The Influence of the Foodstuffs Upon the Susceptibility of the Liver to Injury by Chloroform, and the Probable Mechanism of Their Action 12

Goldschmidt, Samuel; Vars, Harry M.; Ravdin, I. S.

doi:10.1172/jci101044

Cited by 98 publications

(12 citation statements)

References 2 publications

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“…It has been reported that high dietary fat enhances the deleterious effect of various hepatotoxins (7)(8)(9)(10)(11)(12) or may produce cirrhosis (19,20). The present studies indicate that certain fats such as lard and cod liver oil, when fed as 25 per cent of the diet, have some protective effect against liver damage caused by excess cystine, while butter does not.…”

Section: Discussionsupporting

confidence: 54%

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The Effect of Various Diets on the Liver Damage Caused by Excess Cystine

Earle

Victor

1942

Journal of Experimental Medicine

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1. The effect of 9 different diets on the liver lesions resulting from excess dietary cystine has been studied in 130 rats. 2. The incidence and severity of each of the following liver lesions were varied by changes in the composition of diets containing 5 or 10 per cent cystine: (a) Hemorrhage was least severe with low fat diets. (b) Necrosis was most severe with synthetic diets. (c) Cirrhosis was delayed by a diet high in lard, 20 per cent, and cod liver oil, 5 per cent, but not by a diet high in butter, 25 per cent. (d) Fatty infiltration was found consistently only with low protein, high fat diets. In other words, the pathogenesis of the liver lesion due to excess dietary cystine can be modified by diet. 3. In the presence of cystine as 5 per cent of a low protein, high fat diet, 1 per cent choline inhibited fatty infiltration but did not protect the liver against damage by cystine. 4. In these experiments there was no apparent correlation between fatty infiltration of the liver and the incidence or degree of cirrhosis.

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Section: Discussionsupporting

confidence: 54%

“…Most of the reported studies state that protein (8)(9)(10)(11)(12) and yeast (14) are protective against certain liver poisons. In the present experiments, liver damage resulting from 10 per cent cystine in low fat diets was not influenced by 5 or 40 per cent casein or by 5 or 20 per cent brewer's yeast.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Various Diets on the Liver Damage Caused by Excess Cystine

Earle

Victor

1942

Journal of Experimental Medicine

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“…The finding of liver damage in fatal cases of thyrotoxicosis (30 to 32) is in accord with the concept that there is a causal relationship between diminished hepatic stores and liver damage (33,34). A therapeutic agent capable of causing a rapid replacement of such losses should prove of considerable value in the preoperative management of patients with marked wasting.…”

Section: Serum Potassiummentioning

confidence: 54%

The Effect of Testosterone Compounds Upon the Nitrogen Balance and Creatine Excretion in Patients With Thyrotoxicosis 12

Kinsell¹,

Hertz²,

Reifenstein³

1944

J. Clin. Invest.

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“…It has also been shown that the feeding of excess fat (14) or of excess cystine (15) results in fibrotic changes in the liver. Other studies indicate a protective action against hepatotoxins by the feeding of yeast (16,17) or of high protein diets (18,19,20). It is possible that a balance of food factors may be essential to the integrity of a complex organ like the liver.…”

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confidence: 99%