The Influence of the Antecedent Diet upon Glucagon and Insulin Secretion

Müller, W.; Faloona, Gerald R.; Unger, Roger H

doi:10.1056/nejm197112232852603

Cited by 138 publications

(39 citation statements)

References 13 publications

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“…Glycerol's contribution to gluconeogenesis is not included in these estimates. Studies with H, [3][4][5][6][7][8][9][10][11][12][13][14] C]-lactate have shown that equilibrium of the hydrogen bound to carbon 6 with that in body water was 80±90 % complete, so that gluconeogenesis is underestimated by 10±20 % [13]. This corresponds to our results and implies that the 13C-glucose method is valid under the conditions of the experimental design of our study.…”

supporting

confidence: 87%

“…ly determines, firstly, blood glucose concentrations by affecting insulin and counterregulatory hormone secretion [7] and, secondly, the postprandial availability of substrates for hepatic glucose synthesis in the portal vein [8]. Protein-rich meals increase the concentration of glucogenic substrates, particularly amino acids in addition to glucose and lactate.…”

mentioning

confidence: 99%

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Effect of long-term dietary protein intake on glucose metabolism in humans

Linn¹,

Santosa²,

et al. 2000

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For different reasons interest in dietary protein intake has recently increased in diabetes research. Manipulation of protein ingestion has been used to slow down diabetic nephropathy [1]. Furthermore, epidemiological studies indicate that the quantity and quality of protein ingestion affects the expression of Type I (insulin-dependent) diabetes mellitus [2,3]. We have previously shown that a high protein diet accelerates the progression of the autoimmune loss of endogeneous insulin secretion in patients with Type I diabetes [4,5]. In general, high protein ingestion could be more detrimental in clinical situations with impaired glucose tolerance than is recognized; there is evidence that high protein intake promotes diabetes. Therefore, more knowledge is needed to decide in what way high dietary protein intake changes glucose metabolism in humans.The protein supplied by a meal is a major stimulator of insulin secretion [6]. Dietary protein potential- Diabetologia (2000) Results. Glucose-stimulated insulin secretion was increased in the high protein group (516 45 pmol/l vs 305 32, p = 0.012) due to reduced glucose threshold of the endocrine beta cells (4.2 0.5 mmol/l vs 4.9 0.3, p = 0.031). Endogeneous glucose output was increased by 12 % (p = 0.009) at 40 pmol/l plasma insulin in the high protein group, but not at higher insulin concentration whereas overall glucose disposal was reduced. Fasting plasma glucagon was 34 % increased in the high protein group (p = 0.038). Fractional gluconeogenesis was increased by 40 % in subjects receiving a high protein diet as determined by both methods. Conclusion/interpretation. High protein diet is accompanied by increased stimulation of glucagon and insulin within the endocrine pancreas, high glycogen turnover and stimulation of gluconeogenesis. [Diabetologia (2000

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supporting

confidence: 87%

mentioning

confidence: 99%

Effect of long-term dietary protein intake on glucose metabolism in humans

Linn¹,

Santosa²,

et al. 2000

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“…The HC104 was carefully drained off and 4 ml of 0.3 N KOH was added. Digestion was carried out in a 37°C water bath for I h. The samples were then neutralized with 10 N HC104 and acidified with 1 (Table I). Urinary sodium excretion in a subset of animals (n = 4 both groups) was not different between the 6% and 50% groups (283±21 vs. 290±62 jeq/24 h; P = NS).…”

Section: Methodsmentioning

confidence: 99%

“…Several hormonal alterations accompany variations in dietary protein intake including changes in glucagon, glucocorticoids, aldosterone, and prostaglandins (1)(2)(3)(4)(5)(6). Plasma renin activity also varies with the level of dietary protein, being higher on a high protein diet when examined in normal rats and humans, and in patients with a variety ofglomerular diseases (3-5, 7, 8).…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary protein on rat renin and angiotensinogen gene expression.

Rosenberg¹,

Chmielewski²,

Hostetter³

1990

J. Clin. Invest.

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“…The detection limit for the assay was 15 pg/ml. The results were also expressed as insulin/glucagon molar ratio which was calculated as suggested by Muller [21] using the formula [IRI (,u U! ml)/IRG (pg/ml)] x 23.33 = ratio.…”

Section: Hormone Studiesmentioning

confidence: 99%

Effect of cimetidine, ranitidine, famotidine and omeprazole on hepatocyte proliferation in vitro

Francavilla

Pañella

Polimeno

et al. 1989

Journal of Hepatology

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Recently reports have indicated that both cimetidine and ranitidine delay cell proliferation in rats following 7W/c partial hepatectomy and result in an increased mortality following this procedure. The present study was designed to determine whether three Hz blocking agents (cimetidine, ranitidine, famotidine) and a new, powerful antisecretory drug (omeprazole) specifically influence hepatocyte proliferation in primary culture. Hepatocytes were isolated from livers of normal male rats by the standard collagenase perfusion technique. Hepatic DNA synthesis and percent of labelled nuclei were determined after 48 h incubation. Hepatocytes in culture were incubated with the Hz blocking agents and omeprazole or with different concentrations of serum obtained from shamoperated or 70% hepatectomized rats treated or not with the same agents. Rats were injected intraperitoneally at 8:00 a.m. on two consecutive days. In hepatectomized rats, the first dose was injected at 1'\:00 a.m. immediately after surgery, the second, 24 h later. The serum of sham-operated or 70O/C hepatectomized rats that did not receive drugs served as control. No changes in DNA synthesis, percentage of labelled nuclei and transaminase were detected when the agents were added to the hepatocytes in culture at concentrations within the effective pharmacological dosage and 30 times higher. Similarly, no changes in these parameters were obtained when different concentrations of serum obtained from sham-operated rats treated with Hz blocking agents or omeprazole were added to the basal culture medium. However, a significant inhibition of DN A synthesis and of percentage of labelled nuclei was observed when hepatocytes were incubated in the presence of serum from 70o/r hepatectomized rats that had been treated with cimetidine or with ranitidine. The serum of 7fFX hepatectomized rats treated with famotidine and omeprazole had no effect on hepatocyte proliferation in vitro. No effect on transaminase was found in these conditions.

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The Influence of the Antecedent Diet upon Glucagon and Insulin Secretion

Cited by 138 publications

References 13 publications

Effect of long-term dietary protein intake on glucose metabolism in humans

Effect of long-term dietary protein intake on glucose metabolism in humans

Effect of dietary protein on rat renin and angiotensinogen gene expression.

Effect of cimetidine, ranitidine, famotidine and omeprazole on hepatocyte proliferation in vitro

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