The inhibition of MARCO by PolyG alleviates pulmonary fibrosis via regulating mitochondrial function in a silicotic rat model
Meiyu Chang,
Ning Li,
Qiang Zhou
et al.
Abstract:Silicon dioxide (SiO2)‐induced pulmonary fibrosis is potentially associated with the impairment of mitochondrial function. Previous research found that inhibition of macrophage receptor with collagenous structure (MARCO) could alleviate particle‐induced lung injury by regulating phagocytosis and mitigating mitochondrial damage. The present study aims to explore the underlying anti‐fibrosis mechanism of polyguanylic acid (PolyG, MARCO inhibitor) in a silicotic rat model. Hematoxylin and eosin and Masson stainin… Show more
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