The influence of tea catechins on immune function in the elderly: a single-arm, open-label clinical trial

Furushima, Daisuke; Iketani, Ryo; Nishimura, Takuma; Hirama, Yui; Onishi, Shintaro; Mori, Takuya; Ohno, Yuko; Yamada, Hiroshi

doi:10.1254/jpssuppl.wcp2018.0_po3-10-16

Cited by 1 publication

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“…Most notably, the authors highlight that the effects were more pronounced in participants who began the study with a lower NK activity (Furushima et al, 2018). According to these data, tea catechins can aid to normalize the cellular immune response of older adults.…”

Section: Human-derived Datamentioning

confidence: 88%

“…Results showed a potent immunostimulant action of the compounds, according to significantly increased NK cell activity (from 9.7 to 24.5%). Most notably, the authors highlight that the effects were more pronounced in participants who began the study with a lower NK activity (Furushima et al, 2018). According to these data, tea catechins can aid to normalize the cellular immune response of older adults.…”

Section: The Effects Of Phenolic Compounds On Systemic Inflammation A...mentioning

confidence: 99%

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Phenolic compounds can induce systemic and central immunomodulation, which result in a neuroprotective effect

Domínguez-Ávila

Salazar‐López

Montiel‐Herrera

et al. 2022

Journal of Food Biochemistry

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Inflammation may negatively impact health, particularly that of the central nervous system. Phenolic compounds are bioactive molecules present in fruits and vegetables with potential anti‐inflammatory effects. The purpose of the present work is to review the immunomodulatory bioactivities of phenolic compounds in the periphery and in the central nervous system. Results show that various types of phenolics are able to counter diet‐ or pathogen‐induced systemic inflammation (among others) in various models. In vitro data show significant effects of flavonoids and phenolic acids in particular; similar bioactivities were reported in vivo, when administering them as pure compounds or from fruit and vegetable extracts that contain them. In the central nervous system, phenolics counter chronic inflammation and aggressive acute inflammatory processes, such as ischemic events, when administered preemptively and even therapeutically. We therefore conclude that the immunomodulatory potential of phenolic compounds can maintain an adequate immune response; their regular consumption should therefore be prioritized in order to maintain health. Practical applications The immune response must be carefully regulated in order to avoid its deleterious effects. The present work highlights how phenolic compounds, dietary components ubiquitous in everyday diet, are able to maintain it within an adequate range. As humans are exposed to more proinflammatory stimuli (inadequate dietary pattern, mental stress, environmental pollution, chronic diseases, etc.), it becomes necessary to counter them, and consuming adequate amounts of foods that contain compounds with this ability is a rather simple strategy. Thus, the present work highlights how fruits and vegetables can help to maintain an adequate immune response that can preserve systemic health and that of the central nervous system. Furthermore, specific compounds contained in them can also be ideal candidates for additional in‐depth studies, which can potentially lead to the development of potent, targeted, and safe anti‐inflammatory molecules.

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Section: Human-derived Datamentioning

confidence: 88%

Section: The Effects Of Phenolic Compounds On Systemic Inflammation A...mentioning

confidence: 99%

Phenolic compounds can induce systemic and central immunomodulation, which result in a neuroprotective effect

Domínguez-Ávila

Salazar‐López

Montiel‐Herrera

et al. 2022

Journal of Food Biochemistry

View full text Add to dashboard Cite

show abstract

The influence of tea catechins on immune function in the elderly: a single-arm, open-label clinical trial

Cited by 1 publication

References 0 publications

Phenolic compounds can induce systemic and central immunomodulation, which result in a neuroprotective effect

Phenolic compounds can induce systemic and central immunomodulation, which result in a neuroprotective effect

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