The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells

Gu, Guangzhi; Gao, Xiaoling; Hu, Quanyin; Kang, Ting; Liu, Zhongyang; Jiang, Mengyin; Miao, Deyu; Song, Qing; Yao, Lei; Tu, Yifan; Pang, Zhiqing; Chen, Hongzhuan; Jiang, Xinguo; Chen, Jun

doi:10.1016/j.biomaterials.2013.03.036

Biomaterials

2013

DOI: 10.1016/j.biomaterials.2013.03.036

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The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells

Guangzhi Gu¹,

Xiaoling Gao²,

Quanyin Hu³

et al.

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Cited by 126 publications

(92 citation statements)

References 47 publications

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“…This approach was verified by using collagenase-coated NPs that produced a fourfold increase in the amount of 100 nm NPs delivered in MCTS. 73 NP diffusion in MCTS could also be improved by addition of cell-penetrating peptides on the NP surface such as RDG, 87,88 TAT or MPG. 64,65 It has been demonstrated that MPG-modified poly(d,l-lactic-co-glycolic acid) (PLGA) NPs exhibited a greater fluorescence intensity and a higher incorporation and diffusion in HeLa spheroids compared to unmodified PLGA NPs.…”

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confidence: 99%

“…65 Another possibility to achieve a higher NP penetration into MCTS was assessed by coadministration of the NP with the peptide iRGD, thus facilitating the NP extravasation and distribution. 88 The coadministration of a basic liposomal formulation of Taxol together with the iRGD peptide produced a threefold increase in drug accumulation and penetration into MCTS as compared with other liposomes or micelles especially designed to improve drug delivery in MCTS. 20 …”

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confidence: 99%

“…To estimate their distribution in spheroids, Oregon Green PTX was used. 20 More generally, fluorescent dyes such as rhodamine, 63,70,97 coumarin 87,88 or fluorescein isothiocyanate (FITC) are appropriate for this purpose. 95 Table 2 indicates that a great variety of NPs were designed to improve the anticancer drug delivery to tumors.…”

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confidence: 99%

“…On the basis of in vivo imaging in tumor-bearing mice, a strong parallel exists in the capacity of NPs to accumulate and to penetrate in cell spheroids as compared with tumor tissue. 65,66,87,88 For example, England et al 72 have shown that smaller citrate gold NPs exhibit enhancement of diffusion and accumulation in metastatic pancreatic adenocarcinoma spheroids (S2-VP10) compared to larger silica gold NPs. These results were also obtained in S2-VP10 orthotopic xenograft tumor and showed the predictive value of MCTS.…”

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confidence: 99%

“…The similarity between the evolution of spheroid volume and tumor growth after treatment constitutes a great advantage with respect to 2D cell models. 63,87,88,95 Predictive response of MCTS by mathematical models Nowadays, mathematical modeling is an invaluable tool for understanding the impact of cellular interactions on drug movement within MCTS. Indeed, the physical-chemical parameters of drug accumulation and distribution in tumor tissues can be determined by means of computational modeling.…”

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confidence: 99%

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Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Millard¹,

Yakavets²,

Zorin³

et al. 2017

IJN

108

107

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The increasing number of publications on the subject shows that nanomedicine is an attractive field for investigations aiming to considerably improve anticancer chemotherapy. Based on selective tumor targeting while sparing healthy tissue, carrier-mediated drug delivery has been expected to provide significant benefits to patients. However, despite reduced systemic toxicity, most nanodrugs approved for clinical use have been less effective than previously anticipated. The gap between experimental results and clinical outcomes demonstrates the necessity to perform comprehensive drug screening by using powerful preclinical models. In this context, in vitro three-dimensional models can provide key information on drug behavior inside the tumor tissue. The multicellular tumor spheroid (MCTS) model closely mimics a small avascular tumor with the presence of proliferative cells surrounding quiescent cells and a necrotic core. Oxygen, pH and nutrient gradients are similar to those of solid tumor. Furthermore, extracellular matrix (ECM) components and stromal cells can be embedded in the most sophisticated spheroid design. All these elements together with the physicochemical properties of nanoparticles (NPs) play a key role in drug transport, and therefore, the MCTS model is appropriate to assess the ability of NP to penetrate the tumor tissue. This review presents recent developments in MCTS models for a better comprehension of the interactions between NPs and tumor components that affect tumor drug delivery. MCTS is particularly suitable for the high-throughput screening of new nanodrugs.

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Millard¹,

Yakavets²,

Zorin³

et al. 2017

IJN

108

107

View full text Add to dashboard Cite

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Deeply Infiltrating iRGD‐Graphene Oxide for the Intensive Treatment of Metastatic Tumors through PTT‐Mediated Chemosensitization and Strengthened Integrin Targeting‐Based Antimigration

Wang

Zhou

et al. 2021

Adv Healthcare Materials

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A limited infiltration and the subsequent low effective drug concentration result in poor chemotherapeutic outcomes against tumors, and even further promote tumor resistance and metastatic. Herein, iRGD‐modified graphene oxide (GO) nanosheets (IPHG) are developed for the intensive treatment of metastatic tumors using focus‐specific penetrated delivery together with photothermal therapy‐mediated chemosensitization and photothermal therapy‐strengthened integrin targeting‐based antimigration. In vitro and in vivo data verified the mechanism of the tumor‐selective infiltration of IPHG is based on a rigid 2D structure‐associated advantage regarding hemodynamics and endothelial contact, followed by iRGD‐endowed transendothelial and intratumoral transport. Once IPHG‐DOX‐penetrated 4T1 tumors are exposed to near‐infrared irradiation, hyperthermia stress and photothermal therapy‐elevated effective drug concentrations result in chemosensitization and prominent tumor suppression. Meanwhile, the specific binding of iRGD to integrins and photothermal therapy leads to the synergistic perturbation of cytoskeleton remodeling and subsequent impairment of cell motility and metastasis. The tailored design of IPHG validates a promising paradigm for drug delivery to combat tumor resistance and metastasis resulting from poor target access for single chemotherapy.

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Smart Nanoparticle‐Based Platforms for Regulating Tumor Microenvironment and Cancer Immunotherapy

Cheng

Santos

2022

Adv Healthcare Materials

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Tumor development and metastasis are closely related to the tumor microenvironment (TME). Recently, several studies indicate that modulating TME can enhance cancer immunotherapy. Among various approaches to modulating TME, nanoparticles (NPs) with unique inherent advantages and smart modified characteristics are promising candidates in delivering drugs to cancer cells, amplifying the therapeutic effects, and leading to a cascade of immune responses. In this review, several smart NP-based platforms are briefly introduced, such as responsive NPs, targeting NPs, and the composition of TME, including dendritic cells, macrophages, fibroblasts, endothelial cells, myeloid-derived suppressor cells, and regulatory T cells. Moreover, the recent applications of smart NP-based platforms in regulating TME and cancer immunotherapy are briefly introduced. Last, the advantages and disadvantages of these smart NP-based platforms in potential clinical translation are discussed.

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The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells

Cited by 126 publications

References 47 publications

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening

Deeply Infiltrating iRGD‐Graphene Oxide for the Intensive Treatment of Metastatic Tumors through PTT‐Mediated Chemosensitization and Strengthened Integrin Targeting‐Based Antimigration

Smart Nanoparticle‐Based Platforms for Regulating Tumor Microenvironment and Cancer Immunotherapy

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