The Inhibition of the Soluble Human Placental 17β-Hydroxysteroid Dehydrogenase by<i>o,p′</i>-DDD1 and Its Analogs

Jarabak, Joseph; Ma, S.F.

doi:10.1210/endo-89-6-1407

Cited by 8 publications

(2 citation statements)

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“…8. Substances of this type, particularly o,p'-DDD, may inhibit steroid synthesis (e.g., Brown et al, 1973;Hart et al, 1973;Jarabak and Sack, 1969;Jarabak and Street, 1971;Reznikov and Kravtsova, 1970). Also, these classes of compounds induce liver microsomal metabolism of steroids (e.g., Levin et al, 1969;Peakall, 1967;Welch et al, 1967Welch et al, , 1971, and they interact with the steroid receptors (this review; Lloyd et al, 1973Lloyd et al, , 1974Schein et al, 1977;Smith et al, 1972;Thomas et al, 1973).…”

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confidence: 99%

Estrogenlc activities of chlorinated hydrocarbons

Nelson¹,

Struck²,

James³

1978

Journal of Toxicology and Environmental Health

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Some DDT analogs are estrogenic, particularly o,p'-DDT, which comprises approximately 15-20% of the commercial DDT mixture. Whether this compound or its metabolites are active has not been established. In fact, the data obtained thus far are more confusing than enlightening. For example, CCl4 pretreatment of immature female rats has been reported to inhibit or enhance estrogenic activity of o,p'-DDT, and SKF-525A pretreatment has been reported to enhance or not alter the estrogenic effect. Although o,p'-DDT inhibits binding of estradiol to the estrogen receptor from rat or human at low levels (approximately 1-10 micrometer) in vitro, higher levels are required to inhibit nuclear binding of [3H] estradiol in incubated whole uteri. Futhermore, o,p'-DDT appears to be neither estrogenic nor antiestrogenic in an in vitro estrogen assay. Methoxychlor appears to be "activated" by metabolism, and it is probable that phenolic metabolites are responsible for its estrogenic activity. Since chlorinated hydrocarbons often enhance the metabolism of steroids and may reduce circulating levels of steroids, interactions of the exogenous hormonally active agents with steroid receptors may be self-potentiating in vivo.

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mentioning

confidence: 99%

Estrogenlc activities of chlorinated hydrocarbons

Nelson¹,

Struck²,

James³

1978

Journal of Toxicology and Environmental Health

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“…There are multiple stages which could induce slow denaturation or nonspecific aggregation during the purification process or during storage. It has been proven that loss of activity of 17␤-HSD1 is induced by aggregation (20,21,Han et al,unpublished). High temperature may thus recover or help maintain activity by preventing aggregation.…”

Section: High Temperature Increases the Reproducibility Of 17␤-hsd1 Cmentioning

confidence: 99%

The Study of Crystallization of Estrogenic 17β-Hydroxysteroid Dehydrogenase with DHEA and DHT at Elevated Temperature

Han

Lin

2000

Biochemical and Biophysical Research Communications

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Induction of Conditions Leading to Cancer in the Genital Tract by Estrogen During the Differentiation Phase of the Genital Epithelium

Forsberg¹

1974

Hormones and Embryonic Development

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The Inhibition of the Soluble Human Placental 17β-Hydroxysteroid Dehydrogenase byo,p′-DDD1 and Its Analogs

Cited by 8 publications

References 0 publications

Estrogenlc activities of chlorinated hydrocarbons

Estrogenlc activities of chlorinated hydrocarbons

The Study of Crystallization of Estrogenic 17β-Hydroxysteroid Dehydrogenase with DHEA and DHT at Elevated Temperature

Induction of Conditions Leading to Cancer in the Genital Tract by Estrogen During the Differentiation Phase of the Genital Epithelium

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