The influence of the individual neuropsychiatric symptoms of people with Alzheimer disease on family caregiver distress—A longitudinal ALSOVA study

Hallikainen, Ilona; Koivisto, Anne M.; Välimäki, Tarja

doi:10.1002/gps.4911

Cited by 22 publications

(31 citation statements)

References 33 publications

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“…Among these eleven, the number of participants at baseline ranged from n = 41 to n = 2014. One study included 41 participants [15], three included between 100 and 200 participants [16][17][18], two studies included between 200 and 300 participants [19,20], and five included more than 300 participants [21][22][23][24][25]. The follow-up ranged from 3 to 36 months.…”

Section: General Study Characteristicsmentioning

confidence: 99%

“…The follow-up ranged from 3 to 36 months. One study [25] had a follow up of 3 months, one study [18] had a follow up of 6 months, five studies [15,16,[22][23][24] had a follow up between 12 and 24 months, and four studies [17,[19][20][21] had a follow up of more than 24 months. Of the included studies, eight studies [15,17,18,[21][22][23][24][25] defined the negative impact of caregiving as caregiver burden.…”

Section: General Study Characteristicsmentioning

confidence: 99%

“…Of these eights studies with burden as outcome, seven studies [15,17,[21][22][23][24][25] used the Zarit Burden Interview (ZBI), while Raccichini et al [18] used the Caregiver Burden Inventory (CBI). Three studies [16,19,20] had caregiver distress as the main outcome variable. Two studies used the General Health Questionnaire-12 (GHQ-12) [15,20] to operationalize the level of psychological distress in caregivers, while Svendsboe et al [19] used the Relative's Stress Scale (RSS).…”

Section: General Study Characteristicsmentioning

confidence: 99%

“…Three studies [16,19,20] had caregiver distress as the main outcome variable. Two studies used the General Health Questionnaire-12 (GHQ-12) [15,20] to operationalize the level of psychological distress in caregivers, while Svendsboe et al [19] used the Relative's Stress Scale (RSS). Of the eleven included studies, seven [15-18, 21, 22, 25] were assessed according to the AHRQ as Good quality and four [19,20,23,24] of Fair quality.…”

Section: General Study Characteristicsmentioning

confidence: 99%

“…While a variety of caregiver burden trajectories were reported, the majority (eight studies) found that it increased at follow-up (after 6 months [18], 12 months [23], 24 months [22], and 36 months [17,[19][20][21]24]). Only two studies reported that caregiver burden and/or distress remained stable at 12 months [15] and 18 months [16] of follow up.…”

Section: Trajectory Of Burdenmentioning

confidence: 99%

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The Trajectory of Caregiver Burden and Risk Factors in Dementia Progression: A Systematic Review

Kieboom

Snaphaan

Mark

et al. 2020

JAD

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Background: Caring for patients with dementia at home is often a long-term process, in which the independence of the patient declines, and more responsibility and supervision time is required from the informal caregiver. Objective: In order to minimize and reduce caregiver burden, it is important to explore its trajectory and the accompanying risk factors as dementia progresses; the objective of this systematic review. Methods: PRISMA guidelines were followed in this systematic review. Three databases, PubMed, PsycINFO, and EMbase, were systematically searched in November 2019 using specific keywords. Results: 1,506 hits emerged during the systematic search but only eleven articles actually met the inclusion criteria for this review. The trajectory of caregiver burden is highly variable and depends on multiple factors. Important risk factors included: patients’ behavioral and neuropsychiatric symptoms, and their decline in functioning in (I)ADL; the caregiver’s age, gender, and physical and mental health; and, within the dyads (patient/caregiver), cohabitation and kinship. Conclusion: There is no one-size-fits-all for predicting how caregiver burden will change over time, but specific factors (like being a spouse and increased behavioral impairment and decline in functional status in the patient) may heighten the risk. Other factors, not yet comprehensively included in the published studies, might also prove to be important risk factors. Future research in the field of reducing caregiver burden is recommended to integrate the patient, caregiver, and context characteristics in the trajectory of caregiver burden, and to assess more clearly the phase of the dementia progression and use of external resources.

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Section: General Study Characteristicsmentioning

confidence: 99%

Section: General Study Characteristicsmentioning

confidence: 99%

Section: General Study Characteristicsmentioning

confidence: 99%

Section: General Study Characteristicsmentioning

confidence: 99%

Section: Trajectory Of Burdenmentioning

confidence: 99%

See 3 more Smart Citations

The Trajectory of Caregiver Burden and Risk Factors in Dementia Progression: A Systematic Review

Kieboom

Snaphaan

Mark

et al. 2020

JAD

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Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018

Janus

Voorthuis

et al. 2022

Int J Geriat Psychiatry

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Objective Several European studies investigated the trends in psychotropic drug prescriptions (PDPs) among nursing home (NH) residents and reported a decline in antipsychotics prescriptions. Since the Dutch long‐term care system differs from other European systems (e.g. higher threshold for NH admission and trained elderly care physicians), this study explores the trends in PDPs in Dutch NH residents with dementia. Methods The study used data from nine studies, comprising two cross‐sectional studies, one cohort study, and six cluster‐randomized controlled trials, collected in Dutch NHs between 2003 and 2018. With multilevel logistic regression analysis, NHs as a random effect, we estimated the trends in PDPs overall and for five specific psychotropic drug groups (antipsychotics, antidepressants, anxiolytics, hypnotics, and anti‐dementia drugs), adjusting for confounders: age, gender, severity of dementia, severity of neuropsychiatric symptoms, and length of stay in NHs. Results The absolute prescription rate of antipsychotics was 37.5% in 2003 and decreased (OR = 0.947, 95% CI [0.926, 0.970]) every year. The absolute prescription rate of anti‐dementia drugs was 0.8% in 2003 and increased (OR = 1.162, 95% CI [1.105, 1.223]) per year. The absolute rate of overall PDPs declined from 62.7% in 2003 to 40.4% in 2018. Conclusions Among Dutch NH residents with dementia, the odds of antipsychotics prescriptions decreased by 5.3% per year while the odds of anti‐dementia drug prescriptions increased by 16.2%. There were no distinct trends in antidepressants, anxiolytics, and hypnotics prescriptions. However, overall PDPs were still high. The PDPs in NH residents remain an issue of concern.

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Effects of comprehensive intervention on life quality among the elderly with Alzheimer Disease and their caregivers based on mixed models

Yang

Cheng²,

Yu³

et al. 2021

Nursing Open

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Aims:We conducted a multi-sectoral comprehensive intervention for elderly Alzheimer Disease patients and their caregivers to improve their quality of life.Design: Randomized controlled trial. Methods:From June to June in 2019, 150 Alzheimer Disease patients were randomly selected from a nursing home in Zhejiang province of China, they were randomly divided into the intervention group and the control group. And they were given comprehensive and routine interventions respectively for six months. We used mixed models in our analyses to see how outcomes changed over time and how they were affected by the intervention, which could also solve the problems of missing values and data correlation. Results:After six months, compared with the control group, the communication ability, housework handling ability, self-care ability and life quality of the patients in the intervention group were improved, and the quality of life and caring ability of their caregivers were also significantly improved. Conclusion:The multi-sectoral collaborative care model proposed in this study integrated resources from several departments, effectively improved the quality of life of patients and their caregivers, and provided a way of care services for patients with Alzheimer Disease.

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The influence of the individual neuropsychiatric symptoms of people with Alzheimer disease on family caregiver distress—A longitudinal ALSOVA study

Abstract: Delusions, agitation, and sleep disturbances may cause distress to the FCs of persons with AD, especially if they live together. Clinicians should meet with FCs regularly and recognize those FCs at risk for a decline in psychosocial health.

Cited by 22 publications

References 33 publications

The Trajectory of Caregiver Burden and Risk Factors in Dementia Progression: A Systematic Review

The Trajectory of Caregiver Burden and Risk Factors in Dementia Progression: A Systematic Review

Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018

Effects of comprehensive intervention on life quality among the elderly with Alzheimer Disease and their caregivers based on mixed models

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