The Influence of Solvents and Colloidal Particles on the Efficiency of Molecular Antioxidants

Abstract

The radical scavenging activity of three molecular antioxidants (trolox, rutin and ellagic acid) was investigated in different solvents with and without added polymer-based colloidal particles (SL-IP-2). Rutin and ellagic acid showed poor solubility in water, preventing the accurate measurement of the effective antioxidant concentration values, which were determined in ethanol/water (EtOH/H2O) mixtures. The presence of trolox and rutin changed neither the surface charge properties nor the size of SL-IP-2 in these solvents, while significant adsorption on SL-IP-2 was observed for ellagic acid leading to overcharging and rapid particle aggregation at appropriately high antioxidant concentrations in EtOH/H2O. The differences in the radical scavenging capacity of trolox and ellagic acid that was observed in homogeneous solutions using water or EtOH/H2O as solvents vanished in the presence of the particles. Rutin lost its activity after addition of SL-IP-2 due to the larger molecular size and lower exposure of the functional groups to the substrate upon interaction with the particles. The obtained results shed light on the importance of the type of solvent and particle–antioxidant interfacial effects on the radical decomposition ability of molecular antioxidants, which is of crucial importance in industrial processes involving heterogeneous systems.

Enrichment of Water Bodies with Phenolic Compounds Released from Betula and Pinus Pollen in Surface Water

“…The presence of water-suspended particles and surface water matrices can likely affect the antioxidant activity of compounds. Particles can serve as surfaces for radical reactions and alter the accessibility of radicals to antioxidants [ 44 ]. The chemical structure of each compound determines its specific mode of action in neutralizing ROS [ 43 ].…”

Promising Bioactivity of Vitamin B1-Au Nanocluster: Structure, Enhanced Antioxidant Behavior, and Serum Protein Interaction

“…can be formed in living organisms, which can cause dysfunction and damage the tissues by facilitating cell death [ 15 , 16 ]. Apart from the generally used antioxidant lipid-based vesicles [ 17 , 18 ], niosomes [ 19 ], gels [ 20 ], and composite materials [ 21 ], ultra-small NCs are potential devices to prevent these issues because their composition is easily tuned by the selection of the appropriate metal and surface ligand to precisely design smart biomimetic materials [ 22 ]. Based on the above-mentioned utilization of few-atomic NCs with few atomic layers, antioxidant and enzyme-like applications should be a priority in future research.…”