The inhibitory effect of barbituric acid on glucose- and tolbutamide-stimulated insulin secretion in the rat

Wright, Gary A.; Mennear, John H.

doi:10.1016/s0041-008x(77)80045-8

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Theoretically, induction of anesthesia may disrupt pulsatile insulin release either through effects on the putative pacemaker or by disrupting the mechanism that facilitates islet-to-islet coordination. Extrinsic denervation of the pancreas, which occurs in an isolated perfused pancreas (36,37) or a transplanted pancreas (20,35), does not ablate and appears to increase the frequency of coordinate pulsatile insulin secretion (35) (analogous to the denervated heart). However, the intrinsic intraorgan neural network also appears to be important (analogous to Purkinje tissue), as intrahepatic transplanted islets in diabetic rats only achieve coordinate pulsatile insulin release once reinnervated by the intrahepatic neural network (25).…”

Section: Discussionmentioning

confidence: 99%

Anesthesia rapidly suppresses insulin pulse mass but enhances the orderliness of insulin secretory process

Vore

Aycock

Veldhuis

et al. 2001

American Journal of Physiology-Endocrinology and Metabolism

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Induction of anesthesia is accompanied by modest hyperglycemia and a decreased plasma insulin concentration. Most insulin is secreted in discrete pulses occurring at approximately 6- to 8-min intervals. We sought to test the hypothesis that anesthesia inhibits insulin release by disrupting pulsatile insulin secretion in a canine model by use of direct portal vein sampling. We report that induction of anesthesia causes an abrupt decrease in the insulin secretion rate (1.1 +/- 0.2 vs. 0.7 +/- 0.1 pmol. kg(-1). min(-1), P < 0.05) by suppressing insulin pulse mass (630 +/- 121 vs. 270 +/- 31 pmol, P < 0.01). Anesthesia also elicited an approximately 30% higher increase in insulin pulse frequency (P < 0.01) and more orderly insulin concentration profiles (P < 0.01). These effects were evoked by either sodium thiamylal or nitrous oxide and isoflurane. In conclusion, anesthesia represses insulin secretion through the mechanism of a twofold blunting of pulse mass despite an increase in orderly pulse frequency. These data thus unveil independent amplitude and frequency controls of beta-cells' secretory activity in vivo.

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Section: Discussionmentioning

confidence: 99%

Anesthesia rapidly suppresses insulin pulse mass but enhances the orderliness of insulin secretory process

Vore

Aycock

Veldhuis

et al. 2001

American Journal of Physiology-Endocrinology and Metabolism

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The effects of barbituric acid and 5-nitro barbituric acid on glycemic responses and in vitro insulin release in mice

Wright

Spratto

Mennear

1979

Toxicology and Applied Pharmacology

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Biochemical effects of some organo‐phosphorus insecticides on new targets in white rats

El‐Sebae

Enan

Soliman

et al. 1981

Journal of Environmental Science and Health, Part B

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The three S-n-propyl phosphates and phosphothioates: RH 218, profenofos and prothiophos were compared with fenitrothion in their potential as inhibitors of rat liver and brain AChE. Fenitrothion was more potent as an inhibitor than the three S-n-propyl derivatives. Incubation of hepatic protein enhanced ChE inhibition in brain in the case of fenitrothion, while it reduced the inhibitory effect of the S-n-propyl derivatives. On the other hand, the four organophosphorus esters caused hypoglycemia in both male and female rats and also reduced their blood urea with different degrees.

show abstract

The inhibitory effect of barbituric acid on glucose- and tolbutamide-stimulated insulin secretion in the rat

Cited by 3 publications

References 11 publications

Anesthesia rapidly suppresses insulin pulse mass but enhances the orderliness of insulin secretory process

Anesthesia rapidly suppresses insulin pulse mass but enhances the orderliness of insulin secretory process

The effects of barbituric acid and 5-nitro barbituric acid on glycemic responses and in vitro insulin release in mice

Biochemical effects of some organo‐phosphorus insecticides on new targets in white rats

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