The influence of the human microbiome and probiotics on cardiovascular health

Ettinger, Grace; MacDonald, Kyle W.; Reid, Gregor; Burton, Jeremy P.

doi:10.4161/19490976.2014.983775

Cited by 148 publications

(117 citation statements)

References 121 publications

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“…Furthermore, a novel protein, p 75 has been isolated and purified from L. rhamnosus GG that leads to reduced ischemic injury, improved cardiac function and heart tissue infarction [139]. This was mediated through the enhanced expression of HSPs with p 75 pretreatment.…”

Section: Role In Cardiovascular Diseasementioning

confidence: 99%

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Singh¹,

Vishwakarma²,

Singhal³

2018

ABB

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The intricate "orchestered molecular conversation" between the host and gut microbiome is one of the most dynamic research areas in recent years. The rhythmic chemical cross talk in the form of bioactive metabolites and signalling molecules synthesized by gut microbiome plays a significant role for the modulation of human health in diversified ways. They are recognized as low molecular weight (LMW) molecules having versatile chemical attributes. They possess magnificent capability of interacting with surrounding environment and controlling the genes for various genetic, biochemical and physiological functions for maintaining the homeostasis that is now-a-days termed as "small molecules microbes originated (SMOM) homeostasis" in the host. These metabolic signatures have close structural and functional resemblance with small molecules synthesized by host eukaryotic cells and dietary components. Therefore, they may be considered as universalized metabolites contributing to the remarkable phenomenon of epigenetic regulation, cell to cell communication and stability of genome manifesting the overall growth and development of the host and known as "metabiotics". The wide panorama of utilization of probiotics is continuously expanding and conferring the major health benefits through metabiotic components are gaining tremendous momentum therefore recognized as "hidden soldiers" of the body. Therefore firstly, we outline the need and types of metabiotic molecules and depicting their role in human health. Then, we summarize their preventive and therapeutic avenues in various diseases and finally, we propose the current technological interventions, bottlenecks and future perspectives in this field that are implied for accelerating their comprehensive understanding and utilization at industrial scale.

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Section: Role In Cardiovascular Diseasementioning

confidence: 99%

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Singh¹,

Vishwakarma²,

Singhal³

2018

ABB

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“…The probiotics have been found to be effective for a large number of gut disorders and for improving/maintaining the oral and urogenital health (2)(3)(4). Other studies have indicated protective cardiovascular effects and promising effects in cancer, brain, obesity, allergy and atopic diseases, and in combatting diseases where dysbiosis has been observed (5)(6)(7)(8)(9). However, providing and maintaining the required minimum of viable probiotic cells to exert health effects (10 7 CFU/g at a point of delivery) is a great challenge, considering their sensitivity to processing, storage and administration.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus casei loaded Soy Protein-Alginate Microparticles prepared by Spray-Drying

Hadzieva

Mladenovska

Crcarevska

et al. 2017

Food Technol. Biotechnol.

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SummaryThis article presents a novel formulation for preparation of Lactobacillus casei 01 encapsulated in soy protein isolate and alginate microparticles using spray drying method. A response surface methodology was used to optimise the formulation and the central composite face-centered design was applied to study the effects of critical material attributes and process parameters on viability of the probiotic after microencapsulation and in simulated gastrointestinal conditions. Spherical microparticles were produced in high yield (64 %), narrow size distribution (d 50 =9.7 μm, span=0.47) and favourable mucoadhesive properties, with viability of the probiotic of 11.67, 10.05, 9.47 and 9.20 log CFU/g after microencapsulation, 3 h in simulated gastric and intestinal conditions and four-month cold storage, respectively. Fourier-transform infrared spectroscopy confirmed the probiotic stability after microencapsulation, while differential scanning calorimetry and thermogravimetry pointed to high thermal stability of the soy protein isolate-alginate microparticles with encapsulated probiotic. These favourable properties of the probiotic microparticles make them suitable for incorporation into functional food or pharmaceutical products.

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“…TMAO can also predict prognosis in patients with congestive heart failure, thus influencing clinical prognosis [13]. Interventions to change the microbiota have provided promising results [14] and been described as a potential new treatment target for cardio-metabolic disease. Such interventions should be based on the wider use of designed and tested functional food products as part of a healthy lifestyle in general.…”

Section: Biomarkers Of Diet-microbiota Patterns May Predict Future Camentioning

confidence: 99%

Microbiota patterns and risk of cardiometabolic disease — opportunities for intervention?

Nilsson

2016

Arterial Hypertension

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In every human being, there is a substantial proportion (1-2 kg) of total body weight constituted by the gut microbiota content in the gastro-intestinal system. Recent research findings, based on mapping of the microbiome, have stated that in healthy subjects, the gut microbiota richness and diversity is higher as compared to obese subjects or patients suffering from cardiometabolic disease, or even long-standing hypertension when a different and less rich pattern is seen (dysbiosis). Intervention with certain food constituents, e.g. Mediterranean diet or dairy products such as lactobacillae-containing yoghurt, holds promise that this could be of benefit for improved organ function, improved metabolism and lowering disease risk. Randomized, controlled intervention studies are needed to test the hypothesis that a reduction in dysbiosis induced by external dietary interventions could translate into health benefits.

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The influence of the human microbiome and probiotics on cardiovascular health

Cited by 148 publications

References 121 publications

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Lactobacillus casei loaded Soy Protein-Alginate Microparticles prepared by Spray-Drying

Microbiota patterns and risk of cardiometabolic disease — opportunities for intervention?

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