The Influence of Transforming Growth Factor β1 on the Expression of Genes Coding for Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases During Regeneration from Cerulein-Induced Pancreatitis

Role of Extracellular Matrix in Pancreatic Diseases

“…Inhibition of TGFß during regeneration from cerulein-induced pancreatitis in the rat did not completely abolish the formation of ECM, indicating the involvement of other factors [22]. In the same model, TGFß did not appear to significantly influence expression and activity of matrix metalloproteinases which participate in the removal of ECM during regeneration from pancreatitis [41] (see below). In addition, enhanced expression of a large number of growth factors and their receptors has been observed in both, pancreatic cancer and chronic pancreatitis (e.g.…”

“…For a more functional approach to the role of MMPs and their inhibitors in the development of pancreatic fibrosis we used the model of cerulein-induced pancreatitis in rats [41]. Surprisingly, increased expression during days 2-4 after induction of pancreatitis could only be demonstrated for MMP-2 and MMP-3.…”

Connective Tissue Growth Factor is Involved in Pancreatic Repair and Tissue Remodeling in Human and Rat Acute Necrotizing Pancreatitis

“…Although it is well documented from autopsy studies that pancreatic necrosis is replaced by granulation tissue and subsequently by connective tissue, the molecular mechanisms that mediate these changes are not well understood, mostly because of the lack of adequate human tissue material from these patients. [5][6][7]24,25 In the present report we evaluated the potential role of CTGF during pancreatic repair after ANP in humans. In addition, to better understand the human findings, the time course of CTGF mRNA expression was studied in relation to TGF-␤ in a standardized rat model of ANP.…”

Repetitive Acute Pancreatic Injury in the Mouse Induces Procollagen α1(I) Expression Colocalized to Pancreatic Stellate Cells

“…Active pancreatic matrix remodeling has been observed after acute injury in rat models when the expression of the matrix-degrading enzyme MMP-2 was transiently elevated (Elsä sser et al, 1989;Mü ller-Pillasch et al, 1997). The activity of MMP-2 was also increased in human chronic pancreatitis (Gress et al, 1994b), although the overall pancreatic collagenase activity was low in human chronic pancreatitis compared with that in normal people (Valderrama et al, 1998).…”