The influence of vacuum-assisted closure on inflammatory tissue reactions in the postoperative course of ankle fractures

Buttenschoen, Klaus; Fleischmann, W.; Haupt, Ulrich; Kinzl, L.; Buttenschoen, Daniela Carli

doi:10.1046/j.1460-9584.2001.00258.x

Cited by 39 publications

(23 citation statements)

References 25 publications

(58 reference statements)

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“…Of the 255 potentially relevant full articles, 23 (which described 20 trials) formed the primary focus. Three studies were excluded from further evaluation: in 1 RCT, incisional wounds after ankle surgery were studied, although such wounds can be sutured, 17 and in 2 studies, co-interventions (eg, use of bioartificial skin 18 or the technique of fracture fixation 19 ) were different between treatment groups. Of the remaining studies, 7 (reported in 8 articles) were RCTs [20][21][22][23][24][25][26][27] and 10 were non-RCTs.…”

Section: Literature Searchmentioning

confidence: 99%

Negative Pressure Wound Therapy

Gregor

Maegele²,

Sauerland³

et al. 2008

Arch Surg

163

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Section: Literature Searchmentioning

confidence: 99%

Negative Pressure Wound Therapy

Gregor

Maegele²,

Sauerland³

et al. 2008

Arch Surg

163

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“…11 The use of NPWT stimulates proliferation, production and remodeling of fibroblasts, extracellular matrix, as well as increases growth factors production. 11,16 The results of in vitro studies were confirmed by in vivo results. Scherer et al confirmed that cell proliferation expressed as a percentage of Ki67-positive nuclei was significantly greater in NPWT group compared to other groups in mice model.…”

Section: Mechanism Of Actionmentioning

confidence: 59%

Negative pressure wound therapy with instillation (NPWTi): Current status, recommendations and perspectives in the context of modern wound therapy.

Bobkiewicz

Studniarek

Drews

et al. 2016

NPWTJ

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REVIEWAbstract-Introduction of negative pressure wound therapy (NPWT) revolutionized the conception of wound healing. Currently, increasing number of studies confirmed the high efficiency of this therapy in many clinical scenarios. Moreover, some innovations have been introduced in recent years to improve the management of complex and chronic wounds. NPWT with instillation (NPWTi) combines traditional NPWT with application of topical irrigation solutions within the bed of the wound. Bioburden reduction, decreases time to wound closure, promotes granulation and tissue formation. Fewer operative visits are required when using NPWTi compared to standard NPWT. However, there are still questioned aspects of the NPWTi and thus its superiority over standard NPWT has not been fully indicated. Moreover, based on current studies no firm conclusions have been taken concerning the type of instilled solution preferably used, range of dwell-time phase, range of negative pressure and others. The main goal of the publication is to overview and summarize the current state of art concerning NPWTi. Moreover, mechanisms of action, review of the most commonly used instilled solutions are discussed and clinical evidence of NPWTi are described.

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“…However, this removal of exudate (which will include metallo-proteinases and other inflammatory mediators from the wound and oedema from the surrounding tissues encourages nutrient movement into the wound area even if blood flow is not increased. 22,23 Removal of fluid prevents a buildup of inflammatory mediators and encourages diffusion of further nutrients into the wound. This is all beneficial to the healing process especially in the case of chronic wounds where it has been hypothesised that an imbalance of metallo-proteinases can inhibit healing.…”

Section: Oedema Reduction and Exudate Managementmentioning

confidence: 99%

Outcome analysis of vacuum assisted closure application in open fractures of long bones

2017

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Background: We performed a prospective analysis to compare the efficacy of the vacuum assisted closure (VAC therapy) and conventional cotton gauze dressing of wounds.Methods: The study was conducted from July 2014 to June 2016 on patients admitted from emergency department or presenting in the outpatient department of the hospital. Necrotic tissues were debrided before applying VAC therapy. Dressings were changed every 3 or 4 days. For standard wound therapy, debridement followed by daily dressings was done. All patients were reconstructed with SSG/FLAP coverage after the granulation tissue was sufficient. Two groups of 10 each compared prospectively. Data were collected for age, sex, time needed for sufficient granulation tissue for coverage, length of hospital stay, no of debridements for VAC application and conventional gauze dressings.Results: Time needed to have a good granulation tissue sufficient for coverage, length of stay in hospital, and no of debridements were significantly less in VAC group. No major complication occurred that was directly attributable to treatment. Conclusions: Vacuum assisted wound therapy was found to facilitate the rapid formation of healthy granulation tissue on open musculoskeletal injuries, shortens hospital stay and minimize secondary soft tissue defect coverage procedures.

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The influence of vacuum-assisted closure on inflammatory tissue reactions in the postoperative course of ankle fractures

Cited by 39 publications

References 25 publications

Negative Pressure Wound Therapy

Negative Pressure Wound Therapy

Negative pressure wound therapy with instillation (NPWTi): Current status, recommendations and perspectives in the context of modern wound therapy.

Outcome analysis of vacuum assisted closure application in open fractures of long bones

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