The Influence of Very Low Doses of Cisplatin on Tumor Cell Proliferation<i>In Vitro</i>and on Some Hematological and Enzymatic Parameters of Healthy Rats

Malarczyk, Elżbieta; Kandefer‐Szerszeń, Martyna; Jarosz-WilkoLazka, Anna

doi:10.1080/15401420390844500

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…The main molecular mechanism of cisplatin is myelotoxicity is due to its ability to bind with cellular DNA and render the cell incapable of replication [20]. Beside this, another mechanism of cisplatin is its ability to induce oxidative stress [21]. Reactive oxygen species are toxic to bone marrow cells and probably can trigger apoptosis and affect cell cycle, causing anemia and a decrease in leukocyte count [22].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Role of Bee Honey and Royal Jelly Against Cisplatin Induced Alteration in Hematological Parameters in Male Wister Albino Rat

Bhalchandra

Alqadhi

Ninawe

2018

Int J Pharm Pharm Sci

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Objective: This study aims to investigate the ameliorative role of dietary bee honey and royal jelly against cisplatin-induced alterations in hematological parameters in male wistar albino rat. Methods:Male wistar albino rats of same age and weight were randomly divided into four groups; G, I: control group which was given 0.9% saline, G: II: cisplatin (7 mg/kg/d) was injected intraperitoneally for 15 d, G, III bee honey with royal jelly (500 mg/kg/d of honey and 100 mg/kg/d of royal jelly) fed orally daily for 15 d, G, IV: cisplatin (7 mg/kg/d) was injected intraperitoneally and honey (500 mg/kg/d) and royal Jelly (100 mg/kg/d) fed orally daily for 15 d. The hematological parameters like total number of white blood cells (WBCs), red blood cells (RBCs), platelets, % of hemoglobin (Hb), and mean values of packed cell volume (PCV), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) were measured by using automated hematology system.

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Section: Discussionmentioning

confidence: 99%

Ameliorative Role of Bee Honey and Royal Jelly Against Cisplatin Induced Alteration in Hematological Parameters in Male Wister Albino Rat

Bhalchandra

Alqadhi

Ninawe

2018

Int J Pharm Pharm Sci

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“…Cisplatin alone treatment caused significant reduction in RBC counts with subsequent decline in Hb concentration and PCV which is a known side-effects induced by cisplatin in the hosts [47]. Therapeutic doses of cisplatin are evidently toxic to bone marrow cells and probably can trigger apoptosis and affect cell cycle causing an anemia and a decrease in WBC count [48]. In present study, treatment with the combination of rutin and cisplatin showed significant improvement in all the hematological values indicating its potential to reduce cisplatin-induced hematotoxicities (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

RJLBPCS

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Rutin, a naturally occurring flavonoid, possesses many pharmacological properties. Cisplatin is a well-known cancer chemotherapeutic drug. However, its full therapeutic efficacy is hindered due to development of various adverse side-effects in the host. The present study was focused on to evaluate rutincisplatin combination therapeutic efficacy and its protective role against cisplatin-induced hematotoxicity in ascites Dalton's lymphoma (DL) bearing mice. Ascites Dalton's lymphoma tumor-transplanted mice were treated with rutin or cisplatin alone and in the combination. The percentage increase in life span (ILS) of the hosts, cell viability, fluorescence-based apoptosis, glutathione and hematological parameters were determined under different treatment conditions. It was observed that cisplatin in combination with rutin has better therapeutic potential against murine ascites Dalton's lymphoma showing about 57 percent more ILS than cisplatin alone. The increased ILS observed during combination treatment could involve increased cytotoxicity and apoptosis in DL cells as compared to alone treatment. The combination treatment caused further decrease in reduced glutathione (GSH) level in tumor cells which could weaken its defensive ability and also assist in tumor cells death thereby increasing the host's survivability. Cisplatin treatment of the tumor-bearing mice caused a decrease in erythrocytes and leukocytes count and hemoglobin content which could lead to develop hematotoxicity in the hosts. However, the combination treatment showed a noteworthy improvement in all these hematological parameters suggesting a protective ability of rutin against cisplatininduced hematotoxicity.

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“…Antitumor drugs are known to suppress hematopoiesis. Cis-Pt caused hematotoxicity at both low (10 -8 -10 -12 g/ml per rat) [36] and high (4-16 mg/kg) concentrations [34,[37][38][39], with the development of anemic conditions both in intact and tumorbearing animals. In our study, Cis-Pt in a total dose of 3.75 mg/kg aggravated anemia in LLC-bearing mice as evidenced by the reduction of hemoglobin and erythrocyte levels by 21% and 20%, respectively, and lymphocytopenia (Table 2).…”

Section: The Survival Of Llc-bearing Mice Treated With Cis-pt and C 6...mentioning

confidence: 99%

Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma

et al. 2023

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Summary. Background: Cisplatin (Cis-Pt) is a widely used anticancer drug but its therapeutic efficiency is limited by hemato-, cardio-, hepato-, nephro- and neurotoxicity. Complexation of Cis-Pt with C60 fullerene nanoparticle will allow to enhance the antitumor activity of the drug and to reduce its side toxic effects. Aim: To estimate the antitumor effects of С60-Cis-Pt nanocomplex in Lewis lung carcinoma (LLC) and analyze hematological toxicity in tumor-bearing mice. Materials and Methods: Complexation of C60 fullerene and Cis-Pt molecule was studied by computer simulation. С60-Cis-Pt nanocomplex was i.p. injected to LLC-bearing mice in a total dose of 7.5 mg/kg (C60:Cis-Pt as 3.75:3.75 mg/kg). The survival of tumor-bearing mice and the relative reduction of tumor weight was recorded. Blood indices were determined using the Particle Counter PCE210 automatic hematology analyzer. Results: Computer simulation demonstrated the formation of С60-Cis-Pt nanocomplex in physiological medium and its stability due to the hydrophobic interactions. Treatment with C60-Cis-Pt nanocomplex increased survival time of LLC-bearing mice by 32%, normalized hemoglobin content (up to 100 g/l), erythrocyte and platelet count as compared to the untreated LLC-bearing mice. Tumor weight decreased by 35.5%; the mitotic index of tumor cells decreased by 78%, and apoptotic index increased by 75%. The revealed effects of the C60-Cis-Pt nanocomplex were more pronounced than the effects of Cis-Pt or C60 fullerene alone in equivalent dose. Conclusion: Treatment with C60-Cis-Pt nanocomplex prolonged the survival of LLC-bearing mice and reduced anemia in LLC-bearing mice.

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The Influence of Very Low Doses of Cisplatin on Tumor Cell ProliferationIn Vitroand on Some Hematological and Enzymatic Parameters of Healthy Rats

Cited by 8 publications

References 30 publications

Ameliorative Role of Bee Honey and Royal Jelly Against Cisplatin Induced Alteration in Hematological Parameters in Male Wister Albino Rat

Ameliorative Role of Bee Honey and Royal Jelly Against Cisplatin Induced Alteration in Hematological Parameters in Male Wister Albino Rat

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Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma

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