The high-temperature environment is a major factor that affects deep mining. Cooling has become a major expense, accounting for up to 25% of the total energy consumption of such mines. To address methods of cooling and the cooling cost, this paper studies the influence of the ventilation duct layout on the cooling effect. Six models were created in ICEM-CFD (3D modeling software), and the influence of cold airflow diffusion on the temperature of the mine environment was numerically simulated using ANSYS Fluent. Under the condition of the same ventilation volume, two models utilizing single pipe and double pipe scenarios were established, and six points were selected as the pipeline suspension position, forming six ventilation duct models. The cooling effect of each model was evaluated by analyzing the average temperature of the roadway section, the three-dimensional distribution of the roadway temperature and the velocity streamline of the whole roadway. The results show that the double-tube model has greater advantages than the single-tube model does, due to its superior local temperature, average temperature of the cross-section, range below 303 K, temperature uniformity and local wind speed. Among the models, model 4 (diameter of 0.5 m, 1.9 m away from the bottom of the roadway and 2.4 m away from the center of the circle) is the best pipeline layout scheme for comprehensive temperature values, roadway temperature uniformity and other factors. The average temperature is 299.3 K within 8 m from the mining face, which is 1.66 K lower than that of the single tube model. This configuration will increase the comfort of the mining environment and reduce cooling costs. These results can provide a reference for ventilation duct layouts of roadways in high temperature mines.