The influence of visual deprivation on the development of the thalamocortical network: Evidence from congenitally blind children and adults

Lin, Jiaping; Zhang, Linjun; Guo, Runhua; Jiao, Saiyi; Song, Xinshan; Feng, Suting; Wang, Ke; Li, Mingyang; Luo, Yudan; Han, Zaizhu

doi:10.1016/j.neuroimage.2022.119722

Cited by 4 publications

(5 citation statements)

References 127 publications

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“…In the relationship between the thalamus and VN, visual deprivation disrupts the thalamocortical network in the visual-spatial integration task [68]. Blindness disrupts and reorganizes the connectivity between the thalamus and VN [69]. A previous study has reported synchronized opposite activations between the thalamus and cortical regions in the behavioral state [70], and 129 our resting-state study further indicates that the opposite activation is widespread in resting brain dynamics.…”

Section: Discussionsupporting

confidence: 72%

“…In addition, the thalamocortical activity has demonstrated high spatiotemporal dynamics to flexibly change brain states [66] and plays a critical role in the regulation of adaptive sensory functions [67]. In the relationship between the thalamus and VN, visual deprivation disrupts the thalamocortical network in the visual–spatial integration task [68]. Blindness disrupts and reorganizes the connectivity between the thalamus and VN [69].…”

Section: Discussionmentioning

confidence: 99%

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Cortico–subcortical spatiotemporal dynamics in Parkinson’s disease can be modulated by transcranial alternating current stimulation

Liu

Yan

Han

et al. 2023

Brain Science Advances

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Objective: We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms of transcranial alternating current stimulation (tACS) in patients with Parkinson’s disease (PD). Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 20 patients with PD and 20 normal controls (NC). Each patient with PD received successive multidisciplinary intensive rehabilitation treatment and tACS treatment over a one-year interval. Individual functional brain network mapping and co-activation pattern (CAP) analysis were performed to characterize cortico–subcortical dynamics. Results: The same tACS electrode placement stimulated different proportions of functional brain networks across the participants. CAP analysis revealed that the visual network, attentional network, and default mode network co-activated with the thalamus, accumbens, and amygdala, respectively. The pattern characterized by the de-activation of the visual network and the activation of the thalamus showed a significantly low amplitude in the patients with PD than in NCs, and this amplitude increased after tACS treatment. Furthermore, the co-occurrence of cortico–subcortical CAPs was significantly higher in patients with PD than in NCs and decreased after tACS treatment. Conclusions: This study investigated cortico–subcortical spatiotemporal dynamics in patients with PD and further revealed the tACS treatment mechanism. These findings contribute to understanding cortico– subcortical dynamics and exploring noninvasive neuromodulation targets of cortico–subcortical circuits in brain diseases, such as PD, Alzheimer’s disease, and depression.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Cortico–subcortical spatiotemporal dynamics in Parkinson’s disease can be modulated by transcranial alternating current stimulation

Liu

Yan

Han

et al. 2023

Brain Science Advances

View full text Add to dashboard Cite

show abstract

“…Indeed, experience-dependent matching of stimulus selectivity of the visual input from the two eyes occurs during the critical period [ 22 ]. Changes in the microstructure of white matter tracts have been found in late-blind subjects when compared to the congenitally blind or sighted controls [ 23 , 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…Additional research with congenitally blind adults confirmed these findings. Magnetoencephalography was also used to collect the data of congenitally blind and sighted humans in another study [ 25 ]. Deprivation-related changes in spectral profiles were mapped to the cortex using clustering and classification procedures.…”

Section: Resultsmentioning

confidence: 99%

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Anatomical and Functional Impacts of Congenital Bilateral Visual Deprivation on the Visual Pathway—A Comprehensive Review

Czarnek-Chudzik,

Toro,

Rejdak

et al. 2024

JCM

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Neuroplasticity is a complex process that is heightened during time-sensitive periods of pre- and postnatal brain development. It continues, albeit to a lesser extent, throughout adolescence and young adulthood. Congenital visual deprivation is well-known and explored in human-model behavioral research. In this study, we review existing research on neuroadaptations and neuroplasticity of the visual pathway as a result of inherited retinal diseases (IRD), focusing on data concerning congenital bilateral visual deprivation in humans published in PubMed in the past 5 years, including 18 articles. We highlight evidence about the anatomical and behavioral aspects of neuroplasticity as different brain responses to different types of visual deprivation. We also focus on various very interesting aspects of the cross-modal functional reorganization of the visual and auditory cortex as an example of brain plasticity due to combined visual and auditory loss. Our study shows that central nervous system magnetic resonance imaging (MRI) advancements have allowed researchers to report previously elusive anatomical evidence. Patients with a known mechanism of IRD—examined with high magnetic field MRI and functional MRI—have been proven to be adequate models to explore neuroadaptations of the visual pathway due to bilateral, early, and late visual deprivation.

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Plastic reorganization of the topological asymmetry of hemispheric white matter networks induced by congenital visual experience deprivation

Jiao,

Wang,

Luo

et al. 2024

NeuroImage

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The influence of visual deprivation on the development of the thalamocortical network: Evidence from congenitally blind children and adults

Cited by 4 publications

References 127 publications

Cortico–subcortical spatiotemporal dynamics in Parkinson’s disease can be modulated by transcranial alternating current stimulation

Cortico–subcortical spatiotemporal dynamics in Parkinson’s disease can be modulated by transcranial alternating current stimulation

Anatomical and Functional Impacts of Congenital Bilateral Visual Deprivation on the Visual Pathway—A Comprehensive Review

Plastic reorganization of the topological asymmetry of hemispheric white matter networks induced by congenital visual experience deprivation

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