The influence of trait mindfulness on depression in multiple sclerosis: potential implications for treatment

Miller, Jennifer; Altaras, Caroline; Vissicchio, Nicholas A; Zemon, Vance; Portnoy, Jeffrey G; Gromisch, Elizabeth S.; Sloan, Jessica; Tyry, Tuula; Foley, Frederick W.

doi:10.1007/s11136-020-02567-6

Cited by 7 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This type of clinical intervention aims to increase psychological flexibility by working on aspects of acceptance and awareness. Similarly, mindfulness-based interventions may be also appropriate for pwMs, as trait mindfulness mediates the relationship between illness intrusiveness and depression in PwMS (Miller et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Mental Health in Multiple Sclerosis During the COVID-19 Outbreak: A Delicate Balance between Fear of Contagion and Resilience

Rosa

Scandurra

Chiodi

et al. 2022

J Clin Psychol Med Settings

View full text Add to dashboard Cite

The current study aimed at exploring the relationship between objective disability, illness perceptions, resilience, fear of COVID-19, and psychological distress (i.e., anxiety, depression, and stress) in people with multiple sclerosis (pwMS) during the second wave of the COVID-19 outbreak. A group of 122 pwMS recruited in an Italian university hospital took part in this cross-sectional monocentric study. Hierarchical multiple linear regression analyses were performed to assess the strength of the hypothesized associations. Results indicated that, differently from cognitive impairment, motor disability was positively associated with anxiety. However, accounting for subjective illness perception, such association was no longer significant. Moreover, accounting for both protective and risk factors in the models, even illness perception was no longer significant, highlighting the central role of resilience and fear of COVID-19 in explaining the negative emotional outcomes. Implications for clinical interventions and psychoeducational trainings are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Mental Health in Multiple Sclerosis During the COVID-19 Outbreak: A Delicate Balance between Fear of Contagion and Resilience

Rosa

Scandurra

Chiodi

et al. 2022

J Clin Psychol Med Settings

View full text Add to dashboard Cite

show abstract

“…Some previous studies that successfully addressed treatment mechanisms of MBI's in PwMS have used similarly small samples (e.g., [58], N = 40). However, other successful work that has focused on mediation analyses was based on considerably larger data bases (e.g., [34]), N = 755). Given this heterogeneity of sample sizes in the literature and considering the replication of positive findings in the cross-sectional analyses of the current work, it may be suggested to repeat this specific analysis of the current work using a larger sample.…”

Section: Mediating Role Of Depression In the Reduction Of Fatigue By ...mentioning

confidence: 99%

“…Recently, it has been suggested that the treatment mechanisms of MBIs in PwMS ought to be examined by obtaining information about the complex interrelations of commonly examined primary outcome variables (e.g., depression, fatigue, trait mindfulness) in context of mediation analyses [34,35]. It has been suggested that a reduction of fatigue through mindfulness training might be primarily attributable to a reduction of depressive symptoms [35].…”

Section: Introductionmentioning

confidence: 99%

Mindfulness training during brief periods of hospitalization in multiple sclerosis (MS): beneficial alterations in fatigue and the mediating role of depression

et al. 2021

View full text Add to dashboard Cite

Objectives Persons with MS (PwMS) are frequently affected by fatigue and depression. Mindfulness-based interventions may reduce these symptoms in PwMS and consequently their application has been extended to various settings. Only few efforts have been made to explore effects of short-term mindfulness training during brief periods of hospitalization. In the current study, the feasibility and potential effects of short-term mindfulness training on depression, fatigue, rumination and cognition were explored in PwMS in an acute-care hospital setting. Based on previous work, it was further examined whether the relation between trait mindfulness and fatigue prior to and following the intervention was mediated by depression and whether a mediation effect was also observable throughout the intervention. Methods A short-term mindfulness training protocol was developed, tailored to the requirements of the acute-care setting. Subsequently, 30 PwMS were recruited sequentially and received mindfulness training during the routine clinical process (median duration in hospital: eight days, number of sessions: four). Participants completed relevant self-report measures (depression, fatigue, rumination) and a neuropsychological assessment before and after training. Results Participants reported significantly increased trait mindfulness and decreased depression and fatigue following the intervention. Respective change scores were highly correlated so that increased trait mindfulness was associated with decreased symptoms. In the rumination domain, patients reported a tendency for an increased adaptive ability to engage in distractive behavior during arising negative mood. Other measures of trait rumination and cognition remained relatively stable. Results of the mediation analyses indicated that depression mediated the negative relationship between trait mindfulness and fatigue symptoms at pre and post assessments. With regards to the change scores, an association between mindfulness and cognitive fatigue ceased to be significant when depression was controlled, albeit in this case, the mediation effect did not reach significance. Conclusion Results of the current study indicate that short-term mindfulness training during brief periods of hospitalization may be beneficial for PwMS. They further complement previous work by identifying depression as a potential mediator of the antagonistic relationship between mindfulness and fatigue. Based on the current exploratory study, future trials are warranted to address this mechanism of mindfulness training in more detail.

show abstract

“…CBT has been found to have moderate effects on depression and stress reduction for PwMS (Hind et al, 2014; Reynard et al, 2014). Mindfulness has been associated with improvements in well‐being (Campbell & Pakenham, 2022; Han, 2021; Simpson et al, 2019), depression (Miller et al, 2020), anxiety, fatigue and sleep disturbances (Pagnini et al, 2019), emotion dysregulation (Schirda et al, 2020) and physical and cognitive fatigue (De la Torre et al, 2020). Assessments of the effectiveness of acceptance and commitment therapy (Pakenham et al, 2018), psychoeducation and supportive therapy and counselling (Topcu et al, 2020), or an the integration of these approaches (Molton et al, 2019), concludes that slight but significant improvements in quality of life, adjustment and coping with MS are evident.…”

Section: Introductionmentioning

confidence: 99%

The experience of psychological therapies for people with multiple sclerosis: A mixed‐methods study towards a patient‐centred approach to exploring processes of change

Fragkiadaki

Anagnostopoulos

Triliva

2023

Couns and Psychother Res

View full text Add to dashboard Cite

Psychological therapies are effective for managing multiple sclerosis (MS) symptoms such as depression, pain and fatigue. Cognitive behavioural therapy (CBT), mindfulness and other theory-led approaches have been applied and were found to have moderate effects. The present study adopts a patient-led approach to investigate people with MS' (PwMS) experiences of psychological therapies and the change processes they identify. In this naturalistic, mixed-methods design, semistructured interviews were conducted and three questionnaires were administered to 20 PwMS at two different times. Qualitative data collection and analysis followed the interpretative phenomenological analysis (IPA) guidelines, and quantitative data were analysed using paired t tests. Four superordinate themes described the participants' experiences of change as related to their psychological therapy: from despair to relief; from feeling their body as alien to becoming acquainted with an unpredictable new body; from helplessness to empowerment; and from punishment to forgiveness. Quantitative results showed that physical function and general health perception improved, and anxiety was significantly reduced. Despite seeking help from diverse psychological therapy modalities, the analysis revealed common themes that the participants found significant in their therapy stories. Following a patient-centred approach, the development of psychological therapies for PwMS should focus on their relationships, everyday lives, body perception, losses, shame and guilt. PwMS also need to be understood and acknowledged beyond their condition.

show abstract

The influence of trait mindfulness on depression in multiple sclerosis: potential implications for treatment

Cited by 7 publications

References 40 publications

Mental Health in Multiple Sclerosis During the COVID-19 Outbreak: A Delicate Balance between Fear of Contagion and Resilience

Mental Health in Multiple Sclerosis During the COVID-19 Outbreak: A Delicate Balance between Fear of Contagion and Resilience

Mindfulness training during brief periods of hospitalization in multiple sclerosis (MS): beneficial alterations in fatigue and the mediating role of depression

The experience of psychological therapies for people with multiple sclerosis: A mixed‐methods study towards a patient‐centred approach to exploring processes of change

Contact Info

Product

Resources

About