The influence of surface roughness on the adhesive interactions and phase behavior of suspensions of calcite nanoparticles

Olarte-Plata, Juan D.; Brekke-Svaland, Gøran; Bresme, Fernando

doi:10.1039/d0nr00834f

Cited by 9 publications

(8 citation statements)

References 42 publications

(64 reference statements)

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“…In addition, particles with smoother surfaces feature strong adhesive forces. 44 The nitrogen adsorption–desorption linear isotherms of untreated ground eggshell particles, PCC in the presence of PSS polyelectrolyte with low salt molar concentration and a silver loaded calcium carbonate are shown in Fig. 8C .…”

Section: Resultsmentioning

confidence: 99%

Tuning polymorphs of precipitated calcium carbonate from discarded eggshells: effects of polyelectrolyte and salt concentration

Azarian

Sutapun

2022

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Tuning polymorphs of precipitated calcium carbonate from discarded eggshells: effects of polyelectrolyte and salt concentration

Azarian

Sutapun

2022

RSC Adv.

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“…Simulations of NP-membrane interactions show that NP surface roughness greatly minimizes repulsive interactions, thereby promoting adhesion. [30,31] In the present work, hydrophilic and hydrophobic 100 nm quasi-spherical (AuNSPs) and star (AuNSTs) shape AuNPs were synthesized to explore the antibacterial mechanism of non-translocating AuNPs as a function of size, shape, and surface charge. [5,32] The surface charge and chemical properties of the NPs were determined by capping agents which play a crucial role in controlling the interactions between bacteria and the NPs (Figure 3).…”

Section: R Rn =mentioning

confidence: 99%

“…Simulations of NP–membrane interactions show that NP surface roughness greatly minimizes repulsive interactions, thereby promoting adhesion. [ 30,31 ]…”

Section: Figurementioning

confidence: 99%

Antibacterial Action of Nanoparticles by Lethal Stretching of Bacterial Cell Membranes

et al. 2020

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Nanoparticles (NPs) are heavily used in biomedical, industrial, and commercial applications due to the benefits associated with the specific physical and chemical properties of both the bulk and the nanoscale material. The antimicrobial activity of NPs is widely recognized, but the mechanisms of their underlying toxicity remain unclear despite repeated attempts to establish a structure-function relationship between their physicochemical properties and their interactions with biological systems. [1,2] NP uptake in mammalian cells is generally considered to be an active process, mediated by endocytosis. Indeed, transport across the cell membrane and intracellular accumulation dictates the nanoparticle fate and cytotoxicity. [3] The critical size for NPs non-disruptively (passively) crossing cellular membranes is below 10 nm, irrespective of surface functionalization, [4-7] Figure 1. For this reason, there is a slowly forming consensus that smaller NPs bear greater toxicity than larger ones. [8,9] Similarly, the antibacterial properties of small NPs have It is commonly accepted that nanoparticles (NPs) can kill bacteria; however, the mechanism of antimicrobial action remains obscure for large NPs that cannot translocate the bacterial cell wall. It is demonstrated that the increase in membrane tension caused by the adsorption of NPs is responsible for mechanical deformation, leading to cell rupture and death. A biophysical model of the NP-membrane interactions is presented which suggests that adsorbed NPs cause membrane stretching and squeezing. This general pheno menon is demonstrated experimentally using both model membranes and Pseudomonas aeruginosa and Staphylococcus aureus, representing Gram-positive and Gram-negative bacteria. Hydrophilic and hydrophobic quasi-spherical and star-shaped gold (Au)NPs are synthesized to explore the antibacterial mechanism of non-translocating AuNPs. Direct observation of nanoparticle-induced membrane tension and squeezing is demonstrated using a custom-designed microfluidic device, which relieves contraction of the model membrane surface area and eventual lipid bilayer collapse. Quasi-spherical nanoparticles exhibit a greater bactericidal action due to a higher interactive affinity, resulting in greater membrane stretching and rupturing, corroborating the theoretical model. Electron microscopy techniques are used to characterize the NP-bacterial-membrane interactions. This combination of experimental and theoretical results confirm the proposed mechanism of membrane-tension-induced (mechanical) killing of bacterial cells by non-translocating NPs.

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“…Indeed, computational studies have shown that NPs transition from an associated percolating gel to a dissociated fluid phase when surface roughness is incorporated. 36 To investigate the effects of roughness, we also obtained the MFEP of atomically corrugated "rough" nanocubes as introduced earlier. Fig.…”

Section: Effect Of Surface Roughnessmentioning

confidence: 99%

Assembly mechanism of surface-functionalized nanocubes

Lee

Arya

2022

Nanoscale

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The influence of surface roughness on the adhesive interactions and phase behavior of suspensions of calcite nanoparticles

Abstract: Nanoparticle roughness influences the adhesive interactions between calcite nanoparticles inhibiting the formation of gel phases.

Cited by 9 publications

References 42 publications

Tuning polymorphs of precipitated calcium carbonate from discarded eggshells: effects of polyelectrolyte and salt concentration

Tuning polymorphs of precipitated calcium carbonate from discarded eggshells: effects of polyelectrolyte and salt concentration

Antibacterial Action of Nanoparticles by Lethal Stretching of Bacterial Cell Membranes

Assembly mechanism of surface-functionalized nanocubes

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