The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats

Thomaz, Fernanda S.; Altemani, Faisal H.; Panchal, Sunil K.; Worrall, Simon; Nitert, Marloes Dekker

doi:10.1038/s41371-020-0359-8

Cited by 17 publications

(20 citation statements)

References 51 publications

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“…Higher abundance of genus Desulfovibrio observed in the Ang II group was in agreement with the previous reports of other hypertensive rodent models and human patients (Adnan et al, 2017;Li et al, 2017;Dan et al, 2019;Thomaz et al, 2021). Desulfovibrio abundance is also positively correlated with Ang II levels in rats with highcarbohydrate, high-fat diet-induced HTN (Thomaz et al, 2021). These and our findings further support the possible involvement of SRB in HTN.…”

Section: Discussionsupporting

confidence: 93%

“…The genus Desulfovibrio in the Deltaproteobacteria class is one of the most abundant sulfate-reducing bacteria (SRB) in the human colon ( Dordevic et al, 2021 ). Higher abundance of genus Desulfovibrio observed in the Ang II group was in agreement with the previous reports of other hypertensive rodent models and human patients ( Adnan et al, 2017 ; Li et al, 2017 ; Dan et al, 2019 ; Thomaz et al, 2021 ). Desulfovibrio abundance is also positively correlated with Ang II levels in rats with high-carbohydrate, high-fat diet–induced HTN ( Thomaz et al, 2021 ).…”

Section: Discussionsupporting

confidence: 93%

“…To the best of our knowledge, no study to date has reported an association between Dehalobacterium and HTN, but a positive correlation between the abundance of Dehalobacterium and obesity and higher body mass index, which are also associated with HTN ( Jones et al, 1994 ; Wilson et al, 2002 ; Zhang et al, 2019 ), has been previously reported ( Fu et al, 2015 ; Thomaz et al, 2021 ). Here, we observe that central administration of NaHS normalized the levels of Desulfovibrio , Deltaproteobacteria , and Dehalobacterium in Ang II-infused rats.…”

Section: Discussionmentioning

confidence: 86%

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Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension

et al. 2021

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Hydrogen sulfide (H2S) is a gaseous signaling molecule with neuromodulatory, anti-inflammatory, and anti-hypertensive effects. Here, we investigate whether chronic intracerebroventricular (ICV) infusion of sodium hydrosulfide (NaHS), an H2S donor, can alleviate angiotensin II (Ang II)–induced hypertension (HTN), improve autonomic function, and impact microglia in the paraventricular nucleus (PVN) of the hypothalamus, a brain region associated with autonomic control of blood pressure (BP) and neuroinflammation in HTN. Chronic delivery of Ang II (200 ng/kg/min, subcutaneous) for 4 weeks produced a typical increase in BP and sympathetic drive and elevated the number of ionized calcium binding adaptor molecule 1–positive (Iba1+) cells in the PVN of male, Sprague–Dawley rats. ICV co-infusion of NaHS (at 30 and/or 60 nmol/h) significantly attenuated these effects of Ang II. Ang II also increased the abundance of cecal Deltaproteobacteria and Desulfovibrionales, among others, which was prevented by ICV NaHS co-infusion at 30 and 60 nmol/h. We observed no differences in circulating H2S between the groups. Our results suggest that central H2S may alleviate rodent HTN independently from circulating H2S via effects on autonomic nervous system and PVN microglia.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 86%

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Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension

et al. 2021

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“…S247 , Uncl. Coriobacteriaceae , and Bifidobacterium [ 93 ]. Moreover, treatment with anthocyanins extracted from Lycium ruthenicum Murray could not only improve oxidative stress and inflammation in C57BL/6 mice but also promote the proliferation of Barnesiella , Alistipes , Eisenbergiella , Coprobacter , and Odoribacter and increase the production of SCFA in cecal and feces [ 94 ].…”

Section: Experimental Studiesmentioning

confidence: 99%

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Zhou

Luo

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Cardiovascular diseases (CVDs) have gained increasing attention because of their high prevalence and mortality worldwide. Epidemiological studies revealed that intake of fruits, vegetables, nuts, and cereals could reduce the risk of CVDs, and their antioxidants are considered as the main contributors. Moreover, experimental studies showed that some antioxidant natural products and their bioactive compounds exerted beneficial effects on the cardiovascular system, such as polyphenols, polysaccharides, anthocyanins, epigallocatechin gallate, quercetin, rutin, and puerarin. The mechanisms of action mainly included reducing blood pressure, improving lipid profile, ameliorating oxidative stress, mitigating inflammation, and regulating gut microbiota. Furthermore, clinical trials confirmed the cardiovascular-protective effect of some antioxidant natural products, such as soursop, beetroot, garlic, almond, and green tea. In this review, we summarized the effects of some antioxidant natural products and their bioactive compounds on CVDs based on the epidemiological, experimental, and clinical studies, with special attention paid to the relevant mechanisms and clinical trials.

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“…Meanwhile their combination also increased Coriobacteriaceae abundance. It was confirmed that HFD causes Rikenellaceace and Coriobacteriaceae reduction, and the restoration should be beneficial in anti-obesity treatment (Alard et al, 2016;Clarke et al, 2013;Thomaz et al, 2020). Furthermore, Coriobacteriaceae abundance is found to be positively correlated with GLP-1 secretion, the latter of which contributes to glucose homeostasis (Cornejo-Pareja et al, 2019).…”

Section: Discussionmentioning

confidence: 94%

Ginsenoside Rb1, salvianolic acid B and their combination modulate gut microbiota and improve glucolipid metabolism in high-fat diet induced obese mice

Bai

Bao

et al. 2021

PeerJ

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Background To observe the effect of ginsenoside Rb1, salvianolic acid B and their combination on glucolipid metabolism and structural changes of gut microbiota. Methods Eight-week-old C57BL/6J mice were fed 45% high-fat diet to induce obesity. The obese mice were randomly divided into four groups, Con group as model control, ginsenoside Rb1 (Rb1) group, salvianolic acid B (SalB) group and ginsenoside Rb1+ salvianolic acid B (Rb1SalB) group. Mice in Rb1, SalB and Rb1SalB group were treated by gavage with ginsenoside Rb1, salvianolic acid B and the combination of the two ingredients, respectively. While mice in Con group were given the same amount of sterile water. The intervention lasted 8 weeks. Body weight and fasting blood glucose were measured every 2 weeks. Oral glucose tolerance test was conducted on the 4th and 8th week of drug intervention. At the end of the experiment, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and non-esterified fatty acid content as well as glycated hemoglobin were measured and feces were collected for 16S rDNA sequencing. Results Both ginsenoside Rb1 and Rb1SalB combination decreased body weight significantly (P < 0.05). Ginsenoside Rb1, salvianolic acid B and their combination alleviated fasting blood glucose, glycated hemoglobin and blood lipid profiles effectively (P < 0.05, compared with the corresponding indicators in Con group). Oral glucose tolerance test results at the 8th week showed that glucose tolerance was significantly improved in all three treatment groups. Ginsenoside Rb1, salvianolic acid B and their combination reduced the overall diversity of gut microbiota in feces and changed the microbial composition of the obese mice. LDA effect size (LefSe) analysis revealed the key indicator taxa corresponding to the treatment. Conclusion Ginsenoside Rb1, salvianolic acid B and their combination could lower blood glucose and lipid level, and improve glucose tolerance of obese mice. The above effect may be at least partially through modulation of gut microbial composition.

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The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats

Cited by 17 publications

References 51 publications

Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension

Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Ginsenoside Rb1, salvianolic acid B and their combination modulate gut microbiota and improve glucolipid metabolism in high-fat diet induced obese mice

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