The influence of thymectomy on Germ-cells of the testis in mice

Jin, Zuanming; Ys, Zhang; Pomer, S.; Staehler, G.; Dh, Ren

doi:10.1007/bf02887914

Cited by 3 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, thymectomy increased lipoperoxidation with concomitant decreases in sperm quality, mitochondrial indices, and fertility; similar to the findings in mice (Jin et al ., ), spermatogenic index also decreased. The potential difference in immune cell composition in the testis and epididymis as a consequence of neonatal thymectomy and its effects on fertility deserve further investigations.…”

Section: Discussionmentioning

confidence: 82%

“…Some of the main causes of reproductive failure include environmental contaminants (Sun et al ., ), endocrine and neuroendocrine disruptors (Davidson & Bloch, ), vitamin and mineral deficiencies (Hurley & Doane, ), irradiation, hypoxia, physical injuries, drugs, and chemicals (Heywood & Wadsworth, ) as well as immune suppression (Jones, ; Bloom et al ., ). There has been an increasing interest in research involving the relationship between the immune system and reproductive function within the last 50 years (Nishizuka & Sakakura, , ; Rebar et al ., ; Farookhi et al ., ; Andersson, ; Bloom et al ., ; Jin et al ., ; Su et al ., ; Sharma et al ., ).…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Retracted: Is immunosuppression, induced by neonatal thymectomy, compatible with poor reproductive performance in adult male rats?

et al. 2017

View full text Add to dashboard Cite

With increasing knowledge that the immune system has a major impact on reproductive ‎health, the potential for cells arising in organs such as the thymus to alleviate oxidative stress ‎has been revealed. This study addresses the impact of neonatal thymectomy on male ‎reproductive function in pubertal and adult animals. Neonatal Sprague Dawley rats were allotted to four treatments consisting of fully thymectomized, partially thymectomized, intact, and sham-operated rats. Half of the rats in each treatment were sacrificed at 40 and the other half at 80 days of age. Testicular volume, ventral prostate and spleen weight, several sperm attributes (concentration, motility, livability, membrane integrity, sperm penetration into mucus, total antioxidant capacity, mitochondrial dehydrogenase activity), plasma superoxide dismutase, glutathione, and testosterone level as well as fertility decreased in thymectomized rats. Adrenal gland weight, sperm malondialdehyde level, indices of oxidative stress, sperm abnormality, testicular and sperm lipid peroxidation, protein carbonylation, and sperm reactive oxygen species generation increased in thymectomized rats. In thymectomized rats, the testes contained high levels of malondialdehyde but low levels of glutathione and ferric-reducing antioxidant power. Epididymal sperm reactive oxygen species, blood lipid peroxidation, and oxidative stress indices ‎‎in blood and spermatozoa were highest in fully thymectomized, intermediate ‎in partially thymectomized, and lowest in both pubertal and mature control rats. Blood levels of superoxide dismutase, lipid peroxidation indices, and ‎testosterone, and mitochondrial adenosine triphosphate and ‎dehydrogenase activities in epididymal spermatozoa were lowest in fully thymectomized, ‎intermediate in partially thymectomized, and highest in both pubertal and mature control rats.‎ The data indicated that increased oxidative stress and mitochondrial dysfunction might play a role in the mechanism of immunosuppression-induced testicular and sperm abnormalities.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 98%

Retracted: Is immunosuppression, induced by neonatal thymectomy, compatible with poor reproductive performance in adult male rats?

et al. 2017

View full text Add to dashboard Cite

show abstract

“…and function within the last 50 years (Nishizuka & Sakakura, 1970Rebar et al, 1981;Farookhi et al, 1988;Andersson, 1992;Bloom et al, 1992;Jin et al, 1995;Su et al, 2013;Sharma et al, 2014) [4][5][6][7][8][9][10][11][12]. Calzolari (1898) [13] have reported relationship between thymus and gonadal function; the experiment were made upon rabbits and guinea pigs and the results that conformed thymic enlargement occurs after gonadectomy in both sex.…”

mentioning

confidence: 99%

Histomorphometric Changes of Gonads in Male Guinea Pigs After Thymectomy

Murali¹,

Radhika²

2019

IJAR

View full text Add to dashboard Cite

The presence of the thymus gland during early life is essential for the normal development of immune system and as well as proper maturation of the hypothalamic -pituitary-gonadal axis. This study was to investigate the influence of thymus gland on male reproductive function. Aim:The aim of this study to investigate the effect of thymectomy on Morphometric changes of gonads in neonatal, prepubertal and pubertal thymectamized male guinea pigs.Material and Methods: In this study, a total of thirty male guinea pigs, thymectamized (n-6) and sham-operated (n-4) were studied in each group. The comparison of diameter of seminiferous tubules, luminal diameter and epithelial thickness in the thymectamized and sham operated male guinea pigs.Results: No Significant changes in the morphometry of seminiferous tubules of testis in thymectamized male guinea pigs compared to the sham-operated guinea pigs in all age groups. These results suggest that thymectomy had no detrimental effects on reproductive system in males at any intervals.

show abstract

Distribution of CD68‐, CD8‐, MHCI‐ and MHCII‐positive cells in the bull and ram testis and epididymis

Saruhan

Sağsöz

Akbalık

et al. 2018

Anat Histol Embryol

View full text Add to dashboard Cite

The mammalian testis possesses a special immunological environment because of its properties of remarkable immune privilege and effective local innate immunity. The testicular immune privilege protects immunogenic germ cells from systemic immune attack, and local innate immunity is important in preventing testicular microbial infections. Thus, this study aimed to immunohistochemically demonstrate the distribution and localization of CD68-, CD8-, MHCI- and MHCII-positive immune cells in the testes and epididymes. Negative immunoreactivity was detected in the seminiferous tubule epithelium and peritubular myoid cells of the testes upon staining in CD68, CD8 and MHC Class I. Positive CD68 immunoreaction was determined in the Sertoli cells and some Leydig cells. The detection of positive cells for CD8 clearly indicated the presence of lymphocytes. Furthermore, the staining with MHCI intensity was ascertained to vary from weak to moderate in the Sertoli and Leydig cells and connective tissue cells. MHCII-positive immunoreactivity was determined in myoid cells and Leydig cells in the interstitial area. The epithelium of the epididymis showed positive staining for CD68 and CD8, but the stroma displayed a rather weak staining. In the ram epididymis, neither intraepithelial nor interstitial positive reaction was observed for MHCI. In the epididymis, the basal cells displayed a stronger staining for MHCII. In conclusion, these cells not only contribute to local immunity through their direct effects on the quality of fertility in males, but also contribute either directly or indirectly to immune privilege by minimizing the development of both autoimmune reactions and potentially harmful risks.

show abstract

The influence of thymectomy on Germ-cells of the testis in mice

Cited by 3 publications

References 7 publications

Retracted: Is immunosuppression, induced by neonatal thymectomy, compatible with poor reproductive performance in adult male rats?

Retracted: Is immunosuppression, induced by neonatal thymectomy, compatible with poor reproductive performance in adult male rats?

Histomorphometric Changes of Gonads in Male Guinea Pigs After Thymectomy

Distribution of CD68‐, CD8‐, MHCI‐ and MHCII‐positive cells in the bull and ram testis and epididymis

Contact Info

Product

Resources

About