The Inhibition of Neuraminidase and Antiviral Action

Edmond, J. D.; Johnston, Richard; Kidd, D. A. A.; Rylance, H. J.; Sommerville, R. G.

doi:10.1111/j.1476-5381.1966.tb01673.x

Cited by 63 publications

(25 citation statements)

References 21 publications

(12 reference statements)

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“…A screening program for neuraminidase inhibitors was undertaken by Edmond et al (1966) in the belief that such compounds could have antiviral activity. No potent compounds were iden-tified in that study, the best being N-phenyloxamic acid and some of its derivatives.…”

Section: Inhibitorsmentioning

confidence: 99%

Influenza virus neuraminidase: Structure, antibodies, and inhibitors

Colman¹

1994

Protein Science

316

224

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The determination of the 3-dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti-influenza virus drug.

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Section: Inhibitorsmentioning

confidence: 99%

Influenza virus neuraminidase: Structure, antibodies, and inhibitors

Colman¹

1994

Protein Science

316

224

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“…Early attempts at the development of inhibitors of influenza virus NA resulted in oxamic acid derivatives being studied [27], wherein their activity was rationalized by comparison with SA using the carboxylate moiety as a common structural feature. Several compounds were subsequently investigated as NA inhibitors based on the results of random screening poor potency, lack of selectivity, or lack of in vivo activity.…”

Section: Function Of Neuraminidase (Na)mentioning

confidence: 99%

Recent Advances in Anti-Influenza Agents with Neuraminidase as Target

Zhang¹,

2006

MRMC

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Neuraminidase (NA) is the major surface glycoprotein of the influenza virus. It has been considered a suitable target for designing agents against influenza viruses. Rational drug design of NA inhibitors is now in the clinic and is effective for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review a series of neuraminidase inhibitors and the recent progress in this field.

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“…

With the objective of finding new biologically active compounds based on isatin 1 and 3,4-diaminofurazane 2 as nucleophilic reagent we have synthesized heterocycles containing indole and furazane rings at the same time.

…”

mentioning

confidence: 99%

“…Many dyes, plant growth stimulators, analytical reagents, and medical preparations have been obtained based on isatin [1][2][3]. The furazane ring is found in energy-rich materials, intermediates in organic synthesis, and biologically active compounds [4,5].…”

mentioning

confidence: 99%

Interaction of spiro-heterocyclic oxindole system with sodium diformylimide

Гуревич

Саттарова

Petrovskiy

et al. 2011

Chem Heterocycl Comp

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New functionalized condensed benzazoles have been synthesized based on isatin, 3,4-diaminofurazane, and sodium diformylimide.Many dyes, plant growth stimulators, analytical reagents, and medical preparations have been obtained based on isatin [1][2][3]. The furazane ring is found in energy-rich materials, intermediates in organic synthesis, and biologically active compounds [4,5].With the objective of finding new biologically active compounds based on isatin 1 and 3,4-diaminofurazane 2 as nucleophilic reagent we have synthesized heterocycles containing indole and furazane rings at the same time. The interaction of compounds 1 and 2 was carried out by boiling in acetonitrile. The reaction did not occur at room temperature which is probably connected with the low nucleophilicity of the amino groups in 3,4-diaminofurazane.The course of the reaction was monitored by the disappearance in the IR spectrum of the C=O vibration in position 3 of isatin and by TLC. The reaction mixture became darker during the course of the reaction. Analytically pure compound 3 was obtained by column chromatography with subsequent recrystallization from absolute ethanol. The spiro compound 3 was isolated in 77% yield.

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The Inhibition of Neuraminidase and Antiviral Action

Cited by 63 publications

References 21 publications

Influenza virus neuraminidase: Structure, antibodies, and inhibitors

Influenza virus neuraminidase: Structure, antibodies, and inhibitors

Recent Advances in Anti-Influenza Agents with Neuraminidase as Target

Interaction of spiro-heterocyclic oxindole system with sodium diformylimide

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