The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery

Natalini, Paola M.; Razuc, Mariela Fernanda; Sørli, Jorid B.; Bucalá, Verónica; Ramírez-Rigo, María Verónica

doi:10.1016/j.jddst.2019.101162

Cited by 5 publications

(4 citation statements)

References 49 publications

(52 reference statements)

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“…Overall, these results seem to suggest that Amk-DCA was well tolerated upon challenging the mice with two repeated administrations via the pulmonary route. This observation is important considering the variable toxicity of bile acids that remains a major concern, regardless of their reported potentiality in pulmonary drug delivery [ 38 , 39 , 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

Initial In Vivo Evaluation of a Novel Amikacin-Deoxycholate Hydrophobic Salt Delivers New Insights on Amikacin Partition in Blood and Tissues

et al. 2021

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In this study, an initial in vivo evaluation of a new amikacin-deoxycholate hydrophobic salt aimed at potentiating amikacin action against hard-to-treat lung infections was undertaken by quantifying, for the first time, amikacin in whole blood. Pharmacokinetic evaluation after intranasal administration in a murine model showed higher drug retention in the lungs compared to blood, with no significant differences between the salt and the free drug. Upon repeated administrations, the two treatments resulted in nonsignificant tissue damage and mild higher inflammation for the hydrophobic salt. Whole-blood analysis highlighted an unreported high partition of amikacin in blood components up to 48 h, while significant lung levels were measured up to 72 h. Such a new observation was considered responsible for the nearly overlapping pharmacokinetic profiles of the two treatments. To overcome such an issue, a dry powder in an inhalable form may be best suited. Moreover, if confirmed in humans, and considering the current once-a-day regimen for amikacin aerosols, important yet-to-be-explored clinical implications may be postulated for such amikacin persistence in the organism.

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Section: Resultsmentioning

confidence: 99%

Initial In Vivo Evaluation of a Novel Amikacin-Deoxycholate Hydrophobic Salt Delivers New Insights on Amikacin Partition in Blood and Tissues

et al. 2021

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“…Sodium deoxycholate was reported as part of biamphiphiles, ionic compounds with both cationic and anionic amphiphilic nature, which aggregate shape could be accurately controlled [ 87 ]; micellar catalyst for the synthesis of 1,2,3-triazole derivatives; their characteristics is superior in comparison with those of conventional surfactants CTAB and Triton-X-100 [ 88 ]. Sodium taurodeoxyholate was documented as a compound for regulation of solubility of steroid drug in surfactant micellar solutions and biorelevant media [ 89 ] and as a component of composition for albendazole delivery for the treatment of lung parasites [ 90 ].…”

Section: Self-assembly Of Amphiphilic Compoundsmentioning

confidence: 99%

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Kashapov

Gaynanova

Gabdrakhmanov

et al. 2020

IJMS

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This review focuses on synthetic and natural amphiphilic systems prepared from straight-chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale aggregates of different morphology and their application as drug carriers. Since numerous biological species (lipid membrane, bacterial cell wall, mucous membrane, corneal epithelium, biopolymers, e.g., proteins, nucleic acids) bear negatively charged fragments, much attention is paid to cationic carriers providing high affinity for encapsulated drugs to targeted cells. First part of the review is devoted to self-assembling and functional properties of surfactant systems, with special attention focusing on cationic amphiphiles, including those bearing natural or cleavable fragments. Further, lipid formulations, especially liposomes, are discussed in terms of their fabrication and application for intracellular drug delivery. This section highlights several features of these carriers, including noncovalent modification of lipid formulations by cationic surfactants, pH-responsive properties, endosomal escape, etc. Third part of the review deals with nanocarriers based on macrocyclic compounds, with such important characteristics as mucoadhesive properties emphasized. In this section, different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.

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“…Currently, bile acids are being used parenterally, orally as well as inhalationally for various cholestatic and other diseases. In the latter route, the bile salts have been found to affect the porosity of nanoformulations leading to aerodynamic properties which facilitate drug delivery into the lungs [ 8 , 9 ].…”

Section: Sometimes Complex Situations Seek Simple Solutionsmentioning

confidence: 99%

Can Natural Detergent Properties of Bile Acids Be Used Beneficially in Tackling Coronavirus disease-19?

2020

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The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery

Abstract: The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery,

Cited by 5 publications

References 49 publications

Initial In Vivo Evaluation of a Novel Amikacin-Deoxycholate Hydrophobic Salt Delivers New Insights on Amikacin Partition in Blood and Tissues

Initial In Vivo Evaluation of a Novel Amikacin-Deoxycholate Hydrophobic Salt Delivers New Insights on Amikacin Partition in Blood and Tissues

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Can Natural Detergent Properties of Bile Acids Be Used Beneficially in Tackling Coronavirus disease-19?

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