The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice

Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models

“…RSV effectively suppressed the growth of pancreatic cancer (PaCa) in an orthotopic mouse model through the downregulation of NF-κB, cyclin D1, COX-2, intercellular adhesion molecule-1 (ICAM-1), matrix metallopeptidase-9 (MMP-9), and survivin [8]. In addition, RSV upregulated the mRNA expression of p53 and extracellular signal-regulated kinase (ERK) in squamous cell carcinoma (A431) xenografts in nude mice [23].…”

New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms

“…Resveratrol doses arbitrated TGF- β 2 downregulation; this event appears to occur through the inhibition of both TGF- β 2/Smad dependent and independent pathways and thus suppressed the invasiveness of A431 cells [129]. Through the establishment of A431 cells xenografts in nude mice, Hao et al [130] noted that the anticancer mechanism of resveratrol was through inducing apoptosis as it altered p53 and survivin expression. In a study, Bastianetto et al [131] aimed to investigate the possible existence of specific binding sites in skin that mediate the protective action of resveratrol.…”

Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity

“…It has been extensively studied for its antioxidant, anti-aging and anti-inflammatory activities181920212223. In addition, in vivo and in vitro studies showed that RES possesses potential anti-tumor activity against several malignancies24252627. According to our previous study, RES potentiates the cytotoxic properties of DOX in MCF-7, HeLa and HepG2 cells via P-gp inhibition and downregulation of MDR1 gene28.…”