The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats

Badary, Osama A.; Abdel-Naim, Ashraf B.; Abdel-Wahab, Mohamed H.; Hamada, Farid M.A.

doi:10.1016/s0300-483x(99)00179-1

Cited by 178 publications

(108 citation statements)

References 24 publications

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“…It has been shown that TQ actively inhibits microsomal lipid peroxidation in rats with hyperlipidemic nephropathy induced by doxorubicin. 34 Elsherbiny and El-sherbiny have used male Sprague Dawley rats in their study and concluded that TQ could have a preventive effect on kidney damage caused by doxorubicin. 35 Ulu et al have shown in their study that TQ has a protective effect on renal tissue in rats with acute kidney injury induced by cisplatin.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

et al. 2015

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We aimed to investigate the protective role of thymoquinone (TQ) by targeting its antiapoptotic and antioxidant properties against kidney damage induced by arsenic in rats. We have used the 24 male Sprague-Dawley rats. Rats were divided into three groups. Physiological serum in 10 mL/kg dose as intragastric was given to the control group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) was given to the arsenic group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) and TQ (10 mg/kg, intragastric by gavage for 15 days) was given to the arsenic + TQ group. After 15 days, the animals' kidneys were taken theirs, then we have performed histological and apoptotic assessment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities and malondialdehyde (MDA) levels have examined as the oxidative stress parameters. We have determined the levels of arsenic. Increased renal injury and apoptotic cells have been detected in the arsenic group. Degenerative changes in the arsenic + TQ group were diminished. Although the MDA levels were augmented in the arsenic group, SOD, CAT and GSH-Px enzyme activities were lessened than the other groups. Our findings suggest that TQ may impede the oxidative stress, the cells have been damaged and also the generation of apoptotic cells arisen from arsenic. TQ plays a protective role against arsenic-induced toxicity in kidney and may potentially be used as a remedial agent.

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Section: Discussionmentioning

confidence: 99%

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

et al. 2015

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“…The active ingredients, i.e. thymoquinone, in few studies were reported to possess hypocholesterolemic potential [7,24]. The other possible justification of cholesterol reduction is owed to the slight anorexic effect of black cumin, as it reduces the appetite [25].…”

Section: Discussionmentioning

confidence: 99%

Supplementation of Powdered Black Cumin (Nigella sativa) Seeds Reduces the Risk of Hypercholesterolemia

Sultan

Butt

Ahmad³

et al. 2011

FFHD

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ABSTRACT:Background: Functional and nutraceutical foods are gaining immense popularity among the masses. Plants and their bioactive molecules are of prime importance. Although various plants from different geographical areas have been tested in the past, many horizons still need to be addressed. Black cumin (Nigella sativa L.) is one such example that is quite popular in South Asia and the Middle East.

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“…application increases the triglyceride levels, which is an indicator of hyperlipidemia, whereas oral application induces no changes in the triglyceride levels (Abu Khader, 2012). It was seen that TQ application on rats that had been subjected to experimentally induced hyperlipidemia decreased the blood cholesterol (Badary et al, 2000), total cholesterol and LDL (Ismail et al, 2010), TC, LDL-C (Nader et al, 2010) levels significantly, and decreased the HDL levels. It was concluded that this was a result of TQ's anti-atherosclerotic and antioxidant characteristics (Nader et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

The investigations of total antioxidant status and biochemical serum profile in thymoquinone-treated rats.

Kurt¹,

Dede²,

Ragbetli³

2015

Afr. J. Trad. Compl. Alt. Med.

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Background: This study was planned to determine the dosage and duration of thymoquinone (TQ) at which it demonstrates the optimum effect on the total antioxidant status (TAS) and the biochemical parameters in the blood serum. Materials and Methods: 48 male rats (Wistar-albino) weighing between 200-250 g were used as material. Group 1 (control) (TQ solution 5 mg/kg/day), Group 2 (15 mg/kg/day), Group 3 (30 mg/kg/day), Group 4 (45 mg/kg/day) and Group 5 (60 mg/kg/day) were designated, each containing 8 rats. Different doses of TQ (oral gavage) were administered for four weeks. Results: The TAS levels were determined to be considerably low statistically in all TQ-administered groups in comparison with the control group. It was determined that the serum biochemical parameters exerted a significant effect depending on the TQ doses. Conclusion: As a result, rats administered with TQ orally, at 60 mg/kg dosage, show that the liver and kidney function parameters in particular as different from normal. This brings us to the conclusion that at this dosage, there is reliable biochemical wise but future protective studies in which 30 mg/kg doses can be used safely is encouraged.

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The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats

Cited by 178 publications

References 24 publications

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

Supplementation of Powdered Black Cumin (Nigella sativa) Seeds Reduces the Risk of Hypercholesterolemia

The investigations of total antioxidant status and biochemical serum profile in thymoquinone-treated rats.

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