The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats

Król, Ewelina; Okulicz, Monika; Kupsz, Justyna

doi:10.1007/s12011-020-02100-3

Cited by 4 publications

(5 citation statements)

References 57 publications

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“…However, 33% of the ingredients were fish meal and fish oil, which is matched with commercial diets for beluga. Improved growth in beluga-fed taurine-supplemented diets in this study can be due to improved mineral bioavailability as this amino acid is an organic acid, which enhance the bioavailability of minerals (Król et al, 2020).…”

Section: Ta B L Ementioning

confidence: 75%

“…However, 33% of the ingredients were fish meal and fish oil, which is matched with commercial diets for beluga. Improved growth in beluga‐fed taurine‐supplemented diets in this study can be due to improved mineral bioavailability as this amino acid is an organic acid, which enhance the bioavailability of minerals (Król et al, 2020). This was a preliminary study, and more research on other species is required to determine amino acid requirements for euryhaline species in different salinities.…”

Section: Discussionmentioning

confidence: 90%

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Should we farm beluga ( Huso huso ) in fresh water or brackish water?—The case study on taurine requirement

Slami

Bahrekazemi

Javadian

2022

Aquaculture Research

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This study was conducted to test the effect of taurine on growth performance, muscle composition, digestive enzyme activities, amino acid profiles and blood biochemistry of beluga (209.1 ± 23 g) in both fresh water (FW) and brackish water (BW: 15 ppt). Twelve experimental treatments with six taurine levels, for FW (Tau2.1, Tau4.3, Tau7.1, Tau12.3, Tau16.7 and Tau21.8) and BW (BwTau2.1, BwTau4.3, BwTau7.1, BwTau12.3, BwTau16.7 and BwTau21.8) were designed to feed and farm fish for 8 weeks. Generally, fish farmed in BW had better performance regarding growth. Regarding amino acid profile, fish‐fed moderate dosages of taurine (7.1 and 12.3 g/kg) had higher and lower taurine and serine in muscle, respectively. Beluga‐fed diets with 12.3‐ and 16.7‐g/kg taurine in FW and BW had the highest growth rate in line with the highest amylase and protease activities, alanine transaminase and aspartate transaminase; and lowest lactate dehydrogenase, triglyceride and cholesterol. The lipid‐lowering effect of taurine was observed. In conclusion, supplementation of beluga diets with 12.3‐ to 16.7‐g/kg taurine for farming in both FW and BW is required.

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Section: Ta B L Ementioning

confidence: 75%

Section: Discussionmentioning

confidence: 90%

Should we farm beluga ( Huso huso ) in fresh water or brackish water?—The case study on taurine requirement

Slami

Bahrekazemi

Javadian

2022

Aquaculture Research

View full text Add to dashboard Cite

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“…The increase in intracellular calcium concentration [Ca 2+ ] may activate adenylyl cyclase (AC), which then increases cyclic adenosine monophosphate (cAMP) cellular concentration, leading to protein kinase-A (PKA) catalytic subunit released from the regulatory subunit; PKA phosphorylates the calcium channels, and enhancing its voltage activity and sensitivity; finally, PKA together with calcium regulates insulin granule exocytosis. [23][24][25][26][27] When interfering with IR, taurine decreases blood glucose level via the following mechanisms; it decreases hepatic glucagon action and enhances hepatic insulin receptor-β/ protein kinase B (IRβ/Akt) activation, which favors glycolysis and glycogen biosynthesis, and suppresses glycogenolysis and gluconeogenesis, leading to reduction in hepatic glucose output. 23,28 Most of the above studies investigated the effects of taurine on animals and their results might not match necessarily with the clinical trials that carried on human beings.…”

Section: Discussionmentioning

confidence: 99%

Effect of Adding Taurine to Gabapentin on Toronto Clinical Neuropathy Score in Patient with Diabetic Neuropathy

Mohammad,

Mohammed,

Hlail

2023

IJDDT

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Diabetic neuropathy is a type of nerve damage that can occur in patients with diabetes mellitus. High blood glucose can injure nerves throughout the body. Diabetic neuropathy most often damages nerves in the legs and feet causing symptoms like pain and numbness. Taurine has been widely investigated regarding to its properties as a neuroprotective agent, antioxidant, anti-inflammatory in several neurodegenerative diseases. A sample consist of 40 participants enrolled randomly into two groups; group A, 20 patients treated with gabapentin capsules 300 mg once daily at night for 3 consecutive months, and group B, 20 patients treated with gabapentin capsules 300 mg once daily at night plus taurine 1 g thrice daily for 3 consecutive months. Adding taurine in combination with gabapentin significantly improves numbness, tingling, and temperature when compared with gabapentin alone. As well as, has a highly significant improving on ataxia. Taurine is better in improving insulin sensitivity due to lowering HbA1c level significantly, beside a medium degree in increasing insulin secretion; as evidenced by decreased fasting serum glucose, decreased HbA1c significantly, increased insulin level significantly, and increased C-peptide level. The conclusion of this study, adding taurine to patients with diabetic neuropathy has a significant improving effect on Toronto clinical neuropathy score by alleviating signs and symptoms, and improving insulin sensitivity.

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“…The biological activity of copper, iron, manganese and selenium is largely associated with the presence of unpaired electrons, which allows them to participate in oxidation-reduction reactions. Copper affects the activity of certain enzymes important for cellular respiration, protection against free radicals, melanin synthesis and the formation of connective tissue (Król et al, 2020). Changes in copper levels can also affect iron metabolism.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant system of the body of young Ukrainian beef cattle under the action of microelements

Mylostуva,

Farafonov,

Puzniak

et al. 2023

Regul. Mech. Biosyst.

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Active forms of oxygen are formed in the course of the organism's vital activity in biochemical reactions. These forms, when the pro/antioxidant balance is disturbed, trigger a cascade of lipid peroxidation, which can be the cause of the development of various pathological conditions. To prevent the negative influence of lipid peroxidation products in the body, a powerful antioxidant system is activated. This system consists of an enzymatic and a non-enzymatic link. An important aspect of the normal functioning of this system is the provision of the body with important trace elements. A number of minerals are included in the active center of antioxidant enzymes or have an effect on the reactions of non-enzymatic antioxidants. Research was conducted on fattening bulls of the Ukrainian meat breed. During the monitoring of microelements in feed, it was found that the vast majority of farm feed was deficient in copper, selenium and manganese and for this reason the animals consumed an insufficient amount of these minerals. These data were confirmed by the low content of these trace elements in blood serum. The addition of inorganic salts of microelements to the basic diet led to an increase in the concentration of copper, manganese and selenium in the blood serum by 20.5%, 37.3% and 23.9%. The study of the content of lipid peroxidation products showed that during the 30 days of the experiment, the level of lipid hydroperoxide increased by 25.5%, diene conjugates by 22.8%, and malonic dialdehyde by 22.0%. This indicates that against the background of increased age-related metabolism in the body of young animals, the oxidation-reduction reactions that are a predictor of the start of peroxidation processes increase. It was also noted that with a deficiency of certain trace elements, the activity of both the enzymatic and non-enzymatic links of the antioxidant system was reduced. Thus, in 30 days, the level of catalase, superoxide dismutase, and glutathione peroxidase decreased by 9.4%, 15.3%, and 13.0%, respectively. During this time, the content of tocopherol and ceruloplasmin decreased by 16.8% and 9.8%. Additives also had a positive effect on the activity of the antioxidant system by increasing its components. Additives of trace elements had different effects on the activity of antioxidant enzymes. The greatest effect on the level of catalase and superoxide dismutase was observed when copper salts were added, when the increase of these enzymes was noted by 1.11 and 1.23 times, respectively. Accordingly, the level of glutathione peroxidase was the highest in animals that received additional selenium – 1.21 times. The addition of copper also had the greatest biological effect on the important non-enzymatic component of antioxidant protection – ceruloplasmin. Its level increased by 1.24 times under the action of copper sulfate. The level of tocopherol was higher under the action of manganese, when its concentration was 1.11 times higher than the control. Against this background, there was a decrease in the products of lipid peroxidation: lipid hydroperoxides – 1.19 times under the action of selenium; diene conjugates – by 1.22 times and malonіс dialdehyde – by 1.11 times under the influence of copper and manganese compounds, respectively.

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The Influence of Taurine Supplementation on Serum and Tissular Fe, Zn and Cu Levels in Normal and Diet-Induced Insulin-Resistant Rats

Cited by 4 publications

References 57 publications

Should we farm beluga ( Huso huso ) in fresh water or brackish water?—The case study on taurine requirement

Should we farm beluga ( Huso huso ) in fresh water or brackish water?—The case study on taurine requirement

Effect of Adding Taurine to Gabapentin on Toronto Clinical Neuropathy Score in Patient with Diabetic Neuropathy

Antioxidant system of the body of young Ukrainian beef cattle under the action of microelements

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