The Inhibition of Frostbite Wheals by the Iontophoresis of Antihistaminic Agents 1

Macht, Martin B.; Bader, Mortimer E.; Mead, J.; Pillion, Elizabeth L.

doi:10.1172/jci102106

Cited by 3 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Frommel and Piquet in 1946 treated frostbite of the legs of guinea pigs with an antihistaminic with beneficial effects (16). Macht and his associates (17) found that when areas of skin of volunteer subjects were subjected to iontophoresis with antihistaminics and were then subjected to spot-freezing, fewer vesicles developed than in the controls and the wheals were somewhat delayed in appearance and were less severe. In my laboratory the administration of benadryl following frostbite gave results which were comparable to those just mentioned in the case of rutin (6).…”

Section: The Present Status Of the Treatment Of Frostbitementioning

confidence: 99%

The Present Status of the Treatment of Frostbite

Shumacker

1951

Angiology

View full text Add to dashboard Cite

The evolution of an effective program for the treatment of frostbite has been beset with unusual difficulties. For one thing, we have inherited a literature weighty with authority but largely based upon folklore and arm-chair philosophy rather than upon sound deductions from objective clinical and experimental data. It has been necessary, therefore, not only to attempt to develop new rational methods based upon controlled observations, but at the same time to overthrow erroneously conceived, but firmly established, dogma. For another thing, proper evaluation of therapy in human frostbite has been particularly difficult because of the relative dearth of material for study in times of peace and the impediments to careful clinical experimentation imposed by the exigencies of war. At the same time the variable character of the injury and the impossibility of reasonably accurate early prediction of the eventual outcome in any given case make requisite ample clinical material and its most careful study.Finally, though animal experimentation has the advantage of providing limitless numbers of subjects for study and of permitting adequate control observations, it has thus far proved to be an apparently reliable guide to treatment only in relation to the prevention of gangrene. It has added nothing to the management of the various vasomotor disturbances which constitute the commonest sequelae in man. The treatment of these sequelae in man is, to be sure, not nearly so difficult a problem as the early management of frostbite and the prevention of tissue damage. Animal experimentation, furthermore, has made possible invaluable contributions to our understanding of the functional pathology of frostbite and gives promise of adding new information about acclimatization and prophylaxis.In spite of the difficulties which have been mentioned real progress has been made in recent years in bringing about a better comprehension of the basic problem and a more rational approach to treatment. In this communication I shall limit my remarks to true frostbite and the related less severe injuries resulting from exposure to more or less dry freezing temperatures.

show abstract

Section: The Present Status Of the Treatment Of Frostbitementioning

confidence: 99%

The Present Status of the Treatment of Frostbite

Shumacker

1951

Angiology

View full text Add to dashboard Cite

show abstract

“…Though more variable and less striking results were obtained with heparinization and with the production of vasodilatation by sympathetic denervation, these methods appeared to be of some definite value (1,2,3). The present studies are concerned with an evaluation of several other methods which recent reports have suggested may alter the course of events after experimental frostbite (4,5,6).…”

mentioning

confidence: 99%