The influence of stress and state anxiety on the outcome of IVF‐treatment: Psychological and endocrinological assessment of Swedish women entering IVF‐treatment

Csemiczky, G.; Landgren, Britt-Marie; Collins, Aila

doi:10.1034/j.1600-0412.2000.079002113.x

Cited by 171 publications

(164 citation statements)

References 11 publications

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“…21,35 Not surprisingly, infertility is associated with increased levels of stress, anxiety and depression, 10,23 suggesting that any effects attributed to estradiol changes in fact may be related to reduced coping/cooperation or increased sensitivity due to the different biological effects of long-term stress. Still, Verhaak et al, 44 reviewing 25 years 13 of research on emotional reactions in women undergoing IVF treatment, found that subjects in the treatment phase, i.e.…”

Section: Discussionmentioning

confidence: 99%

Influence of Estrogen Levels on Thermal Perception, Pain Thresholds, and Pain Tolerance: Studies on Women Undergoing in Vitro Fertilization

Stening

Berg

Hammar

et al. 2012

The Journal of Pain

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We examined the relationship between estrogen and pain in women undergoing in vitro fertilization (IVF). Quantitative sensory tests (QST) were performed twice during the IVF-regimen: once during hormonal down-regulation and once during hormonal upregulation. A group of healthy men and a group of women using monophasic contraceptives were also examined, to control for session-to-session effects. Among the women undergoing IVF, serum 17β-estradiol levels differed strongly between treatments as expected, and increased from 65.7 (SD = 26) pmol/l during the downregulation phase, to 5188 (SD = 2524) pmol/l during the up-regulation phase.Significant outcomes in the QST were only seen for temperature perception thresholds (1.7°C vs. 2.2°C; P = 0.003) and cold pain threshold (11.5°C vs. 14.5°C; P = 0.04). A similar change in cold pain threshold was also seen in the two control groups, however, and statistical analysis suggested that this change was due to a session-to-session effect rather than being the result of hormonal modulation. Heat pain thresholds, heat tolerance, pressure pain thresholds, and the cold pressor test showed no significant differences between sessions. These data demonstrate that pain perception and pain thresholds in healthy women show little, if any, changes even with major variations in serum estradiol levels. PerspectiveThis study shows that pain perception and tolerance in women undergoing in vitro fertilization do not vary, despite the dramatic changes in 17β-estradiol levels induced by the treatment regimen. The result thus suggests that in humans, contrary to experimental animals, changes in estrogen levels have little influence on pain sensitivity.

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Section: Discussionmentioning

confidence: 99%

Influence of Estrogen Levels on Thermal Perception, Pain Thresholds, and Pain Tolerance: Studies on Women Undergoing in Vitro Fertilization

Stening

Berg

Hammar

et al. 2012

The Journal of Pain

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show abstract

“…High levels of psychological stress, anxiety, insomnia, depression, and sexual function changes have been reported during in vitro fertilization-embryo transfer (IVF-ET) [1][2][3][4][5][6]. These are related to a number of stresses that are the results of both the diagnosis and treatment of infertility [7].…”

mentioning

confidence: 99%

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Eryılmaz

Devran

Sarıkaya

et al. 2011

J Assist Reprod Genet

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Purpose We aimed to analyse the in vitro fertilizationembryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin. Methods A total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n=30) had underwent the IVF-ET with melatonin administration and the control group (group B, n=30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups. Results Sleeping status change was not significant (p>0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p=0.0001; p=0.0001; p<0.05 respectively. Conclusion IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.

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“…Many women consider infertility to be the most stressful experience in their lives [3], and stress may affect IVF outcomes [3][4][5][6]. In our experience, patients feel that they may experience less stress if their own physician performs the embryo transfer, and wonder if pregnancy would be more likely to occur.…”

Section: Discussionmentioning

confidence: 84%

Should a patient's own IVF physician perform the embryo transfer?

Estes¹,

Missmer²,

Ginsburg³

2006

J Assist Reprod Genet

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Purpose: To compare pregnancy rates of embryo transfers performed by a patient's own IVF physician to pregnancy rates of embryo transfers performed by other physicians on the IVF team.Methods: Retrospective cohort study; University hospital.Results: A total of 3029 embryo transfers were included. 434 patients (14%) had an embryo transfer by their own IVF physician. There was no difference in pregnancy rates comparing patients who had embryos transferred by a different physician than their own IVF physician when all cycle attempts were analyzed [Odds ratio (OR) 1

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The influence of stress and state anxiety on the outcome of IVF‐treatment: Psychological and endocrinological assessment of Swedish women entering IVF‐treatment

Cited by 171 publications

References 11 publications

Influence of Estrogen Levels on Thermal Perception, Pain Thresholds, and Pain Tolerance: Studies on Women Undergoing in Vitro Fertilization

Influence of Estrogen Levels on Thermal Perception, Pain Thresholds, and Pain Tolerance: Studies on Women Undergoing in Vitro Fertilization

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems

Should a patient's own IVF physician perform the embryo transfer?

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