The Influence of Titanium Dioxide Nanoparticles Incorporation into Soft Denture Lining Material on Candida albicans Adherence and Some Mechanical and Physical Properties

Ahmed, Amal Qasim; Ali, Mohammed

doi:10.22207/jpam.12.2.39

Cited by 13 publications

(10 citation statements)

References 28 publications

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“…Furthermore, the result of this study was agreed with Ahmed and Ali, 2018;Issa and Abdul-Fattah, 2015;Singh et al, 2018;Kreve et al, 2019, when they studied the effect of incorporation of nanoparticles to the denture soft lining materials and also agreed with other studies (Meran and Salem, 2020) when 3% of MgONPs was incorporated to a silicone maxillofacial silicone and found a significant inhibitory effect of these fillers against C. albicans.…”

Section: Discussionsupporting

confidence: 91%

Effect of Adding Magnesium Oxide Nanoparticles on the Antimicrobial Activity of a Denture Soft Liner

Al-Sammaraie

2020

Polytechnic j.

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Microbial growth and colonization are one of the disadvantages after the long-term use of denture soft liners. This study was aimed to evaluate the effect of the addition of magnesium oxide nanoparticles (MgONPs) on the antimicrobial activity of a denture soft liner. A total of 84 samples were prepared from a soft denture liner and divided into two groups, control group and test group to which 3% by weight of MgONPs were added, antimicrobial tests for Candida albicans, Staphylococcus aureus, and a mixture of the biofilm of both microorganisms were done, cell density count and adherence assay test was recorded before and after 6 months storage in distilled water. The results showed that the modified group performed a better antimicrobial activity compared to the control group, the addition of 3% of the nanofiller showed a significant reduction in the mean value of growth of both C. albicans, S. aureus, and the biofilm mixture (P < 0.05) before and after the storage period. In conclusion, the addition of 3% by weight of MgONPs to the denture soft liner significantly suppressed the growth of C. albicans, S. aureus up to 6 months.

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Section: Discussionsupporting

confidence: 91%

Effect of Adding Magnesium Oxide Nanoparticles on the Antimicrobial Activity of a Denture Soft Liner

Al-Sammaraie

2020

Polytechnic j.

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“…The particle map and EDX analysis showed evidence of the TiO 2 NPs. In the authors’ previous investigation, it was established by FTIR spectroscopy that a similar shape of absorption peaks was found for both the experimental and control samples, and this indicated no chemical reaction between TiO 2 NPs and PEMA [ 27 ]. Furthermore, the SEM images presented in Figure 6 demonstrate that TiO 2 NPs were fairly uniformly distributed with some areas of aggregation within the PEMA matrix.…”

Section: Resultsmentioning

confidence: 90%

“…However, special attention should be given to the fact that the addition of nanoparticles must not significantly affect other physical, mechanical, optical, or aesthetic properties. In a previous study, it was found that adding 2.0 wt.% TiO 2 NPs to PEMA soft liners resulted in a decrease in hardness, no change in shear bond strength, and an increase in the opacity of the liner material [ 27 ]. Similar results regarding the degradation of the mechanical and color properties of the PMMA denture base with the addition of TiO 2 NPs were also reported [ 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Antifungal Activity of a Soft Denture Liner Loaded with Titanium Oxide Nanoparticles (TiO2 NPs)

et al. 2023

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Aim: Soft denture lining materials are susceptible to be colonized by different microorganisms, especially by Candida albicans (C. albicans), causing denture-induced stomatitis. This study was designed to evaluate the effectiveness of incorporating titanium dioxide nanoparticles (TiO2 NPs) into a soft denture liner towards reducing microbial activity. Method: A total of 40 PEMA-TiO2 nanocomposites samples were fabricated by adding 0.0 wt.% (control), 1.0 wt.%, 1.5 wt.%, and 2 wt.% TiO2 NPs to a heat cured soft denture lining material (polyethyl methacrylate, PEMA). The prepared samples were divided into four groups (n = 10) according to the content of TiO2 NPs. The uniformity of TiO2 NPS distribution within the denture liner matrix was assessed using a Scanning Electron Microscope (SEM). The viable count of C. albicans was evaluated to test the antifungal resistance of the developed composite. Results: The SEM images showed fairly homogeneous dispersion, with patches of TiO2 NPs agglomeration within the PEMA matrix and an increasing concentration of NPs with higher NP content. The particle map and EDX analysis confirmed the evidence of the TiO2 NPs. The mean viable count results for the control (0.0 wt.%) and 1.0 wt.%, 1.5 wt.%, and 2 wt.% TiO2 groups were 139.80, 12.00, 6.20, and 1.00, respectively, with a significant difference from the control group (p < 0.05). The antifungal activity also increased with the increase in the concentration of TiO2 NPs. Conclusions: The addition of TiO2 NPs into a heat-cured soft denture liner provided antifungal activity as evidenced by the reduced colonization of C. albicans. The antimicrobial activity of the liner material increased with the increased concentration of TiO2 NPS.

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“…The specimens were withdrawn from the suspension and washed for 1 minute with phosphate-buffered saline (PBS) to eliminate yeast cells that had not been attached to the filter paper [22]. The adherent C. albicans cells on the soft liner specimens were fixed with methanol, stained with crystal violet for 60 seconds, rinsed with PBS for 30 s, dried with filter paper, and stored in sterile test tubes, and then inspected under an inverted light microscope [33]. The adherent C. albicans cells were counted in three standardized fields under an inverted light microscope.…”

Section: Preparation Of Sabouraud Dextrose Brothmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Background: Microorganism buildup is one of the most critical issues encountered with soft denture liner materials. The buildup of the fungus Candida albicans results in a disease known as denture-induced stomatitis. Therefore, creating a soft liner material with a medication delivery mechanism is required. This study aims to discover the best concentrations of lemongrass essential oil (LGEO) that are effective for inhibiting C. albicans growth for addition to the heat-cured soft denture liner materials. Materials and methods: For pilot study, three specimens were fabricated for each of the three concentrations (2.5, 5, and 7.5 vol%) of LGEO additives. For the main study, 40 specimens were prepared and divided into four groups (negative control, 2.5 vol.% LGEO additive, 5 vol.% LGEO additive, and positive control, which contained 1.4 wt.% nystatin additive) in accordance to the results of the pilot study. Each group consisted of 10 specimens. Results: In the pilot study, 2.5 and 5 vol.% LGEO were identified as the best two concentrations with good antifungal activity in the selected heat-cured soft-liner material. Meanwhile, the C. albicans adherence test showed that the number of C. albicans cells adhering to the soft liner specimens incorporating 2.5 and 5 vol.% LEGO additive (experimental groups) significantly decreased relative to that to specimens in the control negative and control positive groups (P < 0.05). The best concentration of LGEO additive that decreased the number of adherent C. albicans was 5 vol.%. Conclusion:The results of this work show that LGEO is a potent antifungal substance that may be effectively incorporated into soft liners to create materials that are effective against C. albicans fungi.

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The Influence of Titanium Dioxide Nanoparticles Incorporation into Soft Denture Lining Material on Candida albicans Adherence and Some Mechanical and Physical Properties

Cited by 13 publications

References 28 publications

Effect of Adding Magnesium Oxide Nanoparticles on the Antimicrobial Activity of a Denture Soft Liner

Effect of Adding Magnesium Oxide Nanoparticles on the Antimicrobial Activity of a Denture Soft Liner

Assessing the Antifungal Activity of a Soft Denture Liner Loaded with Titanium Oxide Nanoparticles (TiO2 NPs)

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