The influence of the eutectic mixtures: salicylic acid – menthol and benzocaine – menthol on physical properties of the creams with fluconazole

Abstract

Flu cona zole, as the syn thetic an ti fun gal de riva tive of the tria zole, is used in treat ment of the sur face my co ses of the skin such as: tinea cor po ris, tinea cru ris, tinea fa ciei, tinea man num and tinea pe dis [2,15]. The fun gi cidal activ ity is the in hib it ing of 14-de meth y lase that is re spon si ble for the syn the sis of er gos terole-the compound re quired for the syn the sis of cell wall [4]. Men thol, a mono cyc lic monot er pene, is the main component of mint and pep per mint of Labi ate plants and has a long ap pli ca tion his tory in tra di tional medi cine. Com pared with other syn thet ics, men thol has lower toxic side ef fects and higher safety [11]. Men thol is also approved as a pene tra tion en han cer in the trans der mal trans port of sev eral drugs [12]. Sali cylic acid is phar ma ceu ti cal ac tive sub stance for topi cal use. It in hib its the se cre tion of se ba ceous and sweat glands. At low con cen tra tion it has kera to plas tic and in high doses kera to lytic ef fect. Sali cylic acid has a weak an ti mi cro bial ac tiv ity.

Thermal Behavior of the Nimesulide-Salicylic Acid Eutectic Mixtures Prepared by Mechanosynthesis and Recrystallization

“…Salicylic acid is also used as an exfoliant in cosmetic dermatology [25]. Salicylic acid does not show polymorphism and the presence of the -COOH group makes it a good coformer for obtaining eutectics or cocrystals [26][27][28]. Differential scanning calorimetry (DSC) is one of the most common analytical techniques used to characterize solids and implicitly the pharmaceutical ingredients both singular and in mixtures [29].…”

“…Many researchers have used this technique to determine the formation of eutectics and cocrystals between nimesulide and various coformers such as: nicotinamide [21], PVP [22], PEG [22,23], urea [23] and pyridine analogues [30]. To the best of our knowledge, only DSC data of pure nimesulide and, respectively, salicylic acid are found in the literature [24][25][26][27]. FTIR spectroscopy is widely used in conjunction with DSC and/or other techniques to characterize chemical structure modifications and molecular interactions in any physical state due to the high selectivity, low analysis costs and rapid sample preparation [21,22,[30][31][32].…”

“…Salicylic acid is also used as an exfoliant in cosmetic dermatology [25]. Salicylic acid does not show polymorphism and the presence of the -COOH group makes it a good coformer for obtaining eutectics or cocrystals [26][27][28].…”