The inhibition of GLUT1-induced glycolysis in macrophage by phloretin participates in the protection during acute lung injury

Songyang, Yiyan; Wen, Lai; Li, Wenqiang; Yang, Ji An; Song, Tianbao

doi:10.1016/j.intimp.2022.109049

Cited by 10 publications

(1 citation statement)

References 30 publications

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“…Many novel approaches, being in the preclinical development, aim to target metabolic reprogramming to stop inflammation and fibrosis. For instance, inhibition of GLUT1 by a natural substance, phloretin, in macrophages, is found to be effective in mouse models of acute lung injury ( 48 ) and bleomycin-induced lung fibrosis ( 49 ). Moreover, anlotinib, a multitargeted tyrosine inhibitor drug, is found to reduce activation of PFKB3 and subsequently glycolysis during fibroblast activation ( 44 ).…”

Section: Increased Glucose Uptake As a Marker Of A Pulmonary Fibrosis...mentioning

confidence: 99%

Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases

Drzewicka,

Zasłona

2024

Front. Immunol.

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Metabolic changes are coupled with alteration in protein glycosylation. In this review, we will focus on macrophages that are pivotal in the pathogenesis of pulmonary fibrosis and sarcoidosis and thanks to their adaptable metabolism are an attractive therapeutic target. Examples presented in this review demonstrate that protein glycosylation regulates metabolism-driven immune responses in macrophages, with implications for fibrotic processes and granuloma formation. Targeting proteins that regulate glycosylation, such as fucosyltransferases, neuraminidase 1 and chitinase 1 could effectively block immunometabolic changes driving inflammation and fibrosis, providing novel avenues for therapeutic interventions.

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Section: Increased Glucose Uptake As a Marker Of A Pulmonary Fibrosis...mentioning

confidence: 99%

Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases

Drzewicka,

Zasłona

2024

Front. Immunol.

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Phloretin targets SIRT1 to alleviate oxidative stress, apoptosis, and inflammation in deep venous thrombosis

Wang,

Yan,

et al. 2023

Toxicol Res.

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GLUT1 Promotes NLRP3 Inflammasome Activation of Airway Epithelium in Lipopolysaccharide-Induced Acute Lung Injury

Li,

Chen

et al. 2024

The American Journal of Pathology

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The inhibition of GLUT1-induced glycolysis in macrophage by phloretin participates in the protection during acute lung injury

Cited by 10 publications

References 30 publications

Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases

Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases

Phloretin targets SIRT1 to alleviate oxidative stress, apoptosis, and inflammation in deep venous thrombosis

GLUT1 Promotes NLRP3 Inflammasome Activation of Airway Epithelium in Lipopolysaccharide-Induced Acute Lung Injury

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