The influence of the microstructure on the hardness of sintered hydroxyapatite

Hoepfner, Timothy P.; Case, Eldon D.

doi:10.1016/s0272-8842(02)00220-1

Cited by 111 publications

(74 citation statements)

References 31 publications

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“…However, the previous study conducted by Harley et al demonstrated that the biomaterial with lower relative density improved penetration of NR6 fibroblasts into the scaffold variants. 44 The HV of bare HA was at about 3.371 GPa, which was close to that value reported by Hoepfner et al 45 The HV gradually increased as the doping of Fe 31 ions increased inside the SeHA lattice. This behavior can be explained the fact that the incorporation of Fe 31 ions decreased the particle size of the samples resulting in more compact and hard structures.…”

Section: Resultssupporting

confidence: 86%

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

et al. 2017

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Dual ions substituted hydroxyapatite (HA) received attention from scientists and researchers in the biomedical field owing to their excellent biological properties. This paper presents a novel biomaterial, which holds potential for bone tissue applications. Herein, we have successfully incorporated ferric (Fe 31 )/selenate (SeO 22 4 ) ions into the HA structure (Ca 10-x-y Fe y (PO 4 ) 6-x (SeO 4 ) x (OH) 2-x-y O y ) (Fe-SeHA) through a microwave refluxing process. The Fe-SeHA materials were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and field emission scanning electron microscopy (FESEM). XRD and FTIR analyses revealed that Fe-SeHA samples were phase pure at 9008C. FESEM images showed that formation of rod-like shaped particles was inhibited dramatically with increasing Fe 31 amount. The Vickers hardness (HV) test showed that hardness values increased with increasing Fe 31 concentrations. Optical spectra of Fe-SeHA materials contained broadband over (200-600) nm. In vitro degradation and bioactivity tests were conducted in simulated body fluid (SBF). The incorporation of Fe 31 /SeO 22 4 ions into the HA structure resulted in a remarkably higher degradation rate along with intense growth of apatite granules on the surface of the Fe-SeHA discs with Ca/P ratio of 1.35-1.47. In vitro protein adsorption assay was conducted in fetal bovine serum (FBS) and it was observed that the adsorption of serum proteins on Fe-SeHA samples significantly increased with increasing Fe 31 concentration. In vitro cytotoxicity tests were performed with human fetal osteoblast (hFOB)

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Section: Resultssupporting

confidence: 86%

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

et al. 2017

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“…16 There is a wide spread in the hardness data reported for sintered HA but it seems to range between 3.5 and 6.5 GPa for a fully dense ceramic. [36][37][38] The addition of glass increases the hardness but there is a larger dispersion in the measurements probably due to the larger grain size and the larger dispersion of the grain size distribution. After immersion in simulated body fluid the hardness of pure PLA and PLA/HA materials increase slightly.…”

Section: Microhardnessmentioning

confidence: 99%

Fabrication and in vitro characterization of three‐dimensional organic/inorganic scaffolds by robocasting

Russias

Saiz

Deville

et al. 2007

J Biomedical Materials Res

126

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A key issue for the fabrication of scaffolds for tissue engineering is the development of processing techniques flexible enough to produce materials with a wide spectrum of solubility (bioresorption rates) and mechanical properties matching those of calcified tissues. These techniques must also have the capability of generating adequate porosity to further serve as a framework for cell penetration, new bone formation, and subsequent remodeling. In this study we show how hybrid organic/inorganic scaffolds with controlled microstructures can be built using robotic assisted deposition at room temperature. Polylactide or polycaprolactone scaffolds with pore sizes ranging between 200-500 microm and hydroxyapatite contents up to 70 wt % were fabricated. Compressive tests revealed an anisotropic behavior of the scaffolds, strongly dependant on their chemical composition. The inclusion of an inorganic component increased their stiffness but they were not brittle and could be easily machined even for ceramic contents up to 70 wt %. The mechanical properties of hybrid scaffolds did not degrade significantly after 20 days in simulated body fluid. However, the stiffness of pure polylactide scaffolds increased drastically due to polymer densification. Scaffolds containing bioactive glasses were also printed. After 20 days in simulated body fluid they developed an apatite layer on their surface.

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“…[215]. Almost all metals take part in biomineralization, however, the best studied are the processes with participation of Si, Mg, Ca, Sr, Ba, and also Mn, Fe ions [216][217][218][219][220].…”

Section: Biomineralization and Bioconcentrationmentioning

confidence: 99%

Bionanocomposites Assembled by “From Bottom to Top” Method

Pomogailo

Джардималиева

2014

Nanostructured Materials Preparation via Condensation Ways

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Particles, which take part in different biological processes, have a special place in nanometer composites. Rich and variable biochemistry of proteins displays key importance of a nanometer phenomenon for a working mechanism of living organisms [1,2], and this provides a wide range of possibilities for development of new types of hybrid nanomaterials with constructible structures, functions and shapes [3][4][5].Integration of nanoparticles and biomolecules, each having unique properties, on the one hand, and being in the same nanometer scale (enzymes, antigens, and antibodies of typical sizes 2-20 nm like nanoparticles), on the other hand, as of two structurally compatible classes of materials, gives resultant new hybrid nanomaterials with synergetic properties and functions (Fig. 7.1).Interaction of nanoparticles with biopolymers (proteins, nucleic acids, polysaccharides) plays very important role in enzyme catalysis, biosorption, biohydrometallurgy, geobiotechnology, etc.). There is a great interest to nanomaterials, which can be used in biomedical and pharmaceutical applications due to their biocompatibility and biodegradation. At the same time bionanocomposites should meet some demands to plasticity of a matrix, they should have improved barrier, antimicrobial properties, ability to controlled release of bioactive substances such as antimicrobial agents, antioxidants, drugs, calcium compounds in biologically available form and their mixtures, etc. Biopolymers, such as natural and synthetic proteins, obtained by chemical methods or by genetic modification of microorganisms or plants, nucleic acids (including synthetic ones), biodegraded complex polyethers, such as polylactic acid, and its derivatives, oligo-hydroxyalkanoate, most often, polyhydroxybutyrate, their copolymers, biomedical materials, such as hydroxyapatites, are used. There is an interesting group of materials for this purpose including synthetic and natural (vegetable and animal) polysaccharides, such as cellulose and its derivatives, alginates, dextranes, acacia gum, chitosan, and any of its natural and synthetic derivatives, especially chitosan acetate, and proteins obtained from raw animal materials, as well as proteins from maize (especially zein) or soya, gluten derivatives, gelatin, casein, etc. Relatively widely used in

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The influence of the microstructure on the hardness of sintered hydroxyapatite

Cited by 111 publications

References 31 publications

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

Fabrication and in vitro characterization of three‐dimensional organic/inorganic scaffolds by robocasting

Bionanocomposites Assembled by “From Bottom to Top” Method

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The influence of the microstructure on the hardness of sintered hydroxyapatite

Cited by 111 publications

References 31 publications

Fe3+/− dual doped nano hydroxyapatite: A novel material for biomedical applications

Fe3+/− dual doped nano hydroxyapatite: A novel material for biomedical applications

Fabrication and in vitro characterization of three‐dimensional organic/inorganic scaffolds by robocasting

Bionanocomposites Assembled by “From Bottom to Top” Method

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Product

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Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications