The influence of the ketogenic diet on the elemental and biochemical compositions of the hippocampal formation

Various ketogenic diets can differently support brain resistance against experimentally evoked seizures and seizure-induced elemental anomalies of hippocampal formation

“…Such conclusion is also in agreement with our results. Our previous study showed that both KD1 and KD2 increased the level of ketone bodies in the hippocampal formation [21,22]. However, as it was shown in this paper only higher ketogenic ratio KD2 influenced the progress of pilocarpine evoked seizures and ameliorated the seizure behavior in animals.…”

“…Our previous studies carried out on different models of seizures showed that monitoring the hippocampal levels of Ca, Fe, Cu and Zn we can gain very important information about the pathogenesis and progress of epilepsy as well as about the neuroprotective and/or antiseizure action of particular drugs or diets [20][21][22][26][27][28][29][30]. Moreover, the existing evidence shows that the data on the elemental composition of this brain area can positively influence the research on the role of metals in the Alzheimer's disease or their use as contrast agents in magnetic resonance imaging [31][32][33].…”

“…The KDs with higher ketogenic ratios are usually more efficient in the seizure control but may be worse tolerate by the patients [19]. Our previous investigations showed, moreover, that elemental and biochemical changes occurring in the hippocampal formation after KD depended on its composition [20][21][22]. This suggests that also the mechanisms of anticonvulsive action of different KDs may not be the same.…”

Elemental changes in the hippocampal formation following two different formulas of ketogenic diet: an X-ray fluorescence microscopy study

“…Recently, it has been suggested that PUFAs, in conjunction with ketone bodies, may activate a lipid-sensitive class of K 2 P potassium channels and enhance the activity of the Na+/K+-ATPase (sodium pump) [ 6 , 53 ]. In this context, it is necessary to mention that both increased accumulation of ketone bodies and increased unsaturation level of lipids in the hippocampal formations were previously found for rats fed with KD1 and KD2, which was in detail described elsewhere [ 16 , 54 ].…”

“…In our previous experiment [ 16 ], we investigated effects of the KD on the elemental and biochemical compositions of the hippocampal formation. The diet had its ketogenic ratio set at 9:1.…”