THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A&gt;G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN

Maylyan, E. A.

doi:10.21886/2219-8075-2016-4-32-38

Cited by 8 publications

(1 citation statement)

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“…The study enrolled 65 patients females the mean age of all subjects was 64. 16 which confirmed that fractures rise exponentially with advancing age, also Albrand et al 17 in a cohort study of 672 healthy postmenopausal women established that age 65 or more is an independent risk factor for developing fractures.…”

Section: Discussionmentioning

confidence: 69%

Assessment of Risk of Fracture among obese elderly women attending primary health clinic at geriatric hospital in Ain Shams University Hospitals

Kader

2021

The Egyptian Journal of Geriatrics and Gerontology

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Section: Discussionmentioning

confidence: 69%

Assessment of Risk of Fracture among obese elderly women attending primary health clinic at geriatric hospital in Ain Shams University Hospitals

Kader

2021

The Egyptian Journal of Geriatrics and Gerontology

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The role of genetic and metabolic disorders in osteoporosis

Васильева

Bezzubtseva

Gosteva

et al. 2021

Med. vestn. Ûga Ross.

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Osteoporosis is a progressive multifactorial systemic disease of the skeletal system characterized by the damage of the microarchitectonics of the bone tissue, which leads to the occurrence of low-energy fractures and impairment of the quality of life of individuals. The risk factors for the development of osteoporosis include smoking, which inhibits calcium absorption in the intestine and not only contributes to the reduction of bone density but also acts as a predictor of bronchopulmonary pathology. The systemic inflammation that develops in patients with chronic obstructive pulmonary disease, associated with the production of interleukins (IL)-6, IL-1, IL-8, and tumor necrosis factor – α, stimulates osteoclast-mediated bone resorption and a low level of osteoprotegerin closes the circle. In clinical practice, the determination of markers of bone resorption is required. This is a tartrate-resistant acid phosphatase, the 5β fraction of which signals the end of the resorption process; these are hydroxypyridine crosslinks – pyridoline (PYD) and deoxypyridoline, that stabilize the bone collagen molecule. Genetic factors also play an important role in the development of osteoporosis. The presence of the GG genotype or the G allele of the 283 A> G polymorphism (Bsml) of the VDR gene is a predictor of osteoporosis of the lumbar vertebrae L1-L4. The substitution of cytosine for thymine (C> T) in exon 17 of the calcitonin gene (CALCR) at position 1340 leads to the substitution of the amino acid proline (CCG) for leucine (CTG) at position 463 of the receptor protein molecule and affects bone density. But the most phylogenetically ancient mechanism for regulating the development and maintenance of tissue homeostasis by controlling cell proliferation, differentiation, migration, and apoptosis is the Wnt signaling pathway (SP-Wnt). Alterations in Wnt signaling observed in cases of genetic mutations cause various diseases of the human skeleton. A systematic literature search was carried out using the Scopus, PubMed, Web of Science databases.

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Bsmi Polymorphism of Vitamin D Receptor Gene and Efficiency of Post- Menopausal Osteoporosis Treatment by Ibandronic Acid

Резниченко

Adunts²

2022

Tavricheskiy Mediko-Biologicheskiy Vestnik

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An assessment of genetic factors influence on ibandronic acid effect in postmenopausal osteoporosis treatment can significantly bring us closer to the practical use of this results in prognostic genetics and personalized medicine. The aim was the study of associations between 283 A>G (BsmI, rs1544410) polymorphisms of vitamin D receptor gene (VDR) and ibandronic acid efficacy in postmenopausal osteoporosis treatment. 117 women with postmenopausal osteoporosis were examined through treatment dynamics. A 12-month therapy course included the use of ibandronic acid according to standard regimen. Evaluation of treatment effectiveness was carried out by changes (%) in bone mineral density (BMD) separately for each area by dual- energy X-ray absorptiometry. Real-time PCR was used to determine VDR gene rs1544410 polymorphism. It was found that for 12 months ibandronate use caused significant (p<0.001) BMD increase. BMD increase ranged from 2.71±0.53% in left femoral neck zone to 4.63±0.53% in the L1-L4 lumbar vertebrae. The treatment outcome did not depend (p>0.05) on age, height, weight, body mass index, and postmenopause duration. GG genotype of rs1544410 polymorphism was associated with lower BMD growth rate in L1-L4 lumbar vertebrae (p=0.036). Screening of women with postmenopausal osteoporosis for polymorphic variants of VDR gene (rs1544410) before antiresorptive therapy with ibandronic acid may be appropriate to predict the effect and individualize treatment and prophylactic measures. The obtained results can contribute to more complete understanding of osteoporosis pharmacogenetics

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THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN

Cited by 8 publications

References 0 publications

Assessment of Risk of Fracture among obese elderly women attending primary health clinic at geriatric hospital in Ain Shams University Hospitals

Assessment of Risk of Fracture among obese elderly women attending primary health clinic at geriatric hospital in Ain Shams University Hospitals

The role of genetic and metabolic disorders in osteoporosis

Bsmi Polymorphism of Vitamin D Receptor Gene and Efficiency of Post- Menopausal Osteoporosis Treatment by Ibandronic Acid

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