The Influence of the Kallikrein-Trypsin Inactivator Trasylol on the Serum Cholinesterase

Chasapakis, G.; Augustaki, O.; Kekis, N.; Philippou, Prodromos; Moraitis, H.; A, Floras; Makkous, A.

doi:10.1093/bja/40.6.456

British Journal of Anaesthesia

1968

DOI: 10.1093/bja/40.6.456

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The Influence of the Kallikrein-Trypsin Inactivator Trasylol on the Serum Cholinesterase

G. Chasapakis¹,

O. Augustaki²,

N. Kekis³

et al.

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Cited by 4 publications

(2 citation statements)

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“…J. Anaesth. (1970), 42, 948), found that aprotinin inhibited plasma cholinesterase acivity by 5-16 per cent and not by about 25 per cent as we found in our study (Chasapakis et al, 1968).…”

supporting

confidence: 63%

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Influence of Aprotinin (Trasylol) on the Action of Suxamethonium

Doenicke

Gesing

Krumey

et al. 1970

British Journal of Anaesthesia

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“…J. Anaesth. (1970), 42, 948), found that aprotinin inhibited plasma cholinesterase acivity by 5-16 per cent and not by about 25 per cent as we found in our study (Chasapakis et al, 1968).…”

supporting

confidence: 63%

“…And we ended our second paper (Chasapakis et al, 1968) as follows: "Even in some patients from the present study (case Nos. 4, 6, 23, 28) in whom the enzyme, after the administration of Trasylol, was found to be 16, 20, 22, and 24.5 units/ml respectively, one should expect only a minor prolongation of the effects of suxamethonium."…”

mentioning

confidence: 99%

Influence of Aprotinin (Trasylol) on the Action of Suxamethonium

Doenicke

Gesing

Krumey

et al. 1970

British Journal of Anaesthesia

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Hypocalcaemia and Prolonged Curarization

Mckie

1969

British Journal of Anaesthesia

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New Approaches to the Treatment of Pemphigus

Grando

2004

Journal of Investigative Dermatology Symposium Proceedings

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In pemphigus vulgaris, treatment with systemic glucocorticosteroids is life saving; it may, however, cause severe side effects, including death. A patient with pemphigus vulgaris and myasthenia gravis was treated for approximately five years with the cholinomimetic Mestinon (pyridostigmine bromide), Imuran (azathioprine), and a topical corticosteroid gel before the need to introduce systemic glucocorticosteroids. Because activation of keratinocyte acetylcholine receptors also has been shown to abolish pemphigus IgG-induced acantholysis in cultured keratinocyte monolayers, a clinical trial of Mestinon was initiated in patients with active pemphigus vulgaris, pemphigus foliaceus, and paraneoplastic autoimmune multiorgan syndrome (also known as paraneoplastic pemphigus). First results indicate that nonsteroidal treatment of pemphigus is possible. Mestinon may be used to slow down progression of the disease and to treat mild cases with chronic lesions on limited areas. Stimulation of the keratinocyte- acetylcholine axis may lead to a therapeutic effect through any of the following mechanisms: (1) stimulating keratinocyte cell-to-cell attachment; (2) accelerating reepithelialization; and (3) competing with the disease-causing pemphigus antibodies, preventing them from attachment to keratinocytes. Glucocorticosteroids and various types of steroid-sparing drugs used to treat pemphigus exhibit cholinergic side effects, including effects on expression and function of keratinocyte adhesion molecules, that are very similar to those produced by the cholinomimetic drugs. Further elucidation of the mechanisms underlying therapeutic efficacy of antiacantholytics may shed light on the immunopharmacological mechanisms of pemphigus antibody-induced acantholysis.

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The Influence of the Kallikrein-Trypsin Inactivator Trasylol on the Serum Cholinesterase

Cited by 4 publications

References 0 publications

Influence of Aprotinin (Trasylol) on the Action of Suxamethonium

Influence of Aprotinin (Trasylol) on the Action of Suxamethonium

Hypocalcaemia and Prolonged Curarization

New Approaches to the Treatment of Pemphigus

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