The Influence of Systemic Hypertension on Intracranial Pressure and Edema Formation in Experimental Intracerebral Hemorrhage

Experimental intracerebral haemorrhage in normotensive and spontaneously hypertensive rats

“…However, Wallenfang etal. 15 found that ICP rises more in rats with acute hypertension than in normotensivc rats, with differences maintained at least for eight hours after the onset of the ICH. Differences in compliance could explain very early differences in ICP after experimental ICH, but to explain later changes other mechanisms must be involved.…”

“…About 75% of patients suffering from a ICH have arterial hypertension and half of them die during the first 24 hours after the beginning of the clinical symptoms. Some reports have pointed out a higher mortality and a poorer prognosis in hypertensive patients in comparison with patients with normal levels of blood pressure s' 10, 15,16. It seem that long term systemic hypertension changes the mechanical and metabolic brain responses to the development of vascular injury s'11 ' 15,16 Therefore in the present experimental study we have studied the local and haemodynamic changes produces in normal and genetically hypertensive rats in response to the development of an experimental intracerebral haemorrhage.…”