2015
DOI: 10.1186/s12951-015-0111-7
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The influence of the size and aspect ratio of anisotropic, porous CaCO3 particles on their uptake by cells

Abstract: BackgroundRecent reports highlighting the role of particle geometry have suggested that anisotropy can affect the rate and the pathway of particle uptake by cells. Therefore, we investigate the internalization by cells of porous calcium carbonate particles with different shapes and anisotropies.ResultsWe report here on a new method of the synthesis of polyelectrolyte coated calcium carbonate particles whose geometry was controlled by varying the mixing speed and time, pH value of the reaction solution, and rat… Show more

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Cited by 132 publications
(148 citation statements)
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“…This is demonstrated in Fig. 4 (Parakhonskiy et al, 2015). In this study, colloids with different aspect ratio were investigated.…”
Section: The Importance Of Metrics In the Context Of Quantification Omentioning
confidence: 92%
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“…This is demonstrated in Fig. 4 (Parakhonskiy et al, 2015). In this study, colloids with different aspect ratio were investigated.…”
Section: The Importance Of Metrics In the Context Of Quantification Omentioning
confidence: 92%
“…First, upon immunostaining of endosomes/lysosomes, co-localization analysis provides information whether colloids are inside these intracellular vesicles and have been therefore internalized (Kastl et al, 2013;Parakhonskiy et al, 2015), cf. Fig.…”
Section: Distinguishing Internalized (Endocytosed) Versus Membraneattmentioning
confidence: 99%
See 1 more Smart Citation
“…[21] Recent findings have revealed that the geometry of the templates could affect their uptake into cells by phagocytosis. [22] Attachment of particles to the specific site of cells can be tuned not only via surface chemistry but also by changing the geometry of the particles even at the nanoscale. [23], [24], [25] Thus, future trends in particle assisted drug delivery are seen towards novel methods of synthesis and elaboration of anisotropic particles which in some cases may even resemble such natural entities as bacteria.…”
Section: Anisotropic Shapesmentioning
confidence: 99%
“…10,11 One of the earliest studies was by Chithrani et al on cetyltrimethylammonium bromide (CTAB) coated gold nanorods where a negative correlation between aspect ratio and cellular uptake was found. 12,13 However, recent research has highlighted the significance of multiple convoluted variables such as ligand cytotoxicity, 14 particokinetics, 15,16 colloidal stability 17 and nanoparticle volume, 18 among others. An appropriate example of this is the study of Qiu et al who found a similar result as Chithrani et al except that upon passivating the surface with polyelectrolytes the apparent shape-dependent uptake was diminished.…”
Section: Introductionmentioning
confidence: 99%