The influence of visual and auditory receptive field organization on multisensory integration in the superior colliculus

Kadunce, Daniel C.; Vaughan, J. William; Wallace, Mark T.; Stein, Barry E.

doi:10.1007/s00221-002-1069-x

Cited by 37 publications

(63 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is shown quite clearly in Figure 4 B, which plots the averages of the enhancement index as a function of the sum of the responses to the component stimuli (a composite index of effectiveness) for both the control (open symbols) and deactivation (filled symbols) conditions. In agreement with previous studies (Meredith and Stein, 1986a;Stein and Meredith, 1993;Wallace and Stein, 1997;Jiang et al, 2001;Kadunce et al, 2001;Perrault et al, 2003;Stanford et al, 2005;Alvarado et al, 2007), enhancement values declined steeply with increasing stimulus effectiveness in the control condition. During deactivation, mean enhancement was uniformly low across all response levels, with no inverse effectiveness in evidence (Mann-Whitney U ϭ 3564; Z ϭ Ϫ5.94; p Ͻ 0.0001) Thus, the effect of cortical deactivation declined in direct proportion to the decline in multisensory enhancement.…”

Section: Population Profiles Effect Of Cortical Deactivation On Enhansupporting

confidence: 92%

Cortex Mediates Multisensory But Not Unisensory Integration in Superior Colliculus

Alvarado¹,

Stanford²,

Vaughan³

et al. 2007

J. Neurosci.

105

View full text Add to dashboard Cite

Converging cortical influences from the anterior ectosylvian sulcus and the rostral lateral suprasylvian sulcus were shown to have a multisensory-specific role in the integration of sensory information in superior colliculus (SC) neurons. These observations were based on changes induced by cryogenic deactivation of these cortico-SC projections. Thus, although the results indicated that they played a critical role in integrating SC responses to stimuli derived from different senses (i.e., visual-auditory), they played no role in synthesizing its responses to stimuli derived from within the same sense (visual-visual). This was evident even in the same multisensory neurons. The results suggest that very different neural circuits have evolved to code combinations of cross-modal and within-modal stimuli in the SC, and that the differences in multisensory and unisensory integration are likely caused by differences in the configuration of each neuron's functional inputs rather than to any inherent differences among the neurons themselves. The specificity of these descending influences was also apparent in the very different ways in which they affected responses to the component cross-modal stimuli and their actual integration. Furthermore, they appeared to target only multisensory neurons and not their unisensory neighbors.

show abstract

Section: Population Profiles Effect Of Cortical Deactivation On Enhansupporting

confidence: 92%

Cortex Mediates Multisensory But Not Unisensory Integration in Superior Colliculus

Alvarado¹,

Stanford²,

Vaughan³

et al. 2007

J. Neurosci.

105

View full text Add to dashboard Cite

show abstract

“…Support for this idea comes from the fact that smaller receptive field sizes have been found with HRTF-based stimulus presentations (Mrsic-Flogel et al, 2003). Smaller auditory receptive fields with sizes comparable with those observed for area VIP neurons as obtained in our present study have also been described in the CM (Recanzone et al, 2000) and the representation of frontal space in the superior colliculus (Kadunce et al, 2001).…”

Section: Auditory Receptive Fieldssupporting

confidence: 87%

“…The auditory RFs tended to be slightly larger than the visual ones, which is comparable with the findings of Kadunce et al (2001), who studied multimodal responses in the superior colliculus. On the other hand, this tendency could also be related to the fact that the spatial resolution of the auditory system is poorer than the one of the visual system (for review, see King, 1999;Shimojo and Shams, 2001).…”

Section: Auditory and Visual Responsessupporting

confidence: 87%

Multisensory Space Representations in the Macaque Ventral Intraparietal Area

Schlack¹,

Sterbing²,

Hartung³

et al. 2005

J. Neurosci.

298

235

View full text Add to dashboard Cite

Animals can use different sensory signals to localize objects in the environment. Depending on the situation, the brain either integrates information from multiple sensory sources or it chooses the modality conveying the most reliable information to direct behavior. This suggests that somehow, the brain has access to a modality-invariant representation of external space. Accordingly, neural structures encoding signals from more than one sensory modality are best suited for spatial information processing. In primates, the posterior parietal cortex (PPC) is a key structure for spatial representations. One substructure within human and macaque PPC is the ventral intraparietal area (VIP), known to represent visual, vestibular, and tactile signals. In the present study, we show for the first time that macaque area VIP neurons also respond to auditory stimulation. Interestingly, the strength of the responses to the acoustic stimuli greatly depended on the spatial location of the stimuli [i.e., most of the auditory responsive neurons had surprisingly small spatially restricted auditory receptive fields (RFs)].Given this finding, we compared the auditory RF locations with the respective visual RF locations of individual area VIP neurons. In the vast majority of neurons, the auditory and visual RFs largely overlapped. Additionally, neurons with well aligned visual and auditory receptive fields tended to encode multisensory space in a common reference frame. This suggests that area VIP constitutes a part of a neuronal circuit involved in the computation of a modality-invariant representation of external space.

show abstract

“…Again, although not systematically examined before, this feature is apparent in many of the prior examples of large response enhancements (Kadunce et al 2001;Meredith and Stein 1986a,b;Wallace et al 1993Wallace et al , 1996Wallace et al , 1998. Although spontaneous activity is believed to play a role in the development of afferent connectivity within the SC (GalliResta et al 1993;Itaya et al 1995), and likely is an important contributor to fixation aspects of SC motor function (Munoz and Guitton 1991), little is known about its role in sensory and multisensory processes.…”

Section: Introductionmentioning

confidence: 97%

“…Implantation and recording procedures were similar to those previously described (Kadunce et al 2001;Wallace et al 1993) and are detailed only briefly here. Visual-auditory multisensory neurons were the focus of this study and were isolated in the anesthetized animals using conventional single-unit electrophysiological techniques.…”

Section: Introductionmentioning

confidence: 99%

Neuron-Specific Response Characteristics Predict the Magnitude of Multisensory Integration

Perrault

Vaughan

Stein

et al. 2003

Journal of Neurophysiology

Self Cite

View full text Add to dashboard Cite

. Neuron-specific response characteristics predict the magnitude of multisensory integration. J Neurophysiol 90: 4022-4026, 2003. First published August 20, 2003 10.1152/jn.00494.2003. Multisensory neurons in the superior colliculus (SC) typically respond to combinations of stimuli from multiple modalities with enhancements and/or depressions in their activity. Although such changes in response have been shown to follow a predictive set of integrative principles, these principles fail to completely account for the full range of interactions seen throughout the SC population. In an effort to better define this variability, we sought to determine if there were additional features of the neuronal response profile that were predictive of the magnitude of the multisensory interaction. To do this, we recorded from 109 visualauditory SC neurons while systematically manipulating stimulus intensity. Along with the previously described roles of space, time, and stimulus effectiveness, two features of a neuron's response profile were found to offer predictive value as to the magnitude of the multisensory interaction: spontaneous activity and the level of sensory responsiveness. Multisensory neurons with little or no spontaneous activity and weak sensory responses had the capacity to exhibit large response enhancements. Conversely, neurons with modest spontaneous activity and robust sensory responses exhibited relatively small response enhancements. Together, these results provide a better view into multisensory integration, and suggest substantial heterogeneity in the integrative characteristics of the multisensory SC population.

show abstract

The influence of visual and auditory receptive field organization on multisensory integration in the superior colliculus

Abstract: Exp Brain Res (2001) 139:303-310Section "Methods", subheading "Stimulus delivery, data acquisition, and analysis": The formula should read as follows:The online version of the original article can be found at http://dx

Cited by 37 publications

References 0 publications

Cortex Mediates Multisensory But Not Unisensory Integration in Superior Colliculus

Cortex Mediates Multisensory But Not Unisensory Integration in Superior Colliculus

Multisensory Space Representations in the Macaque Ventral Intraparietal Area

Neuron-Specific Response Characteristics Predict the Magnitude of Multisensory Integration

Contact Info

Product

Resources

About