The influence of surfactants on drug release from acrylic matrices

Buckton, Graham; Efentakis, M.; Alhmoud, Hassan A.; Rajan, Z.

doi:10.1016/0378-5173(91)90233-e

Cited by 17 publications

(4 citation statements)

References 3 publications

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“…The release rate of nystatin is less owing to its low solubility in water. The solubility of chlorhexidine in water is more than acyclovir and based on the solubility of the drugs in water one would expect the release rate of chlorhexidine to be more than that of acyclovir and the observed results may be explained due to other factors that influence the release of a drug from a polymer matrix such as their relative solubility in the polymer matrix, drug-polymer interactions and their relative diffusion through the channels in the polymer matrix [8].…”

Section: Effect Of Drug Loadingmentioning

confidence: 99%

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Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copolymer

Tallury¹,

K.²,

Thaw³

et al. 2007

Dental Materials

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Objectives-This study investigates the effects of surfactants and drug loading on the drug release rate from ethylene vinyl acetate (EVA) copolymer. The release rate of nystatin from EVA was studied with addition of non-ionic surfactants Tween 60 and Cremophor RH 40. In addition, the effect of increasing drug load on the release rates of nystatin, chlorhexidine diacetate and acyclovir is also presented.Method-Polymer casting solutions were prepared by stirring EVA copolymer and nystatin (2.5 wt %) in dichloromethane. Nystatin and surfactants were added in ratios of (1:1), (1:2) and (1:3). Drug loading was studied with 2.5, 5.0, 7.5, and 10.0% wt. proportions of nystatin, chlorhexidine diacetate and acyclovir incorporated into a separate polymer. Three drug loaded polymer square films (3cm × 3cm × 0.08 cm) were cut from dry films to follow the kinetics of drug release at 37°C. 10 ml of either distilled water or PBS was used as the extracting medium that was replaced daily. PBS was used for nystatin release with addition of surfactants and water was used for the study on drug loading and surfactant release. The rate of drug release was measured by UVspectrophotometer. The amount of surfactant released was determined by HPLC.Results-The release of nystatin was low in PBS and its release rate increased with the addition of surfactants. Also, increasing surfactant concentrations resulted in increased drug release rates. The release rates of chlorhexidine diacetate (p<0.0001), acyclovir (p<0.0003) and nystatin (p<0.0017) linearly increased with increasing drug loads. The amount of surfactants released was above the CMC.Significance-This study demonstrates that the three therapeutic agents show a sustained rate of drug release from EVA copolymer over extended periods of time. Nystatin release in PBS is low owing to its poor solubility. Its release rate is enhanced by addition of surfactants and increasing the drug load as well.

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Section: Effect Of Drug Loadingmentioning

confidence: 99%

“…The addition of surfactants promoted a far higher release of nystatin. There are other reports that have demonstrated an increase in drug release due to the addition of surfactants [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copolymer

Tallury¹,

K.²,

Thaw³

et al. 2007

Dental Materials

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“…The impacts of surfactant on the medication discharge rate have been broadly examined. Large numbers of the researchers worried about the surfactant impacts on discharge rate from various matrices especially from the hydrophilic polymers 53,54 , hydrophobic polymer 55 , and hydrophilic-hydrophobic polymers 56 . In an examination of the impact of stretching on surfactant properties of sulfosuccinates, it was accounted for that if the micelles are little enough the materials are as yet thought to be solvent because the structures are beneath the size that influences lucidity.…”

Section: Discussionmentioning

confidence: 99%

Solubility Enhancement of Drugs with Aid of Surfactants: Research Done Since Last Two Decades

Ramyasree¹,

Hindustan²,

Chinthaguinjala³

et al. 2020

Int J Pharma Bio Sci

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This review aims to explore the past work done on the solubility enhancement of drugs using surfactants. Surfactants plays an important part in many routes of interest in both essential and practical science. The most vital function of surfactant is the formation of micelle in solution, which has specific significance in medicine because of their ability to improve the solubility of poorly water-soluble drugs, which need high doses to extend therapeutic plasma levels after oral administration. Poor water solubility is the major issue met with the formulation development of new chemical objects. A drug taken by the patient should present in the solution form at the site of absorption. The use of surfactants to elevate the dissolution of poorly soluble drugs has been employed. Surfactants can reduce surface tension and improve the dissolution of lipophilic drugs in the aqueous medium. When the levels of surfactants surpass their critical micelle concentration it deceives the drugs within the micelles. The authors collected sufficient literature on work done on the solubility enhancement of drugs using surfactants and presented in this paper. The authors conclude that this quick reference will be helpful for researchers in finding the literature on solubility enhancement of drugs using surfactants on a single click.

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“…These aggregates can incorporate hydrophobic drug molecules in their cores resulting in the phenomenon of ad-solubilization or co-adsorption (Cherkaoui et al, 2000). Buckton et al, (1991) shown that the rate of drug release can be much increased by the presence of surfactants at the solid surfaces as a third component system. The increased wettability of the surface of the solid particles may also be an important parameter in drug release investigation.…”

Section: 2-in Vitro Dissolution Studies From Celecoxib Adsorbate Anmentioning

confidence: 99%

Improvement the Release and Avaialbility of Celecoxib Co-Adsorbate From Floating Capsules

Abu-Elyazid

2012

Al-Azhar Journal of Pharmaceutical Sciences

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Celecoxib is a selective COX-2 inhibitor non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. Celecoxib is practically inslouble in GIT pH. Consequently, it suffers from low and variable bioavailability following oral administration of solutions (64-88%) and capsules (20-40%) In the present study, gastroretentive controlled release single-unit floating capsules of Celecoxib were designed and evaluated. Various grades of low and high viscosity polymers of HPMC 4000 and 15.000 cps and NaCMC were used for formulation of Celecoxib capsules.For the purpose of enhancing the poor dissolution rate of Celecoxib, co-adsorption with Tween 80 onto surface of Florite® was investigated in this study. Thus, controlled release limited by drug solubility was percluded and delivery of active material was controlled by the formulation. In the present study conventional capsules containing Celecoxib using HPMC and NaCMC were developed and evaluated. Floating capsules containing Celecoxib, co-adsorption with Tween 80 onto surface of Florite and Aerosil 200 in different ratios were also formulated and investigated for the release of the drug from these capsules. The results obtained of this study showed that Celecoxib capsules containing HPMC 15000cps as a swelling matrix has a good floating behaviour and retarding effect on the drug release. Also, different concentrations of sodium bicarbonate confirmed and maintained the floating properties of the prepared formulations without affecting the drug release. From DSC and X-ray diffraction studies it was found that crystalline Celecoxib was converted into the amorphous form in the presence of Florite® at (1:5 w/w drug: carrier ratio) in the adsorbate and co-adsorbate with Tween 80. The loaded and ground mixtures of Celecoxib with either Florite® or Aerosil 200 increased the dissolution rate of the drug. Furthermore, co-adsorbate of the drug with Florite® and Tween 80 at these ratios of (1:5:3 and 1:5:5) gave the highest percentage released of Celecoxib (reached about 100% at 30 and 45 min., respectively).

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The influence of surfactants on drug release from acrylic matrices

Cited by 17 publications

References 3 publications

Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copolymer

Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copolymer

Solubility Enhancement of Drugs with Aid of Surfactants: Research Done Since Last Two Decades

Improvement the Release and Avaialbility of Celecoxib Co-Adsorbate From Floating Capsules

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