It is important for industrial pig breeding to maintain a high level of animal productivity and preserve their health through the use of modern technologies and equipment for disinfection and treatment of premises, including in the presence of animals. The purpose of the research was to identify the most effective combinations of methods and modes of sanitary treatment of premises that contribute to the maximum manifestation of fattening and meat traits of pigs, preserving their health under the conditions of industrial pork production. The object of research was hybrid young pigs obtained from industrial crossbreeding of three breeds (Large White, Landrace, Pietren). It has been found as the result of the conducted investigations that the combination of the aerosol method of disinfection of livestock premises with additional aerosol air treatment during the fattening of young pigs contributes to the growth of its livability, improvement of fattening traits and increase in the efficiency of fattening. The daily consumption of animal feed during the fattening period does not depend on the method of disinfection of premises before they are put on fattening, but increases with the multiplicity of additional sanitary treatments, however, feed expenditures per 1 kg of increase have been reduced with wet disinfection from 3,10 to 2,83 kg, with aerosol disinfection from 3,10 to 2,59 kg. The biggest economic effectiveness of fattening has been noted when combining different methods of disinfection with the two-time regime of additional sanitary treatment of premises during the fattening period at the profitability level of 32,5 and 32,8 %.