The influence of the phosphorus content on the bioactivity of sol–gel glass ceramics

Padilla, S.; Román, J.; Carenas, A; Vallet‐Regí, María

doi:10.1016/j.biomaterials.2004.02.054

Cited by 116 publications

(86 citation statements)

References 18 publications

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“…This finding is consistent with the results reported by other authors: The bioactive behavior of calcium silicate materials is affected by the presence of phosphate, [35 -37] which can increase the rate of formation of the apatite phase. [36,37] The study demonstrated that calcium silicate cements and calcium silicate P-doped cements may promote the precipitation of a 'bone-like' apatite layer on the external surface when exposed to a simulated body fluid solution.…”

Section: Discussionmentioning

confidence: 99%

Ageing of calcium silicate cements for endodontic use in simulated body fluids: a micro‐Raman study

Taddei

Tinti

Gandolfi

et al. 2009

J Raman Spectroscopy

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To evaluate bioactivity properties, a calcium silicate experimental cement (wTC) and a phosphate-doped wTC cement (wTC-TCP) were aged for different times (1-180 days) at 37 • C in two simulated body fluids, i.e. Dulbecco's phosphate buffered saline (DPBS) and Hank's balanced salt solution (HBSS). The cements were analyzed by micro-Raman spectroscopy to investigate the presence of calcium phosphate deposits and the composition changes as a function of the storage time (hydration of anhydrite/gypsum and formation of ettringite; hydration of belite/alite and formation of hydrated silicates). After 1 day of ageing in DPBS, the two cements already showed a different behavior: only the surface of wTC-TCP cement showed the band at 965 cm −1 , suggesting the formation of a detectably thick calcium phosphate deposit. The trend of the I 965 /I 990 Raman intensity ratio indicated the formation of a meanly thicker apatite deposit on the wTC-TCP cement until 90 days. After 60 days of ageing in DPBS, the thickness of the apatite deposit on wTC and wTC-TCP was about 200 and 500 µm, respectively, whereas at 180 days, the two cements did not appear significantly different (thickness of about 900 µm). The bioactivity of both cements in HBSS was less pronounced than in DPBS, according to the lower phosphate concentration of HBSS; at the same time, higher amounts of calcite were found on the surface of both cements. The wTC-TCP cement showed a higher bioactivity in this medium also; after 180 days, the thickness of the apatite deposit on wTC and wTC-TCP was <50 µm and about 100 µm, respectively.

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Section: Discussionmentioning

confidence: 99%

Ageing of calcium silicate cements for endodontic use in simulated body fluids: a micro‐Raman study

Taddei

Tinti

Gandolfi

et al. 2009

J Raman Spectroscopy

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“…9 Ca 2+ + 6 PO 4 3-→ Ca 9 (PO 4 ) 6 (1) As the solubility of CaSO 4 ·2H 2 O is higher than that of HA, the concentration of Ca 2+ promoted reaction (2), which increased the Ca/P molar ratio of HA. At higher pH values reaction (3) was suppressed.…”

Section: +mentioning

confidence: 99%

Synthesis, Characterization, and In Vitro Bioactivity of Sol‐Gel‐Derived Zn, Mg, and Zn‐Mg Co‐Doped Bioactive Glasses

2010

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Bioactive glasses in the systems CaO-SiO 2 -P 2 O 5 -ZnO, CaO-SiO 2 -P 2 O 5 -MgO, and CaO-SiO 2 -P 2 O 5 -MgO-ZnO were prepared and characterized. Bioactive glass powders were produced by the sol-gel method. The prepared bioactive glass powders were immersed in a simulated body fluid (SBF) for periods of up to 28 days at 310 K to investigate the bioactivity of the produced samples. Inductively coupled plasma (ICP) and ultraviolet (UV) spectroscopic techniques were used to detect changes in the SBF composition. X-Ray diffraction (XRD) was utilized to recognize and confirm the formation of a hydroxyapatite (HA) layer on the bioactive glass powders. Microstructural characterizations of the bioactive glass samples were investigated by scanning electron microscopy (SEM) techniques. Density, porosity, and surface area values of bioactive glass powders were also determined in order to characterize the textural properties of the samples. The results revealed the growth of an HA layer on the surface of the bioactive glass samples. MgO in the glass sample increases the rate of formation of an HA layer while ZnO in the glass slows it down.

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“…Incorporation of collagen molecules in the HA layer and further interaction with other biomolecules and cells then lead to the formation of new tissue (Hench 1998). The HA formation mechanism was originally identified through the surface compositional profiles measured by Auger electron spectroscopy (Clark et al 1976), and fully confirmed by a large number of subsequent investigations with different analytical techniques, ranging from vibrational and X-ray photoelectron spectroscopies to characterize the dynamical changes in the surface of the sample exposed to a physiological solution (Ogino et al 1980;Peitl et al 2001;Cerruti et al 2005a), to optical emission spectroscopy techniques to analyse the composition of the contact solution at different times (Sepulveda et al 2002;Arcos et al 2003), to scanning and transmission electron microscopy to study the morphology and composition of the sample particles after immersion in body fluids (Kokubo 1990;Padilla et al 2005).…”

Section: Kmentioning

confidence: 99%

Structural models of bioactive glasses from molecular dynamics simulations

2009

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The bioactive mechanism, by which living tissues attach to and integrate with an artificial implant through stable chemical bonds, is at the core of many current medical applications of biomaterials, as well as of novel promising applications in tissue engineering. Having been employed in these applications for almost 40 years, soda-lime phosphosilicate glasses such as 45S5 represent today the paradigm of bioactive materials. Despite their strategical importance in the field, the relationship between the structure and the activity of a glass composition in a biological environment has not been studied in detail. This fundamental gap negatively affects further progress, for instance, to improve the chemical durability and tailor the biodegradability of these materials for specific applications. This paper reviews recent advances in computer modelling of bioactive glasses based on molecular dynamics simulations, which are starting to unveil key structural features of these materials, thus contributing to improve our fundamental understanding of how bioactive materials work.

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The influence of the phosphorus content on the bioactivity of sol–gel glass ceramics

Cited by 116 publications

References 18 publications

Ageing of calcium silicate cements for endodontic use in simulated body fluids: a micro‐Raman study

Ageing of calcium silicate cements for endodontic use in simulated body fluids: a micro‐Raman study

Synthesis, Characterization, and In Vitro Bioactivity of Sol‐Gel‐Derived Zn, Mg, and Zn‐Mg Co‐Doped Bioactive Glasses

Structural models of bioactive glasses from molecular dynamics simulations

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