The influx of calcium ions into human erythrocytes during cold storage. The influences of extracellular pH, intracellular adenosine triphosphate and efflux of univalent cations
Abstract:1. When human erythrocytes are stored at 3°C for several days as a suspension in isoosmotic sucrose or KCI, containing CaCl2, the rates of cellular ATP degradation are similar. 2. During cold storage oferythrocytes in sucrose-CaCl2 medium, Ca2+ influx and univalent-cation efflux occur, the pH value of the suspending medium rises and the intracellular pH falls. These pH changes correlate reasonably well with alterations in the membrane potential calculated from Cl-distribution. 3. The presence of Ca2+ in the me… Show more
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