”

Section: Discussionmentioning

confidence: 99%

Anti-Eye Muscle Antibodies and Hypothyroid Graves' Disease: A Case Report.

et al. 1992

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Abstract. We report the case of a 70-year-old man who developed hypothyroidism associated with TSH receptor antibodies and severe ophthalmopathy during lithium therapy. He had received lithium therapy for more than 20 years for manic depression, when ophthalmopathy (class VI of the American Thyroid Association classification) and mild hypothyroidism developed. Orbital magnetic resonance imaging indicated marked enlargement of the superior, medial and inferior rectus muscles in the left eye. He had anti-eye muscle antibodies in his serum, detected by Western blotting and quantified by chromatoscanning, as well as anti-TSH receptor antibodies. He was treated with supplementation of levothyroxine and four cycles of methylprednisolone pulse therapy. After the pulse therapy, both anti-eye muscle antibodies and anti-TSH receptor antibodies decreased and disappeared in parallel with the improvement in eye symptoms and signs. These observations suggest the importance of anti-eye muscle antibodies as clinical markers in the development of thyroid-associated ophthalmopathy.

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The Inhibitory Effect of Lithium on Thyroid Hormone Release in Both Euthyroid and Thyrotoxic Patients

Cited by 136 publications

References 0 publications

Effect of Short-term and Long-term Lithium Treatment on Uptake and Retention of 10dine-131 in Rat Thyroid

Effect of Short-term and Long-term Lithium Treatment on Uptake and Retention of 10dine-131 in Rat Thyroid

Acute Adrenal Insufficiency after Unilateral Adrenalectomy in Cushing's Syndrome: Precipitation by Lithium-Induced Thyrotoxicosis during Cortisol Replacement.

Anti-Eye Muscle Antibodies and Hypothyroid Graves' Disease: A Case Report.

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