The influence of SRPK1 on glioma apoptosis, metastasis, and angiogenesis through the PI3K/Akt signaling pathway under normoxia

Chang, Yingwei; Wu, Qianqian; Tian, Ting; Li, Li; Guo, Xijing; Feng, Zhuoying; Zhou, Junchen; Zhang, Luping; Zhou, Shuai; Feng, Guoying; Han, Fengchan; Yang, Jun; Huang, Fei

doi:10.1007/s13277-015-3289-2

Cited by 36 publications

(31 citation statements)

References 40 publications

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“…It has been reported that the HP gene is relevant to IA, but few previous studies have reported the correlation between SRPK1 and IA. However, in some other tumor diseases, it has been reported that SRPK1 affects progression of diseases through the PI3 K/AKT signaling pathway . In addition, it was also reported that the AKT signaling pathway was involved in the progression of aneurysms, but have not yet been demonstrated in IA.…”

Section: Resultsmentioning

confidence: 99%

“…However, in some other tumor diseases, it has been reported that SRPK1 affects progression of diseases through the PI3 K/AKT signaling pathway. [24][25][26] In addition, it was also reported that the AKT signaling pathway was involved in the progression of aneurysms, 27,28 but have not yet been demonstrated in IA. In summary, our results suggested that SRPK1 may affect the progression of IA by regulating the PI3 K/AKT signaling pathway.…”

Section: Srpk1 and The Pi3 K/akt Signaling Pathway Are Related To Tmentioning

confidence: 99%

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SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms

Wang

2018

CNS Neurosci Ther

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Section: Resultsmentioning

confidence: 99%

Section: Srpk1 and The Pi3 K/akt Signaling Pathway Are Related To Tmentioning

confidence: 99%

SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms

Wang

2018

CNS Neurosci Ther

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“…4,30,31) Furthermore, previous studies have demonstrated that BDNF promotes cell proliferation and migration through the PI3K/Akt pathway. 32) Moreover, insulin receptor substrate-4 (IRS-4) enhances cell migration via the PI3K/Akt pathway.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg1 Promotes the Migration of Olfactory Ensheathing Cells <i>via</i> the PI3K/Akt Pathway to Repair Rat Spinal Cord Injury

Tang

Guo

et al. 2017

Biological & Pharmaceutical Bulletin

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The aim of this study was to determine the effects of ginsenoside Rg1 on the migration of olfactory ensheathing cells (OECs) in vitro, and its influence on the therapeutic efficacy of OECs transplanted in vivo for the treatment of spinal cord injury (SCI). Primary cultured and purified OECs (prepared from rats) were treated with ginsenoside Rg1. The wound healing test indicated that ginsenoside Rg1 promoted the migration of OECs. Real-time RT-PCR demonstrated that ginsenoside Rg1 upregulated the expression of migration-related factors of OECs, including matrix metalloproteinases-2 (MMP-2), MMP-9, and neural cell adhesion molecule 1 (NCAM1). Moreover, Western blot analysis indicated that ginsenoside Rg1 significantly promoted the migration of OECs via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. An SCI rat model was induced in vivo using a revised Allen's method. The Basso, Beattie, and Bresnahan (BBB) scores and histological analysis demonstrated that OECs, which were treated with ginsenoside Rg1, exhibited significant improvement in SCI compared with both the control group and the OEC group. Thus, ginsenoside Rg1 may represent a novel treatment target for SCI.

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“…The plexin-B1/SRPK1 pathway regulates cell motility, apoptosis, and angiogenesis [69] ↑SRPK1 was found in glioma cell lines ↓SRPK1 suppressed cell viability and response to chemotherapy in vitro [52] ↑SRPK1 was found in glioma cell lines ↓SRPK1 suppressed apoptosis in vivo and in vitro, also migration and invasion in vivo SRPK1 interacts with the PI3K/Akt pathway and modulates the expression of MMP-2 and MMP-9 [70]…”

Section: ↓Srpk1 Suppressed Migration and Invasion In Vitromentioning

confidence: 99%

Serine-Arginine Protein Kinase 1 (SRPK1) as a Prognostic Factor and Potential Therapeutic Target in Cancer: Current Evidence and Future Perspectives

Nikas

Themistocleous

Paschou

et al. 2019

Cells

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Cancer, a heterogeneous disease composed of tumor cells and microenvironment, is driven by deregulated processes such as increased proliferation, invasion, metastasis, angiogenesis, and evasion of apoptosis. Alternative splicing, a mechanism led by splicing factors, is implicated in carcinogenesis by affecting any of the processes above. Accumulating evidence suggests that serine-arginine protein kinase 1 (SRPK1), an enzyme that phosphorylates splicing factors rich in serine/arginine domains, has a prognostic and potential predictive role in various cancers. Its upregulation is correlated with higher tumor staging, grading, and shorter survival. SRPK1 is also highly expressed in the premalignant changes of some cancers, showing a potential role in the early steps of carcinogenesis. Of interest, its downregulation in preclinical models has mostly been tumor-suppressive and affected diverse processes heterogeneously, depending on the oncogenic context. In addition, targeting SRPK1 has enhanced sensitivity to platinum-based chemotherapy in some cancers. Lastly, its aberrant function has been noted not only in cancer cells but also in the endothelial cells of the microenvironment. Although the aforementioned evidence seems promising, more studies are needed to reinforce the use of SRPK1 inhibitors in clinical trials. major area of research in the field of intratumor heterogeneity, while their presence is associated with cancer recurrence, metastasis, and resistance to chemotherapy [7].Cancer prognosis depends on multiple factors that affect survival. Tumor staging, traditionally performed with the TNM system, is the most important prognostic factor. It refers to the size of the tumor (T), also the extent of its spread to the regional lymph nodes (N) or distant metastatic sites (M) [8,9]. Grading refers to the histologic picture of the tumor, more specifically, how closely it looks compared to the normal tissue it derives from (differentiation) [10,11]. Both the presence of distant metastases (e.g., in lungs, brain, liver, bones) and poor differentiation are associated with a dismal prognosis [9,11]. The molecular subtype of specific cancers is also critical for cancer survival. For instance, breast cancer has diverse intrinsic subtypes-luminal A and B, human epidermal growth factor receptor 2-enriched (HER2-enriched), and basal-like-that directly impact prognosis [12][13][14]. Luminal breast cancers are most commonly hormone-positive, overexpressing estrogen receptors (ER), and are associated with a better prognosis than HER2-enriched or basal-like breast cancers (BLBCs) [12][13][14][15]. BLBCs, which most commonly present with a triple-negative phenotype, have been linked with the worst prognosis and highest metastatic potential of all breast cancer molecular subtypes [13,16,17].Alternative splicing is the process that removes introns and adds exons in various combinations resulting in multiple mRNA products hence protein transcripts. As a result, it maintains the protein diversity and cellular homeostasis [18]. The...

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The influence of SRPK1 on glioma apoptosis, metastasis, and angiogenesis through the PI3K/Akt signaling pathway under normoxia

Cited by 36 publications

References 40 publications

SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms

SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms

Ginsenoside Rg1 Promotes the Migration of Olfactory Ensheathing Cells <i>via</i> the PI3K/Akt Pathway to Repair Rat Spinal Cord Injury

Serine-Arginine Protein Kinase 1 (SRPK1) as a Prognostic Factor and Potential Therapeutic Target in Cancer: Current Evidence and Future Perspectives

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