1983
DOI: 10.1007/bf01772578
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The influence of urapidil, a new antihypertensive agent, on cerebral perfusion pressure in dogs with and without intracranial hypertension

Abstract: The influence of urapidil, an arylpiperazinederivate, on intracranial pressure (ICP), mean arterial pressure (MAP) and cerebral perfusion pressure (CPP) was investigated in dogs with (group II) and without (group I) intracranial hypertension. After i.v. administration of urapidil, intracranial pressure remained unchanged and cerebral perfusion pressure decreased to the same extent as mean arterial pressure (20%). As in neurosurgical patients, autoregulation of cerebral blood flow is often lost; a sudden increa… Show more

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Cited by 22 publications
(3 citation statements)
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“…Urapidil [34,35] is a peripheral a1 postsynaptic receptor antagonist as well as a central 5-hydroxytryptamine 1A receptor agonist. Its vasodilatory action is not accompanied by reflex tachycardia or any significant modification of the renin-angiotensin system.…”
Section: Urapidilmentioning
confidence: 99%
“…Urapidil [34,35] is a peripheral a1 postsynaptic receptor antagonist as well as a central 5-hydroxytryptamine 1A receptor agonist. Its vasodilatory action is not accompanied by reflex tachycardia or any significant modification of the renin-angiotensin system.…”
Section: Urapidilmentioning
confidence: 99%
“…Weitere Nebenwirkungen sind Stillstand der Wehentätigkeit sowie materne und neonatale Hypoglykämien. Als neuere Alternative gilt die Gabe von Urapidil, da es als al-Rezeptorblocker den SVR senkt ohne intrakranielle Druckanstiege zu verursachen (11,42). Initial wird ein Bolus von 5 -10 mg i.v.…”
Section: Diastolischer Blutdruckunclassified
“…1). Das gilt für die in der Anästh esie üblichen schn ell wirkend en Nitroprä pa rate Nitroprussid-Natrium (5, 6) un d Nitro glycerin (4, 6), aber auch für die Calcium -Antagonisten (3, 6,12 ,21), für Trimeta phan (27) und auch für die volatil en Anästhestika (13,(28)(29)(30). Hierbei macht au ch das in letzter Zeit in der Neuroanästhesie häufig ben ut zte Isoflur a n keine Ausna hm e, selbst wenn vor seiner Anwe ndung a us reiche nd sta rk hyperv enti liert wurde (13), so da ß es zu r Senk ung hype rtoner Blutdruckwerte bei Patienten mit reduzierter intracranieller Complia nce nicht zu em pfehlen ist (13,30).…”
Section: Disku Ssionunclassified