The Influence of Subclinical Hyperthyroidism on Blood Pressure, Heart Rate Variability, and Prevalence of Arrhythmias

Kamiński, Grzegorz; Makowski, Karol; Michałkiewicz, Dariusz; Kowal, Jarosław; Ruchała, Marek; Szczepanek, Ewelina; Gielerak, Grzegorz

doi:10.1089/thy.2010.0333

Cited by 53 publications

(66 citation statements)

References 22 publications

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“…The high level of subclinical hyperthyroidism in this study shows that similar findings were elicited to those of studies suggesting that iodine supplementation increases predisposition to hyperthyroidism by causing thyroid tissue to acquire autonomy [5][6][7]. Increased predisposition to hyperthyroidism as a result of iodine supplementation also increases the prevalence of diseases associated with the thyroid, such as hypertension [18][19]. In addition, it has been suggested that iodine supplementation due to endemic hypothyroidism increases the incidence of hypothyroidism, rather than treating it, and close monitoring of iodine supplementation has been advised [2,8].…”

Section: Discussionsupporting

confidence: 85%

The evaluation of thyroid function tests in patients presenting to the family medicine clinics

Sezgin¹

2018

Ann Clin Anal Med

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Aim: Publications concerning the effects in society of recommendations regarding iodine supplementation over the last approximately 30 years are inconsistent. In addition to studies suggesting that iodine supplementation is insufficient, others report that it can lead to hyperthyroidism. We planned this study in order to investigate the results of iodine supplementation in our region through the retrospective screening of records of patients presenting to the family medicine clinics. Material and Method: This was a retrospective, cross-sectional study. Five hundred seventy-two patients undergoing TSH and free T3 and free T4 measurement were included. All numerical data were categorized and expressed as number and percentage and then subjected to chi square analysis.Results: Free T3 and free T4 values were within reference ranges at a level of almost 100%. However, only 85% of TSH values were within references ranges, and 12.9% were low. Discussion: The suppression of TSH values in this study shows an increased predisposition to subclinical hyperthyroidism. In the light of these findings, hyperthyroidism must be carefully monitored in addition to hypothyroidism in the approach to thyroid diseases.

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Section: Discussionsupporting

confidence: 85%

The evaluation of thyroid function tests in patients presenting to the family medicine clinics

Sezgin¹

2018

Ann Clin Anal Med

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“…Studies have shown that OH and SCH are closely related to a variety of metabolic disorders including obesity, hypertension, dyslipoproteinemia, insulin resistance/diabetes mellitus, and cardiovascular diseases. [15,16,23,24] Many metabolic regulators and adipokines/hepatokines including leptin, adiponectin, resistin, and FGF21 were found to be altered with thyroid dysfunction. [25] …”

Section: Discussionmentioning

confidence: 99%

Serum fibroblast growth factor 19 is decreased in patients with overt hypothyroidism and subclinical hypothyroidism

Lai

Wang²,

Xia³

et al. 2016

Medicine

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As a newly emerging metabolic regulator, accumulating evidence suggests that the circulating fibroblast growth factor 19 (FGF19) level correlated with lipid and glucose metabolism. Several independent groups have found that FGF19 was highly likely associated with multiple metabolic disorders. Thyroid dysfunction is believed to be associated with metabolism diseases. However, to date, few studies have investigated the role of FGF19 in patients with thyroid dysfunctions. For this purpose, a cross-sectional study was done to estimate the role of FGF19 in patients with different thyroid functions. Compared with the healthy control, the present study revealed that serum FGF19 levels were significantly decreased in overt hypothyroidism patients (78.7 [52.7–121.2] vs 292.4 [210.2–426.5] pg/mL, P <0.001). FGF19 concentration was also lower in the subclinical hypothyroidism group than it was in the healthy control group (95.8 [71.7–126.3] vs 292.4 [210.2–426.5] pg/mL, P <0.001). However, there was no significant difference in FGF19 level between the isolated thyroid autoantibody positive group and the healthy control group (252.0 [205.9–353.5] vs 292.4 [210.2–426.5] pg/mL, P >0.05). Also, serum thyroid stimulating hormone (TSH) was an independent predictor of FGF19. In conclusion, thyroid insufficiency but not thyroid autoimmunity may have impacted serum FGF19 concentrations. As the role of FGF19 is becoming more and more important in the pathogenesis of many metabolic diseases, we proposed that the thyroid hormone level should be taken into account when the serum concentration is explained. Further studies are needed to elucidate the role of FGF19 in the development of hypothyroidism.

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“…A recent study showed that subclinical hyperthyroidism affected nocturnal blood pressure levels. Normotensive patients with subclinical hyperthyroidism showed higher systolic (109.3 7.1 vs 107.1 .7.7 mmHg, P 0.035) and diastolic blood pressure levels at night (66.4 6.6 vs 64.8 6.6 mmHg, P 0.047) 34) . Therefore, both hyperthyroid and hypothyroid states increase blood pressure levels, indicating that euthyroid state is important for the maintenance of appropriate blood pressure levels.…”

Section: Lipid Profilementioning

confidence: 94%

Thyroid Hormone and Vascular Remodeling

Ichiki

2016

JAT

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Both hyperthyroidism and hypothyroidism affect the cardiovascular system. Hypothyroidism is known to be associated with enhanced atherosclerosis and ischemic heart diseases. The accelerated atherosclerosis in the hypothyroid state has been traditionally ascribed to atherogenic lipid profile, diastolic hypertension, and impaired endothelial function. However, recent studies indicate that thyroid hormone has direct anti-atherosclerotic effects, such as production of nitric oxide and suppression of smooth muscle cell proliferation. These data suggest that thyroid hormone inhibits atherogenesis through direct effects on the vasculature as well as modification of risk factors for atherosclerosis. This review summarizes the basic and clinical studies on the role of thyroid hormone in vascular remodeling. The possible application of thyroid hormone mimetics to the therapy of hypercholesterolemia and atherosclerosis is also discussed.

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The Influence of Subclinical Hyperthyroidism on Blood Pressure, Heart Rate Variability, and Prevalence of Arrhythmias

Cited by 53 publications

References 22 publications

The evaluation of thyroid function tests in patients presenting to the family medicine clinics

The evaluation of thyroid function tests in patients presenting to the family medicine clinics

Serum fibroblast growth factor 19 is decreased in patients with overt hypothyroidism and subclinical hypothyroidism

Thyroid Hormone and Vascular Remodeling

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