The influence of surgical trauma on experimental metastasis

Abstract

Influence of surgical trauma on experimental metastasis in healing wounds is investigated using a transplantable murine mammary carcinoma cell line, TA3Ha. Intravenous injection of 10(5), 10(6), and 2 x 10(6) TA3Ha cells into syngeneic Strain A mice led to liver or kidney tumor development in none of the 96, ten, and ten mice tested, respectively. In contrast, injection of 10(5) cells into mice immediately after hepatic wedge resection performed using milliwatt carbon dioxide laser and electrocautery resulted in tumor formation at the site of trauma in 21/37 (57%) and 25/52 (48%) mice, (P less than 0.001) respectively. Similar results were obtained in mice subjected to partial nephrectomy using the laser (nine of 18) and electrocautery (eight of 13). These results clearly demonstrate that surgical trauma renders a nonprivileged organ susceptible to experimental metastasis formation, and that at least in this model both laser and electrocautery have similar effects. Tumor cell injection 1, 7, and 10 days posthepatic surgery resulted in 36%, 20%, and 0% tumor formation, respectively, indicating that the earlier events in wound healing support tumor implantation and/or growth better than those later on. Frequency of tumor formation at sites of trauma in the peritoneum induced by scalpel blade, laser, and electrocautery were 28%, 50% and 82%, respectively. Peritoneal tumors were seen in 33% of the nonsurgical mice. Skin incisions induced with the three above probes had little influence on experimental metastasis formation. Thus the influence of trauma on tumor formation is not uniform in every organ.

A Case of Parastomal Hernia with Isolated Abdominal Wall Metastasis of Colorectal Cancer

“…The more evidence of promoting tumor cells in the healing tissues of the laparotomy incision or the anastomosis were explained with hematogenous implantation (15). It is considered much less likely as an explanation, because the liver and lungs receive all of the venous drainage from the colon prior to the distribution to the rest of the body, it seems unlikely that the tumor would spread hematogenously to the abdominal wall without pulmonary or hepatic involvement (16). In clinical trials, the incidence of this entity have been reported as 0.5-1%, but the autopsy studies have shown this ratio as 17% (4).…”

Gastric carcinoma metastasis to a knee with a newly inserted prosthesis: A case report

“…In connection with the knee arthoplasty, malignant cells circulating in the blood may have entered the damaged tissue in the operation area and found a suitable seeding ground there (Murthy et al 1989). …”

Biologic and therapeutic role of HER2 in cancer

“…The reasons for the early recurrences in HER2-positive tumors have been suggested to rest in events occurring at the time of surgery. Indeed, growth factors released during wound healing (Murthy et al, 1989;Sieweke and Bissell, 1994) have been shown to preferentially stimulate the growth of HER2-positive tumors (Tagliabue et al, 2001). These growth factors are more likely to have a stimulatory effect in patients with disseminated micrometastasis (node-positive patients) of an HER2-positive tumor, which might also explain the prognostic impact of HER2 according to nodal status.…”