The Influence of Traffic-Related Air Pollution (TRAP) in Primary Schools and Residential Proximity to Traffic Sources on Histone H3 Level in Selected Malaysian Children

Suhaimi, Nur Faseeha; Jalaludin, Juliana; Bakar, Suhaili Abu

doi:10.3390/ijerph18157995

Cited by 8 publications

(5 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particulate matter (PM) is considered one of the most harmful components of ambient pollutants to humans [ 3 ]. Recent studies in the city of Kuala Lumpur, Malaysia demonstrated that PM pollution in this area is greatly contributed by vehicle emissions [ 4 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Environmental Polycyclic Aromatic Hydrocarbons (PAHs) Exposure on DNA Damage among School Children in Urban Traffic Area, Malaysia

Hisamuddin

Jalaludin

Bakar

et al. 2022

IJERPH

Self Cite

View full text Add to dashboard Cite

This study aimed to investigate the association between particulate PAHs exposure and DNA damage in Malaysian schoolchildren in heavy traffic (HT) and low traffic (LT) areas. PAH samples at eight schools were collected using a low volume sampler for 24 h and quantified using Gas Chromatography-Mass Spectrometry. Two hundred and twenty-eight buccal cells of children were assessed for DNA damage using Comet Assay. Monte-Carlo simulation was performed to determine incremental lifetime cancer risk (ILCR) and to check the uncertainty and sensitivity of the estimated risk. Total PAH concentrations in the schools in HT area were higher than LT area ranging from 4.4 to 5.76 ng m−3 and 1.36 to 3.79 ng m−3, respectively. The source diagnostic ratio showed that PAHs in the HT area is pyrogenic, mainly from diesel emission. The 95th percentile of the ILCR for children in HT and LT area were 2.80 × 10−7 and 1.43 × 10−7, respectively. The degree of DNA damage was significantly more severe in children in the HT group compared to LT group. This study shows that total indoor PAH exposure was the most significant factor that influenced the DNA damage among children. Further investigation of the relationship between PAH exposure and genomic integrity in children is required to shed additional light on potential health risks.

show abstract

Section: Introductionmentioning

confidence: 99%

The Influence of Environmental Polycyclic Aromatic Hydrocarbons (PAHs) Exposure on DNA Damage among School Children in Urban Traffic Area, Malaysia

Hisamuddin

Jalaludin

Bakar

et al. 2022

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…Importantly, PM potentially modifies histones with consequent alteration of cardiac structures. For example, previous clinical studies have shown that PM exposure induces histone 3 trimethylation (H3K4me3) in neonates, increased circulating levels of histone 3 (H3) in school-age children, and H3 trimethylation (H3K9me3, H3K27me3 and H3K36me3) and acetylation (H3K9ac) in adults ( Zheng et al, 2017 ; Vrijens et al, 2020 ; Suhaimi et al, 2021 ). Remarkably, some of these histone modifications are also associated with CVD.…”

Section: Pm-induced Dna and Histone Modifications Within The Context ...mentioning

confidence: 99%

Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health

Gavito-Covarrubias,

Ramírez-Díaz,

Guzmán-Linares

et al. 2024

Front. Genet.

View full text Add to dashboard Cite

Environmental pollution nowadays has not only a direct correlation with human health changes but a direct social impact. Epidemiological studies have evidenced the increased damage to human health on a daily basis because of damage to the ecological niche. Rapid urban growth and industrialized societies importantly compromise air quality, which can be assessed by a notable accumulation of air pollutants in both the gas and the particle phases. Of them, particulate matter (PM) represents a highly complex mixture of organic and inorganic compounds of the most variable size, composition, and origin. PM being one of the most complex environmental pollutants, its accumulation also varies in a temporal and spatial manner, which challenges current analytical techniques used to investigate PM interactions. Nevertheless, the characterization of the chemical composition of PM is a reliable indicator of the composition of the atmosphere, the quality of breathed air in urbanized societies, industrial zones and consequently gives support for pertinent measures to avoid serious health damage. Epigenomic damage is one of the most promising biological mechanisms of air pollution-derived carcinogenesis. Therefore, this review aims to highlight the implication of PM exposure in diverse molecular mechanisms driving human diseases by altered epigenetic regulation. The presented findings in the context of pan-organic cancer, fibrosis, neurodegeneration and metabolic diseases may provide valuable insights into the toxicity effects of PM components at the epigenomic level and may serve as biomarkers of early detection for novel targeted therapies.

show abstract

“…Also, information on respiratory symptoms was gathered by using a questionnaire, which was adapted from American Thoracic Society "ATS-DLD-78". The standardized questionnaire has been translated and proved to be valid in previous studies (22,23). In this study, we focused on four distinct respiratory symptoms that were treated as outcome variables: cough, phlegm, and wheeze for the last 3 months as well as chest tightness for the last 3 years.…”

Section: Assessment Of Respiratory Symptomsmentioning

confidence: 99%

Effects of Residential Proximity to Industrial Zone on Respiratory Symptoms among Residents in Parit Raja, Batu Pahat

Mohd Isa,

Md Som,

Jalaludin

et al. 2024

MJMHS

Self Cite

View full text Add to dashboard Cite

Introduction: The industrial park in the district of Parit Raja, Batu Pahat resulted in rapid growth of the town during the last 20 years and has been a reason of concern that this park also has contributed greatly to the problem of air pollution. The aim of this study was to evaluate the association between industrial air pollution and respiratory symptoms in adults living in the Parit Raja. Methods: A comparative cross-sectional study was undertaken among residents in the district of Parit Raja, Batu Pahat, Johor, Malaysia. A total of 110 residents aged between 19 and 65 years were randomly selected and information on personal characteristics and respiratory symptoms was obtained through a validated questionnaire. The prevalence of respiratory symptoms was compared between residents recruited from the areas situated about 5km radius of the industrial park (exposed) and >5km radius from the industrial park (comparative). Results: A total of 34.5% and 25.5% of adults from the exposed group reported experiencing coughing for the last 3 months and chest tightness for the last 3 years. The logistic regression models showed that symptoms of coughing was associated with the exposed group (aOR=6.34, 95% CI=2.08-19.35), male respondents (aOR=3.18, 95% CI=1.10-9.16) and who stay in Part Raja for more than 14 years (aOR=3.16, 95% CI=1.14-8.79). Conclusion: This study demonstrated that long-term air pollution exposures are consistently associated with respiratory symptoms in residents living in the proximity of industrial parks. Therefore, public health initiatives that aim to provide more conducive environment are needed, especially for residents living near industrial parks.

show abstract

The Influence of Traffic-Related Air Pollution (TRAP) in Primary Schools and Residential Proximity to Traffic Sources on Histone H3 Level in Selected Malaysian Children

Cited by 8 publications

References 73 publications

The Influence of Environmental Polycyclic Aromatic Hydrocarbons (PAHs) Exposure on DNA Damage among School Children in Urban Traffic Area, Malaysia

The Influence of Environmental Polycyclic Aromatic Hydrocarbons (PAHs) Exposure on DNA Damage among School Children in Urban Traffic Area, Malaysia

Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health

Effects of Residential Proximity to Industrial Zone on Respiratory Symptoms among Residents in Parit Raja, Batu Pahat

Contact Info

Product

Resources

About