The influence of wound geometry on the measurement of wound healing rates in clinical trials

Abstract

Linear healing per day is a valid means of comparing wound healing rates in wounds of different dimensions. Linear healing per unit of time should be preferred to measurements of change in wound area to quantify wound healing rates in clinical trials.

Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair

“…Owing to the difference in wound size, the percentage of epithelialization appeared to be lower in Postn 2/2 wounds (not significant), yet the epithelial migration distance was actually higher. Therefore we feel that percentage epithelialization is an inappropriate measurement for wounds of different sizes (Gorin et al, 1996) and epithelial migration distance is the more reliable method.…”

Management of venous leg ulcers: Clinical practice guidelines of the Society for Vascular Surgery® and the American Venous Forum

“…[102][103][104][105][106][107][108][109][110][111][112][113] There is no evidence to support routine microbiology surface cultures of VLU in the absence of clinical signs of infection as these wounds are usually colonized by multiple micro-organisms. If there are no clinical signs of infection and the wound is responding to treatment, there is no indication to culture the wound.…”

A Simple Mathematical Model for Wound Closure Evaluation

“…26 However, both the patient's health condition and the wound shape have been invoked to explain differences in healing rates. 14,15,17 In this study, null or weak correlations have been found between D c or D avg in terms of wound size and shape, parameterized by means of A, P, and S c , or with the patient's condition.…”

“…3,[7][8][9][10][11][12][13] However, controversy exists in the selection of the adequate indicative parameter of the wound closure rate. 8,9,14,15 Assessment of wound status in terms of time is often based on measurements of wound area and, to a lesser extent, of the wound perimeter 8,[14][15][16][17] and the linear healing rate (D) has been often utilized. The D parameter is obtained through a method of calculation based on differences; thus, accurate calculation requires a large number of data to achieve statistical significance.…”