The Influence of Some Antipsychotics on Erythrocyte Magnesium and Plasma Magnesium, Calcium, Copper and Zinc in Patients with Paranoid Schizophrenia

Nechifor, M; Văideanu, C.; Palamaru, I.; Borza, Claudia; Mîndreci, I

doi:10.1080/07315724.2004.10719401

Cited by 48 publications

(29 citation statements)

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“…15 In a study conducted on 56 patients suffering from schizophrenia, erythrocyte and plasma Zn levels were found to be reduced. 16 In another study, no significant difference was seen in Zn levels between patients of schizophrenia and control. 17 It was concluded that Zn deficiency during gestation might be a factor in causing brain anomalies and schizophrenia, but after birth these changes may not be associated with the patient's nutritional status.…”

Section: Introductionmentioning

confidence: 96%

Effect of zinc in animal models of anxiety, depression and psychosis

et al. 2012

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The role of zinc (Zn) in anxiety, depression and psychosis was studied in rodents. Zn was administered at doses of 15 and 20 mg/kg intraperitoneally for 7 days. Both doses of Zn reduced the immobility time and increased the swimming time in the modified forced swim test. In the elevated plus maze test, increases in the number of open arm entries and time spent in the open arms were observed with both doses of Zn. In the amphetamine (1 and 2 mg/kg subcutaneously) induced locomotor activity test both doses of Zn produced reduction in the total movement time, mean velocity and stereotypic movements. Extrapyramidal symptoms such as catalepsy in animals are usually observed with conventional antipsychotic agents; but in the present study, Zn at doses of 15 and 20 mg/kg did not produce any cataleptic state in mice. The results of the present study demonstrated the anxiolytic, antidepressant and antipsychotic-like effects of Zn metal ion, which may be due to its N-methyl d-aspartate receptor antagonistic activity. Concurrent administration of a lower dose of Zn with standard existing anxiolytic and antidepressant drugs in this study showed potentiating effect, suggesting that Zn could exert beneficial role when prescribed as add-on medicine in the psychiatric illnesses. The results obtained in this study are preliminary, as further research is required to confirm the exact role of Zn metal in the investigated central nervous system disorders.

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Section: Introductionmentioning

confidence: 96%

Effect of zinc in animal models of anxiety, depression and psychosis

et al. 2012

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“…Some authors have reported a higher or decreased Mg concentration in the CSF of schizophrenic patients, a decreased plasma Mg or unchanged plasma Mg concentration before neuroleptic therapy and a decreased level after neuroleptic therapy in schizophrenic patients. A lower Mg level in the erythrocytes of schizophrenic patients has been obtained. Erythrocyte Mg concentration is higher after haloperidol and risperidone treatment than in the erythrocytes of schizophrenic patients pre‐drug treatment and increased Mg erythrocytes concentration is important for antipsychotic action of these neuroleptics .…”

Section: Discussionmentioning

confidence: 87%

“…This is because of inhibition of NMDA receptors on GABA neuron (main inhibitory pathway in the CNS) and there are no inhibitions of the major excitatory pathway that innervates the cerebrocortical and limbic brain region . To date, only a few studies have been performed on Mg and Ca concentration in patients with schizophrenia and consistent results have not been obtained . The majority of investigations determined the concentration of Mg and Ca in serum or plasma, which does not reflect the true state of the supply of the organism with Mg, as only 1% of the Mg is in blood plasma.…”

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confidence: 99%

Platelet and serum calcium and magnesium concentration in suicidal and non‐suicidal schizophrenic patients

Ruljančić

Mihanović

Čepelak

et al. 2013

Psychiatry Clin Neurosci

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Aim:The main processes modulated by Ca and involved in the cause of schizophrenia are alteration in the dopamine and glutamate neurotransmitter system. Intracellular effects of Mg-ions are opposite to Ca-ions in competition at K-ion channels, in Na/ K-ATP-ase activity, cAMP/cGMP concentration and Ca-ion currents in pre-and postsynaptic membranes. We conducted this research due to the incongruent results on Ca and Mg concentration that have been published until now and to determine platelet Mg concentration in suicidal and non-suicidal schizophrenic patients.Methods: A group of schizophrenic patients consisted of 23 patients with attempted suicide (S-SCH) and 48 patients without suicidal behavior (K-SCH) diagnosed according to ICD-10 diagnosis (F20.0) with or without intentional self-harm (X60-X84). The control group (K) included 99 healthy voluntary blood donors. The Mg and Ca concentration in platelets and serum was determined by atomic absorption spectrophotometry on the AAnalyst 200.Results: Using one-way ANOVA test and manifold application of the Student-Newman-Keuls post-hoc test we established that there were higher concentrations of platelet Mg (mmol/109 platelets) (P = 0.009, F = 4.89) and lower concentrations of serum Ca (mmol/L) (P < 0.001, F = 19.18) in the S-SCH group of patients and higher concentrations of platelet Ca/Mg ratio in the K-SCH group of patients (P = 0.006, F = 5.37). Conclusion:A higher Ca/Mg ratio in the platelets of non-suicidal patients confirms indirect higher Ca concentration. Higher Mg concentration in the platelets of suicidal patients, considered a Ca antagonist, may represent a compensatory attempt to restrain Ca activity.

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“…Huang et al (2004) injected magnesium sulfate to pregnant women with high blood pressure and calculated serum calcium 4 hrs later. They observed that serum calcium is decreased significantly 12 . observed that treatment of preeclamptic women leads to 25% decrease in total calcium and 12% decrease in ionic calcium 13 .…”

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confidence: 99%

A Comparative Study of Total Albumin and Calcium Level between Preeclamptic Women Undergoing Magnesium Sulfate Therapy and with Normal Pregnancies

Emami¹,

Najib²,

Poordast³

et al. 2015

Biosci., Biotech. Res. Asia

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Magnesium sulfate is used for seizure therapy and profilaxy in women with eclampsia and preeclampsia worldwide. Magnesium has effect on calcium modulation and also there are antithesis reports about alternation between magnesium sulfate therapy and decreased serum calcium level. Decreased in serum calcium level may cause some complications. The present study determines whether maternal serum level of calcium and albumin in patients with preeclampsia are lower than matched control subjects. Thirty patients with preeclampsia who were candidate for received magnesium sulfate therapy compared with 30 normal pregnant women as a control group. Serum calcium and albumin concentration were determined in 3 ml of venous blood sample that was taken before magnesium sulfate therapy, during and 24 hrs after discontinuation of therapy in preeclamptic women and also before and 8 hrs after delivery in normal pregnant women. Findings show no significance difference of maternal and gestational ages between the two groups. The change in mean concentration of albumin, total calcium level, and corrected serum calcium level was observed just significantly at the albumin level 24 hrs after the termination of therapy in preeclamptic group (3 mg/dl, 2.7 mg/dl) P=0.03. There is no any correlation between others items in two groups. In both two groups serum calcium level is more before delivery than after. In the preeclamptic group (9.1 mg/dl, 9 mg/dl) P=0.00 and in normotensive group (9.3 mg/dl, 9 mg/dl) P=0.00. According to this small group study magnesium sulfate therapy in preeclamptic women doesn't redounded to change in serum calcium level, but may lead to increased albumin level after delivery in control subject and also after discontinuation of the therapy in patients groups respectively. Keywords: Preeclampsia, Calcium, Albumin, Magnesium sulfate Preeclampsia has a high prevalence among pregnant women and it can lead to serious complications for them or even death 1, 2 . Magnesium sulfate is a common cure for prevention the eclampsia in these patients 3 . Ionic calcium is antagonized by magnesium ions 4,5 . Therefore, it seems that magnesium sulfate can decrease serum calcium and its adverse effects in preeclamptic patients. Decreased calcium serum is associated with some different effects such as convulsion, muscle spasm especially in the larynx, psychological problems, change in vital signs, and cardiac arrest; so that, it can potentially threaten life 6 . There are also some controversial reports on low calcium contents in preeclamptic patients [7][8][9][10] . In case of low calcium contents, magnesium sulfate can intensify the condition and cause serious complications 6 . Halhali et al. (2001) showed that preeclamptic patients have a low level of 2104 ASKARY et al., Biosci., Biotech. Res. Asia, Vol. 12(3), 2103-2110 (2015) parathormone and injection of magnesium sulfate can increase Calcitonin gene related peptide in them which leads to hypocalcemia 11 . Huang et al. (2004) injected magnesium sulfate to pregnant women...

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The Influence of Some Antipsychotics on Erythrocyte Magnesium and Plasma Magnesium, Calcium, Copper and Zinc in Patients with Paranoid Schizophrenia

Abstract: We consider plasma Cu(2+)/erythrocyte Mg(2+) and plasma Cu(2+)/Zn(2+) ratio two important biological markers of the acute paranoid schizophrenia.

Cited by 48 publications

References 9 publications

Effect of zinc in animal models of anxiety, depression and psychosis

Effect of zinc in animal models of anxiety, depression and psychosis

Platelet and serum calcium and magnesium concentration in suicidal and non‐suicidal schizophrenic patients

A Comparative Study of Total Albumin and Calcium Level between Preeclamptic Women Undergoing Magnesium Sulfate Therapy and with Normal Pregnancies

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