The Influence of the Type of Surgery on the Immediate Postoperative Results in Patients with Colorectal Cancer Operated in Emergency

Constantin, Georgiana Bianca; Firescu, Dorel; Voicu, Daniela; Ștefănescu, Bogdan Ioan; Mihailov, Raul; Socolovschi, Cristina; Panaitescu, Eugenia; Bîrlă, Rodica; Constantinoiu, S

doi:10.21614/chirurgia.115.2.227

Cited by 3 publications

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“…A longer hospital stay can also be attributed to the type of surgical approach used. In the analyzed service, most surgical procedures performed by RCC were of the resection with anastomosis type, being associated with a longer hospital stay compared to resection surgeries with ostomies (CONSTANTIN et al,2020).…”

Section: Resultsmentioning

confidence: 99%

Sociodemographic and Clinical Profile of Patients Undergoing Surgery for Colorectal Cancer in a Teaching Hospital

Antoniazzi¹,

Marçal²,

Cau³

et al. 2022

JHS

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Tracing the sociodemographic and clinical profile of patients undergoing colorectal surgery for cancer in a teaching hospital between 2010 and 2019, and estimating factors related to discharge and readmission. For this purpose, data will be collected, processed and analyzed from medical records of patients undergoing colorectal procedures at Hospital Santa Casa de Misericórdia de Vitória, which serves patients in the public and private network. The survey was approved by the CEP of EMESCAM with an opinion consubstantiated 4,167,383. Data from 350 patients were included. There was a higher proportion of patients aged 45 to 75 years (72.3%), female (53.7%), brown (71.1%), with a partner (53.7%), and attended by the SUS (88.9%). Most procedures were elective (78.3%), with a predominance of tumors in the ascending colon, followed by rectum and sigmoid colon. Most patients did not undergo ostomy. Approximately 46% of the individuals analyzed had metastasis, and 80% of the cases had free surgical margins. Comparing sociodemographic and clinical variables to the reason for discharge and postoperative readmission, it is suggested that unfavorable outcomes are associated with the nature of the surgery (p < 0.01) and marital status (p < 0.01). Conclusion: The present study suggests that there is a higher mortality in patients without a partner and undergoing emergency surgery, as well as a longer hospital stay in the latter group. This result is important in establishing public policies that improve screening and provide early treatment for this health problem, and generate data to improve hospital management.

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Section: Resultsmentioning

confidence: 99%

Sociodemographic and Clinical Profile of Patients Undergoing Surgery for Colorectal Cancer in a Teaching Hospital

Antoniazzi¹,

Marçal²,

Cau³

et al. 2022

JHS

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show abstract

“…In the literature, there is a growing interest in fi nding the threshold value of markers of systemic infl ammation above which the probability of death increases signifi cantly [41][42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

The Systemic Inflammation Marker NLR as a Prognostic Factor in Complicated Colorectal Cancer

Constantin¹,

Firescu²,

Mihailov³

et al. 2023

J Biomed Res Environ Sci

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Many recent scores based on the inflammatory response, such as Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Lymphocyte Monocyte Ratio (LMR) have been demonstrated to have a prognostic value in cancer patients. The ratio between neutrophils and lymphocytes is a very useful tool, most studies admitting its role as a prognostic marker in cancer. We made a retrospective study on 391 patients hospitalized and operated in emergency for complicated colorectal cancer in the Surgery II clinic of the "St. Ap. Andrei" from Galati, Romania, between 2008-2017. We demonstrated that the increased preoperative value of NLR was a negative prognostic factor for long-term survival in patients with complicated colorectal cancer (HR = 7.581, 95% CI = (6.358,9.039) (p = 0.000000)). The cut-off point is > 2.61, with sensitivity of 73.61 and specificity of 100.00. The mean survival time in patients with NLR < = 2.61 was 39,676, 95% CI = (37,189, 42,163) and in those with NLR > 2.61 it was 12,504, 95% CI = (11,747, 13,261), the difference between the survival time of patients with values above the cutoff and below the cutoff being statistically significant (p = 0.000000, Log-Rank).

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The pathological and immunohistochemical profile of tumor angiogenesis in perforated sigmoid carcinoma–Case report and short literature review

Mihailov,

Beznea,

Popazu

et al. 2024

ELECTRON J GEN MED

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Background: Little is known about the physiopathological factors or mechanisms that underlie tumor invasion of the serosa and lead to perforation in the peritoneal cavity. The aim of the work was to analyze the pathological and immunohistochemical factors of tumor neoangiogenesis which could influence tumor perforation in colorectal cancer. Results and discussions: 451 cases of complicated colorectal carcinomas were statistically analyzed, of which 19 cases were perforated sigmoid tumors. The immunohistochemical detection of mutant p53 proteins was the first molecular parameter examined in the context of the search for markers predicting the natural evolution mode in colorectal carcinomas. Conclusions: Both loss of p53 and overexpression of bcl-2 proteins confer immortalization on cancer cells by inhibiting the processes leading to apoptosis. The paper proposes a review of the specialized literature, but also the presentation of a clinical case.

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The Influence of the Type of Surgery on the Immediate Postoperative Results in Patients with Colorectal Cancer Operated in Emergency

Cited by 3 publications

References 0 publications

Sociodemographic and Clinical Profile of Patients Undergoing Surgery for Colorectal Cancer in a Teaching Hospital

Sociodemographic and Clinical Profile of Patients Undergoing Surgery for Colorectal Cancer in a Teaching Hospital

The Systemic Inflammation Marker NLR as a Prognostic Factor in Complicated Colorectal Cancer

The pathological and immunohistochemical profile of tumor angiogenesis in perforated sigmoid carcinoma–Case report and short literature review

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